{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:43:47Z","timestamp":1760708627623,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this article we describe the integration of impedance spectroscopy (EIS) and surface plasmon resonance (SPR) into one surface analytic device. A polydimethylsiloxane (PDMS) flow cell is created, matching the dimensions of a commercially available sensor chip used for SPR measurements. This flow cell allowed simultaneous measurements between an EIS and a SPR setup. After a successful integration, a proof of principle study was conducted to investigate any signs of interference between the two systems during a measurement. The flow cell was rinsed with 10 mM Tris-HCl and 1\u00d7 PBS buffer in an alternating manner, while impedance and shifts of the resonance angle were monitored. After achieving a successful proof of principle, a usability test was conducted. It was assessed whether simultaneous detection occurred when: (i) Protein A is adsorbed to the gold surface of the chip; (ii) The non-occupied zone is blocked with BSA molecules and (iii) IgG1 is bound to the Protein A. The results indicate a successful merge between SPR and EIS.<\/jats:p>","DOI":"10.3390\/s131114650","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T15:39:00Z","timestamp":1383061140000},"page":"14650-14661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Combining Electrochemical Impedance Spectroscopy and Surface Plasmon Resonance into one Simultaneous Read-Out System for the Detection of Surface Interactions"],"prefix":"10.3390","volume":"13","author":[{"given":"Thijs","family":"Vandenryt","sequence":"first","affiliation":[{"name":"Institute for Materials Research IMO, Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium"},{"name":"XIOS University College, Agoralaan building H, 3590 Diepenbeek, Belgium"}]},{"given":"Andrea","family":"Pohl","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Non Destructive Testing (IZFP), Maria-Reiche-Strasse 2, 01109 Dresden, Germany"}]},{"given":"Bart","family":"Van Grinsven","sequence":"additional","affiliation":[{"name":"Institute for Materials Research IMO, Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium"}]},{"given":"Ronald","family":"Thoelen","sequence":"additional","affiliation":[{"name":"Institute for Materials Research IMO, Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium"},{"name":"XIOS University College, Agoralaan building H, 3590 Diepenbeek, Belgium"}]},{"given":"Ward","family":"De Ceuninck","sequence":"additional","affiliation":[{"name":"Institute for Materials Research IMO, Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium"},{"name":"IMEC vzw, IMOMEC, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Patrick","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Materials Research IMO, Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium"},{"name":"IMEC vzw, IMOMEC, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"J\u00f6rg","family":"Opitz","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Non Destructive Testing (IZFP), Maria-Reiche-Strasse 2, 01109 Dresden, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1962.tb13623.x","article-title":"Electrode systems for continuous monitoring in cardiovascular surgery","volume":"102","author":"Clark","year":"1962","journal-title":"Ann. 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