{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:06:25Z","timestamp":1774951585574,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Sensor performance of a dielectric filled silicon bulk acoustic resonator type label-free biosensor is verified with biotin-streptavidin binding interactions as a model system. The mass sensor is a micromachined silicon square plate with a dielectric filled capacitive excitation mechanism. The resonance frequency of the biotin modified resonator decreased 315 ppm when exposed to streptavidin solution for 15 min with a concentration of 10\u22127 M, corresponding to an added mass of 3.43 ng on the resonator surface.  An additional control is added by exposing a bovine serum albumin (BSA)-covered device  to streptavidin in the absence of the attached biotin. No resonance frequency shift was observed in the control experiment, which confirms the specificity of the detection. The sensor-to-sensor variability is also measured to be 4.3%. Consequently, the developed sensor can be used to observe in biotin-streptavidin interaction without the use of  labelling or molecular tags. In addition, biosensor can be used in a variety of different immunoassay tests.<\/jats:p>","DOI":"10.3390\/s140304585","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T11:44:38Z","timestamp":1394192678000},"page":"4585-4598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biotin-Streptavidin Binding Interactions of Dielectric Filled Silicon Bulk Acoustic Resonators for Smart Label-Free Biochemical Sensor Applications"],"prefix":"10.3390","volume":"14","author":[{"given":"Amir","family":"Heidari","sequence":"first","affiliation":[{"name":"Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR),  Singapore 117685, Singapore"},{"name":"Department of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore"}]},{"given":"Yong-Jin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore"}]},{"given":"Woo-Tae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, Seoul 139743, Korea"}]},{"given":"Pei-Chen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore"}]},{"given":"Jianmin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore"}]},{"given":"Julius","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR),  Singapore 117685, Singapore"},{"name":"InvenSense Inc., San Jose, CA 95110, USA"}]},{"given":"Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Microelectronics, Agency for Science, Technology and Research (A*STAR),  Singapore 117685, Singapore"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Potyrailo, R.A., and Mirsky, V.M. 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