{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:37:10Z","timestamp":1783298230944,"version":"3.54.6"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper we describe a thermal biosensor with a flow injection analysis system for the determination of the chemical oxygen demand (COD) of water samples. Glucose solutions of different concentrations and actual water samples were tested, and their COD values were determined by measuring the heat generated when the samples passed through a column containing periodic acid. The biosensor exhibited a large linear range (5 to 3000 mg\/L) and a low detection limit (1.84 mg\/L). It could tolerate the presence of chloride ions in concentrations of 0.015 M without requiring a masking agent. The sensor was successfully used for detecting the COD values of actual samples. The COD values of water samples from various sources were correlated with those obtained by the standard dichromate method; the linear regression coefficient was found to be 0.996. The sensor is environmentally friendly, economical, and highly stable, and exhibits good reproducibility and accuracy. In addition, its response time is short, and there is no danger of hazardous emissions or external contamination. Finally, the samples to be tested do not have to be pretreated. These results suggest that the biosensor is suitable for the continuous monitoring of the COD values of actual wastewater samples.<\/jats:p>","DOI":"10.3390\/s140609949","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T10:37:33Z","timestamp":1402051053000},"page":"9949-9960","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Rapid Determination of the Chemical Oxygen Demand of Water Using a Thermal Biosensor"],"prefix":"10.3390","volume":"14","author":[{"given":"Na","family":"Yao","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/s11164-012-0545-6","article-title":"Condition optimization of amperometric determination of chemical oxygen demand using boron-doped diamond sensor","volume":"38","author":"Wang","year":"2012","journal-title":"Res. 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