{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:31:25Z","timestamp":1770982285513,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>During last decades, Magnetic Resonance (MR)\u2014compatible sensors based on different techniques have been developed due to growing demand for application in medicine. There are several technological solutions to design MR-compatible sensors, among them, the one based on optical fibers presents several attractive features. The high elasticity and small size allow designing miniaturized fiber optic sensors (FOS) with metrological characteristics (e.g., accuracy, sensitivity, zero drift, and frequency response) adequate for most common medical applications; the immunity from electromagnetic interference and the absence of electrical connection to the patient make FOS suitable to be used in high electromagnetic field and intrinsically safer than conventional technologies. These two features further heightened the potential role of FOS in medicine making them especially attractive for application in MRI. This paper provides an overview of MR-compatible FOS, focusing on the sensors employed for measuring physical parameters in medicine (i.e., temperature, force, torque, strain, and position). The working principles of the most promising FOS are reviewed in terms of their relevant advantages and disadvantages, together with their applications in medicine.<\/jats:p>","DOI":"10.3390\/s131014105","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T12:05:51Z","timestamp":1382097951000},"page":"14105-14120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":199,"title":["Optical Fiber-Based MR-Compatible Sensors for Medical Applications: An Overview"],"prefix":"10.3390","volume":"13","author":[{"given":"Fabrizio","family":"Taffoni","sequence":"first","affiliation":[{"name":"Unit of Biomedical Robotics and Biomicrosystems, Center for Integrated Research, Universit\u00e0 Campus Bio-Medico di Roma, Via \u00c1lvaro del Portillo, 21, Rome 00128, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0240-1265","authenticated-orcid":false,"given":"Domenico","family":"Formica","sequence":"additional","affiliation":[{"name":"Unit of Biomedical Robotics and Biomicrosystems, Center for Integrated Research, Universit\u00e0 Campus Bio-Medico di Roma, Via \u00c1lvaro del Portillo, 21, Rome 00128, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Saccomandi","sequence":"additional","affiliation":[{"name":"Unit of Measurements and Biomedical Instrumentation, Center for Integrated Research, Universit\u00e0 Campus Bio-Medico di Roma, Via \u00c1lvaro del Portillo, 21, Rome 00128, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pino","sequence":"additional","affiliation":[{"name":"Unit of Biomedical Robotics and Biomicrosystems, Center for Integrated Research, Universit\u00e0 Campus Bio-Medico di Roma, Via \u00c1lvaro del Portillo, 21, Rome 00128, Italy"},{"name":"Institute of Neurology, Campus Bio-Medico University, and Fondazione Alberto Sordi-Research Institute for Ageing, Center for Integrated Research, Universit\u00e0 Campus Bio-Medico di Roma, Via \u00c1lvaro del Portillo, 200, Rome 00128, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-1265","authenticated-orcid":false,"given":"Emiliano","family":"Schena","sequence":"additional","affiliation":[{"name":"Unit of Measurements and Biomedical Instrumentation, Center for Integrated Research, Universit\u00e0 Campus Bio-Medico di Roma, Via \u00c1lvaro del Portillo, 21, Rome 00128, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1126\/science.6422554","article-title":"1984 Fiber-optic sensors for biomedical applications","volume":"13","author":"Peterson","year":"1984","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chapman & Hall, Grattan, K.T.V., and Meggitt, B.T. (1998). Optical Fiber Sensor Technology, Springer.","DOI":"10.1007\/978-1-4615-5787-6"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nphoton.2008.19","article-title":"Medical applications: Saving lives","volume":"2","author":"Pinet","year":"2008","journal-title":"Nat. Photonics."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Silvestri, S., and Schena, E. (2011). Optical-fiber measurement systems for medical applications. Optoelectron. Devices Appl., 205\u2013224.","DOI":"10.5772\/18845"},{"key":"ref_5","unstructured":"Udd, E., and Spillman, WB. (1991). Fiber Optic Sensors, John Wiley & Sons, Inc."},{"key":"ref_6","unstructured":"Moscato, M., Schena, E., Saccomandi, P., Francomano, M., Accoto, D., Guglielmelli, E., and Silvestri, S. (September, January 28). A Micromachined Intensity-Modulated Fiber Optic Sensor for Strain Measurements: Working Principle and Static Calibration. San Diego, CA, USA."},{"key":"ref_7","unstructured":"Saccomandi, P., Schena, E., Di Matteo, F. M., Pandolfi, M., Martino, M., Rea, R., and Silvestri, S. (September, January 30). Laser Interstitial Thermotherapy for Pancreatic Tumor Ablation: Theoretical Model and Experimental Validation. Boston, MA, USA."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1109\/TMECH.2006.871897","article-title":"MRI\/fMRI-Compatible robotic system with force feedback for interaction with human motion","volume":"11","author":"Gassert","year":"2006","journal-title":"IEEE\/ASME Trans. Mech."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Dziuda, L., Skibniewski, F.W., Krej, M., and Baran, P.M. (2013). Fiber Bragg grating-based sensor for monitoring respiration and heart activity during magnetic resonance imaging examinations. J. Biomed. Opt., 18.","DOI":"10.1117\/1.JBO.18.5.057006"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1109\/JSEN.2010.2043732","article-title":"MRI-compatible fiber-optic force sensors for catheterization procedures","volume":"10","author":"Polygerinos","year":"2010","journal-title":"IEEE Sens. J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chinzei, K., Bikinis, R., and Joules, F.A. (1999, January 10\u201322). MR Compatibility of Mechatronic Devices: Design Criteria. Cambridge, UK.","DOI":"10.1007\/10704282_111"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1063\/1.89881","article-title":"Photosensitivity in optical fiber waveguides: Application to reflection filter fabrication","volume":"32","author":"Hill","year":"1978","journal-title":"Appl. Phys. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1364\/OL.14.000823","article-title":"Formation of Bragg gratings in optical fibers by a transverse holographic method","volume":"14","author":"Meltz","year":"1989","journal-title":"Opt. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1109\/50.618320","article-title":"Fiber Bragg grating technology fundamentals and overview","volume":"15","author":"Hill","year":"1997","journal-title":"J. Light. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1006\/ofte.1996.0036","article-title":"A review of recent developments in fiber optic sensor technology","volume":"2","author":"Kersey","year":"1996","journal-title":"Opt. Fiber Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.sna.2011.02.045","article-title":"Fiber grating sensors in medicine: Current and emerging applications","volume":"167","author":"Mishra","year":"2011","journal-title":"Sens. Actuators A Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1049\/ip-opt:19941419","article-title":"Thermally-compensated bending gauge using surface mounted fiber gratings","volume":"9","author":"Xu","year":"1994","journal-title":"Int. J. Optoelectron."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1117\/1.429860","article-title":"Optical in-fiber Bragg grating sensor systems for medical applications","volume":"3","author":"Rao","year":"1998","journal-title":"J. Biomed. Opt."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1096-9101(1998)23:2<94::AID-LSM7>3.0.CO;2-Q","article-title":"In situ temperature measurements with thermocouple probes during laser interstitial thermotherapy (LITT): Quantification and correction of a measurement artifact","volume":"23","author":"Manns","year":"1998","journal-title":"Lasers Surg. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1117\/1.429967","article-title":"First in vivo trials of a fiber Bragg grating based temperature profiling system","volume":"5","author":"Webb","year":"2000","journal-title":"J. Biomed. Opt."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1109\/TBME.2012.2210895","article-title":"Theoretical analysis and experimental evaluation of laser-induced interstitial thermotherapy in ex vivo porcine pancreas","volume":"59","author":"Saccomandi","year":"2012","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Saccomandi, P., Schena, E., Giurazza, F., del Vescovo, R., Caponero, M.A., Mortato, L., Panzera, F., Cazzato, R.L., Grasso, F.R., and di Matteo, F.M. (2013). Temperature monitoring and lesion volume estimation during double-applicator laser-induced thermotherapy in ex vivo swine pancreas: A preliminary study. Laser. Med. Sci., 1\u20138.","DOI":"10.1007\/s10103-013-1360-z"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Schena, E., Saccomandi, P., Giurazza, F., Caponero, M.A., Mortato, L., di Matteo, F.M., Panzera, F., del Vescovo, R., Zobel, B.B., and Silvestri, S. (2013). Experimental assessment of CT-based thermometry during laser ablation of porcine pancreas. Phys. Med. Biol., in press.","DOI":"10.1088\/0031-9155\/58\/16\/5705"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1464-410X.2007.06983.x","article-title":"Cryotherapy for the prostate: An in vitro and clinical study of two new developments; Advanced cryoneedles and a temperature monitoring system","volume":"100","author":"Gowardhan","year":"2007","journal-title":"BJU Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/13645700152601379","article-title":"Temperature measurement in soft tissue using a distributed fibre Bragg-grating sensor system","volume":"10","author":"Samset","year":"2001","journal-title":"Minim. Invasiv. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1088\/0957-0233\/12\/7\/309","article-title":"A fibre optic Bragg grating strain sensor for monitoring ventilatory movements","volume":"12","author":"Wehrle","year":"2001","journal-title":"Meas. Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1109\/JSEN.2011.2158416","article-title":"Medical textiles with embedded fiber optic sensors for monitoring of respiratory movement","volume":"12","author":"Witt","year":"2012","journal-title":"IEEE Sens. J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"De Jonckheere, J., Jeanne, M., Grillet, A., Weber, S., Chaud, P., Logier, R., and Weber, J.L. (2007, January 23\u201326). OFSETH: Optical Fiber Embedded into Technical Textile for Healthcare, An Efficient Way to Monitor Patient under Magnetic Resonance Imaging. Lyon, France.","DOI":"10.1109\/IEMBS.2007.4353198"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"D'Angelo, L.T., Weber, S., Honda, Y., and Thiel, T. (2008, January 20\u201325). A System for Respiratory Motion Detection Using Optical Fibers Embedded into Textiles. Vancouver, BC, Canada.","DOI":"10.1109\/IEMBS.2008.4650011"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Grillet, A., Kinet, D., Witt, J., Schukar, M., Krebber, K., Pirotte, F., and Depr\u00e9, A. (2007, January 4). Optical Fibre Sensors Embedded into Medical Textiles for Monitoring of Respiratory Movements in Mri Environments. Napoli, Italy.","DOI":"10.1117\/12.738631"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1109\/JSEN.2008.926518","article-title":"Optical fiber sensors embedded into medical textiles for healthcare monitoring","volume":"8","author":"Grillet","year":"2008","journal-title":"IEEE Sens. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Silva, A.F., Carmo, J.P., Mendes, P.M., and Correia, J.H. (2011). Simultaneous cardiac and respiratory frequency measurement based on a single fiber Bragg grating sensor. Meas. Sci. Technol, 22.","DOI":"10.1088\/0957-0233\/22\/7\/075801"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"0743011","DOI":"10.1063\/1.3606502","article-title":"Development of optical fiber Bragg grating force-reflection sensor systemof medical application for safe minimally invasive robotic surgery","volume":"82","author":"Song","year":"2011","journal-title":"Rev. Sci. Instrum."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11548-009-0301-6","article-title":"A sub-millimetric, 0.25 mN resolution fully integrated fiber-optic force-sensing tool for retinal microsurgery","volume":"4","author":"Iordachita","year":"2009","journal-title":"Int. J. Comput. Assisted Radiol. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Monfaredi, R., Seifabadi, R., Fichtinger, G., and Iordachita, I. (2013, January 9\u201314). Design of A Decoupled Mri-Compatible Force Sensor Using Fiber Bragg Grating Sensors for Robot-Assisted Prostate Interventions. Lake Buena Vista (Orlando Area), FL, USA.","DOI":"10.1117\/12.2008160"},{"key":"ref_36","unstructured":"Park, Y.L., Elayaperumal, S., Daniel, B.L., Kaye, E., Pauly, K.B., Black, R.J., and Cutkosky, M.R. (, January May). MRI-Compatible Haptics: Feasibility of Using Optical fiber Bragg Grating Strain-Sensors to Detect Deflection of Needles in An MRI Environment. Toronto, ON, Canada."},{"key":"ref_37","first-page":"906","article-title":"Real-time estimation of 3-D needle shape and deflection for MRI-guided interventions","volume":"15","author":"Park","year":"2010","journal-title":"IEEE\/ASME Trans. Mech."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.medengphy.2012.06.014","article-title":"A novel MRI compatible soft tissue indentor and fibre Bragg grating force sensor","volume":"35","author":"Moerman","year":"2013","journal-title":"Med. Eng. Phys."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF02474776","article-title":"Optoelectronic transducer for intravascular measurements of pressure variations","volume":"7","author":"Lekholm","year":"1969","journal-title":"Med. Biol. Eng."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1109\/TIM.2009.2023147","article-title":"Mathematical modeling of intensity-modulated bent-tip optical fiber displacement sensors","volume":"59","author":"Puangmali","year":"2010","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1068-5200(02)00527-8","article-title":"Review of the present status of the optical fiber sensors","volume":"9","author":"Lee","year":"2003","journal-title":"Opt. Fiber Technol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1364\/AO.26.002171","article-title":"Microbend fiber-optic sensor","volume":"26","author":"Lagakos","year":"1987","journal-title":"Appl. Opt."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.3390\/s120302467","article-title":"Interferometric fiber optic sensors","volume":"12","author":"Lee","year":"2012","journal-title":"Sensors"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Tada, M., Sasaki, S., and Ogasawara, T. (2002, January 12\u201314). Development of An Optical 2-Axis Force Sensor Usable in Mri Environments. Orlando, FL, USA.","DOI":"10.1109\/ICSENS.2002.1037244"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1109\/TMECH.2011.2181405","article-title":"Triaxial catheter-tip force sensor for MRI-guided cardiac procedures","volume":"18","author":"Polygerinos","year":"2013","journal-title":"IEEE\/ASME Trans. Mechatron."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1109\/TRO.2010.2090061","article-title":"Tri-axial MRI compatible fiber-optic force sensor","volume":"27","author":"Tan","year":"2011","journal-title":"IEEE Trans. Robot."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Su, H., and Fischer, G.S. (2009, January 9\u201311). A 3-Axis Optical Force\/Torque Sensor for Prostate Needle Placement in Magnetic Resonance Imaging Environments. Woburn, MA, USA,.","DOI":"10.1109\/TEPRA.2009.5339654"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Turkseven, M., and Ueda, J. (2011, January 25\u201330). Design of An MR-Compatible Haptic Interface. San Francisco, CA, USA.","DOI":"10.1109\/IROS.2011.6095170"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3807\/JOSK.2010.14.3.235","article-title":"Development of respiration sensors using plastic optical fiber for respiratory monitoring inside MRI system","volume":"14","author":"Yoo","year":"2010","journal-title":"J. Opt. Soc. Korea"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1109\/10.88443","article-title":"Development of medical pressure and temperature sensors employing optical spectrum modulation","volume":"38","author":"Wolthuis","year":"1991","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jneumeth.2006.07.018","article-title":"Measurement ofblast wave by a miniature fiber optic pressure transducer in the rat brain","volume":"159","author":"Chavko","year":"2007","journal-title":"J. Neurosci. Meth."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1088\/0960-1317\/15\/1\/011","article-title":"Ultra-miniature fibre-optic pressure sensor using white light interferometry","volume":"15","author":"Totsu","year":"2005","journal-title":"J. Micromech. Microeng."},{"key":"ref_53","unstructured":"Su, H., Zervas, M., Furlong, C., and Fischer, G.S. (2011). Mems and Nanotechnology, Springer."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Su, H., Zervas, M., Cole, G.A., Furlong, C., and Fischer, G.S. (2011, January 9\u201313). Real-Time Mri-Guided Needle Placement Robot with Integrated Fiber Optic Force Sensing. Shanghai, China.","DOI":"10.1109\/ICRA.2011.5979539"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1364\/BOE.3.001062","article-title":"Miniature fiber-optic force sensor based on low-coherence Fabry-P\u00e9rot interferometry for vitreoretinal microsurgery","volume":"3","author":"Liu","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ref_56","unstructured":"Magnetic Resonance Imaging Units, Total, OECD iLibrary."},{"key":"ref_57","first-page":"12890","article-title":"M The use of fiber Bragg grating sensors in biomechanics and rehabilitation applications: The state-of-the-art and ongoing research topics","volume":"12","author":"Osman","year":"2007","journal-title":"Sensors"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3390\/s120101002","article-title":"FBG sensor for contact level monitoring and prediction of perforation in cardiac ablation","volume":"12","author":"Ho","year":"2012","journal-title":"Sensors"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/13\/10\/14105\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:49:57Z","timestamp":1760219397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/13\/10\/14105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,18]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10]]}},"alternative-id":["s131014105"],"URL":"https:\/\/doi.org\/10.3390\/s131014105","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,18]]}}}