{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:19:46Z","timestamp":1775618386050,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this work we present the first steps towards a molecularly imprinted  polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 \u03bcL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications.<\/jats:p>","DOI":"10.3390\/s140611016","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T11:34:08Z","timestamp":1403264048000},"page":"11016-11030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Array Formatting of the Heat-Transfer Method (HTM) for  the Detection of Small Organic Molecules by Molecularly Imprinted Polymers"],"prefix":"10.3390","volume":"14","author":[{"given":"Gideon","family":"Wackers","sequence":"first","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Thijs","family":"Vandenryt","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Peter","family":"Cornelis","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Evelien","family":"Kellens","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6845-0866","authenticated-orcid":false,"given":"Ronald","family":"Thoelen","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Ward","family":"De Ceuninck","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Patricia","family":"Losada-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6939-0866","authenticated-orcid":false,"given":"Bart","family":"Van Grinsven","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"Maastricht Science Programme, Maastricht University, 6200 MD Maastricht, The Netherlands"}]},{"given":"Marloes","family":"Peeters","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]},{"given":"Patrick","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Materials Research, Hasselt University, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"},{"name":"IMEC vzw\u2014Division IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.aca.2009.07.043","article-title":"Use of a bisphenol-A imprinted polymer as a selective sorbent for the determination of phenols and phenoxyacids in honey by liquid chromatography with diode array and tandem mass spectrometric detection","volume":"650","year":"2009","journal-title":"Anal. 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