{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:12:03Z","timestamp":1770347523075,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This paper describes an interactive virtual laboratory for experimenting with an outdoor tubular photobioreactor (henceforth PBR for short). This virtual laboratory it makes possible to: (a) accurately reproduce the structure of a real plant (the PBR designed and built by the Department of Chemical Engineering of the University of Almer\u00eda, Spain); (b) simulate a generic tubular PBR by changing the PBR geometry; (c) simulate the effects of changing different operating parameters such as the conditions of the culture (pH, biomass concentration, dissolved O2, inyected CO2, etc.); (d) simulate the PBR in its environmental context; it is possible to change the geographic location of the system or the solar irradiation profile; (e) apply different control strategies to adjust different variables such as the CO2 injection, culture circulation rate or culture temperature in order to maximize the biomass production; (f) simulate the harvesting. In this way, users can learn in an intuitive way how productivity is affected by any change in the design. It facilitates the learning of how to manipulate essential variables for microalgae growth to design an optimal PBR. The simulator has been developed with Easy Java Simulations, a freeware open-source tool developed in Java, specifically designed for the creation of interactive dynamic simulations.<\/jats:p>","DOI":"10.3390\/s140304466","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T10:48:37Z","timestamp":1394102917000},"page":"4466-4483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["An Interactive Tool for Outdoor Computer Controlled Cultivation of Microalgae in a Tubular Photobioreactor System"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-5065","authenticated-orcid":false,"given":"Raquel","family":"Dormido","sequence":"first","affiliation":[{"name":"Department of Computer Sciences and Automatic Control, UNED, C\/Juan del Rosal, 16,  28040 Madrid, Spain"}]},{"given":"Jos\u00e9","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences and Automatic Control, UNED, C\/Juan del Rosal, 16,  28040 Madrid, Spain"}]},{"given":"Natividad","family":"Duro","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences and Automatic Control, UNED, C\/Juan del Rosal, 16,  28040 Madrid, Spain"}]},{"given":"Sebasti\u00e1n","family":"Dormido-Canto","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences and Automatic Control, UNED, C\/Juan del Rosal, 16,  28040 Madrid, Spain"}]},{"given":"Mar\u00eda","family":"Guinaldo","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences and Automatic Control, UNED, C\/Juan del Rosal, 16,  28040 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-8771","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Dormido","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences and Automatic Control, UNED, C\/Juan del Rosal, 16,  28040 Madrid, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jprocont.2011.07.012","article-title":"Hurdles and challenges for modelling and control of microalgae for CO2 mitigation and biofuel production","volume":"21","author":"Bernard","year":"2011","journal-title":"J. Process Contr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biortech.2010.06.048","article-title":"Life cycle assessment of biodiesel production from microalgae in ponds","volume":"102","author":"Campbell","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11157-010-9214-7","article-title":"Commercial application of microalgae other than as biofuels: A brief review","volume":"10","author":"Milledge","year":"2011","journal-title":"Rev. Environ. Sci. Biotechnol."},{"key":"ref_4","unstructured":"Guzm\u00e1n, J.L., Vargas, H., S\u00e1nchez, J., Dormido, S., and Berenguel, M. (2007). Distance Education Issues and Challenges, Nova Science Publishers."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1109\/TE.2007.893356","article-title":"Development of a web-based control laboratory for automation technicians: the three-tank system","volume":"51","author":"Dormido","year":"2008","journal-title":"IEEE Trans. Educ."},{"key":"ref_6","first-page":"1122","article-title":"The role of interactivity in control learning","volume":"21","author":"Dormido","year":"2005","journal-title":"Int. J. Eng. Educ."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Richmond, A. (2004). Handbook of Microalgal Culture: Biotechnology and Applied Phycology, Blackwell Publishing.","DOI":"10.1002\/9780470995280"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1016\/j.biortech.2007.01.046","article-title":"Photobioreactors for mass cultivation of algae","volume":"99","author":"Ugwu","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/bp060065r","article-title":"Microalgal reactors: A review of enclosed system designs and performances","volume":"22","author":"Carvalho","year":"2006","journal-title":"Biotechnol. Prog."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1097-0290(19960705)51:1<51::AID-BIT6>3.0.CO;2-#","article-title":"A flat inclined modular photobioreactor for outdoor mass cultivation of photoautotrophs","volume":"51","author":"Hu","year":"1996","journal-title":"Biotechnol. Bioeng."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0168-1656(00)00353-9","article-title":"Optimization of a flat plate glass reactor for mass production of Nannochloropsis sp. Outdoors","volume":"85","author":"Richmond","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cej.2007.06.004","article-title":"Characterization of a flat plate photobioreactor for the production of microalgae","volume":"138","author":"Sierra","year":"2008","journal-title":"Chem. Eng. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-1656(01)00353-4","article-title":"Tubular photobioreactor design for algal cultures","volume":"92","author":"Molina","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1016\/S0009-2509(00)00521-2","article-title":"Airlift-driven external-loop tubular photobioreactors for outdoor production of microalgae: Assessment of design and performance","volume":"56","author":"Molina","year":"2001","journal-title":"Chem. Eng. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.biotechadv.2012.01.019","article-title":"Closed photobioreactors for production of microalgal biomasses","volume":"30","author":"Wang","year":"2012","journal-title":"Biotechnol. Adv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.biortech.2012.08.087","article-title":"Dynamic model of microalgal production in tubular photobioreactors","volume":"126","author":"Berenguel","year":"2012","journal-title":"Bioresour. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Munner, T. (2004). Solar Radiation and Daylight Models, Elsevier.","DOI":"10.1016\/B978-075065974-1\/50016-4"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/es903214u","article-title":"Mechanistic modeling of broth temperature in outdoor photobioreactors","volume":"44","author":"Shilton","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_19","unstructured":"Astr\u00f6m, K.J., and Wittenmark, B. (1997). Computer Controlled System: Theory Design, Prentice Hall."},{"key":"ref_20","unstructured":"Rodr\u00edguez, C., Fern\u00e1ndez, I., Guzm\u00e1n, J.L., Berenguel, M., and Gabriel, F. (2012, January 6). Puesta en Marcha de un Fotobiorreactor Industrial (in Spanish). Vigo, Spain."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.jprocont.2012.09.005","article-title":"Characterization of symmetric send-on-delta PI controllers","volume":"22","author":"Beschi","year":"2012","journal-title":"J. Process Control"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0010-4655(03)00440-5","article-title":"Easy Java Simulations: A software tool to create scientific simulations in Java","volume":"156","author":"Esquembre","year":"2004","journal-title":"Comput. Phys. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1109\/TLT.2010.35","article-title":"A Network of Automatic Control Web-based Laboratories","volume":"4","author":"Vargas","year":"2011","journal-title":"IEEE Trans. Learn. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1023\/A:1008110819338","article-title":"Scale-up of tubular photobioreactors","volume":"12","author":"Molina","year":"2000","journal-title":"J. Appl. Phycol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00449-013-0928-0","article-title":"Nonlinear predictive control for maximization of CO2, bio-fixation by microalgae in a photobioreactor","volume":"37","author":"Tebbani","year":"2014","journal-title":"Bioprocess Biosyst. Eng."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/3\/4466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:08:58Z","timestamp":1760216938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/3\/4466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3]]}},"alternative-id":["s140304466"],"URL":"https:\/\/doi.org\/10.3390\/s140304466","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]}}}