{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:49:49Z","timestamp":1774414189547,"version":"3.50.1"},"reference-count":114,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Dysregulation of neurotransmitters (NTs) in the human body are related to diseases such as Parkinson\u2019s and Alzheimer\u2019s. The mechanisms of several neurological disorders, such as epilepsy, have been linked to NTs. Because the number of diagnosed cases is increasing, the diagnosis and treatment of such diseases are important. To detect biomolecules including NTs, microtechnology, micro and nanoelectronics have become popular in the form of the miniaturization of medical and clinical devices. They offer  high-performance features in terms of sensitivity, as well as low-background noise. In this paper, we review various devices and circuit techniques used for monitoring NTs in vitro and in vivo and compare various methods described in recent publications.<\/jats:p>","DOI":"10.3390\/s141017981","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T11:27:58Z","timestamp":1411730878000},"page":"17981-18008","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Microelectronics-Based Biosensors Dedicated to the Detection of Neurotransmitters: A Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Maryam","family":"Mirzaei","sequence":"first","affiliation":[{"name":"Polystim Neurotechnologies Laboratory, Electrical Engineering Department, Polytechnique Montreal, Montreal, QC H3T1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Sawan","sequence":"additional","affiliation":[{"name":"Polystim Neurotechnologies Laboratory, Electrical Engineering Department, Polytechnique Montreal, Montreal, QC H3T1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"ref_1","unstructured":"First Official Purple Day in Canada Brings Epilepsy Awareness to Parliament Hill. Available online: http:\/\/www.epilepsymatters.com\/english\/index.html."},{"key":"ref_2","unstructured":"Facts about Parkinson's. Available online: http:\/\/www.parkinson.bc.ca\/Parkinsons-Disease-Fact-Sheet."},{"key":"ref_3","first-page":"S339","article-title":"The growing burden of Alzheimer's disease","volume":"17","author":"Lopez","year":"2011","journal-title":"Am. J. Manag. Care"},{"key":"ref_4","first-page":"3414","article-title":"Specific needs of dopamine neurons for stimulation in order to survive: Implication for Parkinson disease","volume":"27","author":"Michel","year":"2013","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2012.10.017","article-title":"Highly sensitive trivalent copper chelate-luminol chemiluminescence system for capillary electrophoresis detection of epinephrine in the urine of smoker","volume":"911","author":"Li","year":"2012","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneumeth.2010.04.023","article-title":"Collection of nanoliter microdialysate fractions in plugs for off-line in vivo chemical monitoring with up to 2 s temporal resolution","volume":"190","author":"Wang","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1021\/ac302403e","article-title":"Mass spectrometric detection of neuropeptides using affinity-enhanced microdialysis with antibody-coated magnetic nanoparticles","volume":"85","author":"Schmerberg","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1039\/c3lc41334a","article-title":"Microfluidic systems for studying neurotransmitters and neurotransmission","volume":"13","author":"Croushore","year":"2013","journal-title":"Lab Chip"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neubiorev.2010.07.007","article-title":"Neurotransmitters excreted in the urine as biomarkers of nervous system activity: Validity and clinical applicability","volume":"35","author":"Marc","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1039\/c2lc90052a","article-title":"Lab on a chip: United States of America","volume":"12","author":"Ingber","year":"2012","journal-title":"Lab Chip"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2009.07.064","article-title":"Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review","volume":"651","author":"Nandi","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/elps.200900612","article-title":"Development of a PDMS-based microchip electrophoresis device for continuous online in vivo monitoring of microdialysis samples","volume":"31","author":"Nandi","year":"2010","journal-title":"Electrophoresis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1021\/ac051044z","article-title":"Microfluidic electrophoresis chip coupled to microdialysis for in vivo monitoring of amino acid neurotransmitters","volume":"77","author":"Sandlin","year":"2005","journal-title":"Anal. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10544-005-6173-9","article-title":"Microdialysis microneedles for continuous medical monitoring","volume":"7","author":"Zahn","year":"2005","journal-title":"Biomed. Microdevices"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1021\/ac3035794","article-title":"Immobilization method to preserve enzyme specificity in biosensors: Consequences for brain glutamate detection","volume":"85","author":"Vasylieva","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rothe, J., Lewandowska, M.K., Heer, F., Frey, O., and Hierlemann, A. (2011). Multi-Target electrochemical biosensing enabled by integrated CMOS electronics. J. Micromech. Microeng., 21.","DOI":"10.1088\/0960-1317\/21\/5\/054010"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bios.2005.02.008","article-title":"Novel micromachined silicon sensor for continuous glucose monitoring","volume":"21","author":"Piechotta","year":"2005","journal-title":"Biosens. Bioelectron."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/clinchem\/20.8.992","article-title":"Electrochemical detection of selected organic components in the eluate from high-performance liquid-chromatography","volume":"20","author":"Kissinger","year":"1974","journal-title":"Clin. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kang, W.P., Raina, S., Davidson, J.L., and Huang, J.H. (2012, January 28\u201331). High temporal resolution electrochemical biosensor using nitrogen-incorporated nanodiamond ultra-microelectrode array. Taipei, Taiwan.","DOI":"10.1109\/ICSENS.2012.6411339"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/157341111793797671","article-title":"The recent electrochemical biosensor technologies for monitoring of nucleic acid hybridization","volume":"7","author":"Karadeniz","year":"2011","journal-title":"Curr. Anal. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1126A","DOI":"10.1021\/ac50008a001","article-title":"Probing brain chemistry with electroanalytical techniques","volume":"48","author":"Adams","year":"1976","journal-title":"Anal. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aca.2010.01.009","article-title":"Review: Carbon nanotube based electrochemical sensors for biomolecules","volume":"662","author":"Jacobs","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1021\/ac302134s","article-title":"RNA aptamer-based electrochemical biosensor for selective and label-free analysis of dopamine","volume":"85","author":"Farjami","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/elan.201200542","article-title":"Biosensor based on electrocodeposition of carbon nanotubes\/polypyrrole\/laccase for neurotransmitter detection","volume":"25","author":"Cesarino","year":"2013","journal-title":"Electroanal"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.elecom.2004.12.015","article-title":"Electrochemical biosensor based on protein-polysaccharide hybrid for selective detection of nanomolar dopamine metabolite of 3,4-dihydroxyphenylacetic acid (DOPAC)","volume":"7","author":"Liu","year":"2005","journal-title":"Electrochem. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1002\/1522-2683(200211)23:21<3649::AID-ELPS3649>3.0.CO;2-O","article-title":"Amperometric and voltammetric detection for capillary electrophoresis","volume":"23","author":"Holland","year":"2002","journal-title":"Electrophoresis"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wang, H. (2011, January 7\u201310). Integrated biosensors in CMOS. Seoul, Korea.","DOI":"10.1109\/MWSCAS.2011.6026339"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/1521-4109(200103)13:3<173::AID-ELAN173>3.0.CO;2-B","article-title":"Capacitive biosensors","volume":"13","author":"Berggren","year":"2001","journal-title":"Electroanalysis"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1021\/ac2011729","article-title":"Head-to-Head comparisons of carbon fiber microelectrode coatings for sensitive and selective neurotransmitter detection by voltammetry","volume":"83","author":"Singh","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jelechem.2012.07.014","article-title":"Implantable microprobe with arrayed microsensors for combined amperometric monitoring of the neurotransmitters, glutamate and dopamine","volume":"682","author":"Tseng","year":"2012","journal-title":"J. Electroanal. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1021\/ac103092z","article-title":"Analysis of biogenic amines in a single drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection","volume":"83","author":"Fang","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1039\/c0cp00675k","article-title":"Trace voltammetric detection of serotonin at carbon electrodes: Comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes","volume":"12","author":"Meadows","year":"2010","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"H765","DOI":"10.1149\/2.004210jes","article-title":"Electrochemical Determination of neurotransmitters using gold nanoparticles on nafion\/carbon paste modified electrode","volume":"159","author":"Atta","year":"2012","journal-title":"J. Electrochem. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1039\/c1ay05348e","article-title":"Comparison of Nafion- and overoxidized polypyrrole-carbon nanotube electrodes for neurotransmitter detection","volume":"3","author":"Peairs","year":"2011","journal-title":"Anal. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0731-7085(98)00129-0","article-title":"Chemical and biochemical sensors based on advances in materials chemistry","volume":"19","author":"Tess","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bios.2012.04.005","article-title":"Preparation of thiolated polymeric nanocomposite for sensitive electroanalysis of dopamine","volume":"36","author":"Su","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jelechem.2012.08.003","article-title":"Influence of different biological environments on the stability of serotonin detection on carbon-based electrodes","volume":"684","author":"Watt","year":"2012","journal-title":"J. Electroanal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1080\/00032710903521900","article-title":"Selective DPV method of dopamine determination in biological samples containing ascorbic acid","volume":"43","author":"David","year":"2010","journal-title":"Anal. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.snb.2010.02.048","article-title":"Highly selective determination of ascorbic acid, dopamine, and uric acid by differential pulse voltammetry using poly(sulfonazo III) modified glassy carbon electrode","volume":"147","author":"Ensafi","year":"2010","journal-title":"Sens. Actuators B Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jelechem.2013.01.022","article-title":"Microfabricated microelectrode sensor for measuring background and slowly changing dopamine concentrations","volume":"693","author":"Dengler","year":"2013","journal-title":"J. Electroanal. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1007\/s00216-011-5696-6","article-title":"Electrochemically synthesized polymers in molecular imprinting for chemical sensing","volume":"402","author":"Sharma","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1039\/c0an00114g","article-title":"Microfabricated FSCV-compatible microelectrode array for real-time monitoring of heterogeneous dopamine release","volume":"135","author":"Zachek","year":"2010","journal-title":"Analyst"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nmeth.1412","article-title":"Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals","volume":"7","author":"Clark","year":"2009","journal-title":"Nat. Methods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1109\/JSEN.2011.2173674","article-title":"An integrated flexible implantable micro-probe for sensing neurotransmitters","volume":"12","author":"Cao","year":"2012","journal-title":"IEEE Sens. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3171\/2009.7.JNS09787","article-title":"Comonitoring of adenosine and dopamine using the Wireless Instantaneous Neurotransmitter Concentration System: Proof of principle","volume":"112","author":"Shon","year":"2010","journal-title":"J. Neurosurg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.snb.2011.07.052","article-title":"Modification of platinum microelectrode with molecularly imprinted over-oxidized polypyrrole for dopamine measurement in rat striatum","volume":"171","author":"Tsai","year":"2012","journal-title":"Sens. Actuators B Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"F116","DOI":"10.1149\/1.3456629","article-title":"Carbon paste gold nanoparticles sensor for the selective determination of dopamine in buffered solutions","volume":"157","author":"Atta","year":"2010","journal-title":"J. Electrochem. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12955","DOI":"10.1016\/S1452-3981(23)16599-0","article-title":"Poly(3-thiophenemalonic acid) modified glassy carbon electrode for selective determination of dopamine and urine acid in the presence of ascorbic acid","volume":"7","author":"Wan","year":"2012","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1039\/C0AY00445F","article-title":"Application of multiway-variate calibration to simultaneous voltammetric determination of three catecholamines","volume":"3","author":"Ni","year":"2011","journal-title":"Anal. Methods"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1109\/JSEN.2011.2163708","article-title":"Characterization of novel microelectrode geometries for detection of neurotransmitters","volume":"12","author":"Pettine","year":"2012","journal-title":"IEEE Sens. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1021\/ac4009385","article-title":"Individually addressable thin-film ultramicroelectrode array for spatial measurements of single vesicle release","volume":"85","author":"Wang","year":"2013","journal-title":"Anal. Chem"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/jpet.110.178384","article-title":"Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: Role of voltage-sensitive Ca2+ alpha(2)delta-1 subunit","volume":"338","author":"Quintero","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1471-4159.2011.07494.x","article-title":"In vivo comparison of norepinephrine and dopamine release in rat brain by simultaneous measurements with fast-scan cyclic voltammetry","volume":"119","author":"Park","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12035-013-8531-6","article-title":"Carbon nanofiber electrode for neurochemical monitoring","volume":"48","author":"Zhang","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"10344","DOI":"10.1021\/ac402263x","article-title":"Flexible software platform for fast-scan cyclic voltammetry data acquisition and analysis","volume":"85","author":"Bucher","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_56","first-page":"1085","article-title":"A molecule-imprinted polyaniline membrane modified on carbon fiber for detection of glycine","volume":"24","author":"Zeng","year":"2014","journal-title":"BioMed. Mater. Eng."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1039\/C1AN15746A","article-title":"Electrochemical sensor for neurotransmitters at physiological pH using a heterocyclic conducting polymer modified electrode","volume":"137","author":"Revin","year":"2012","journal-title":"Analyst"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1098\/rsfs.2011.0049","article-title":"Nanocapillary electrophoretic electrochemical chip: Towards analysis of biochemicals released by single cells","volume":"1","author":"Wu","year":"2011","journal-title":"Interface Focus"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10337-012-2378-2","article-title":"Simultaneous determination of neuroactive amino acids in serum by CZE coupled with amperometric detection","volume":"76","author":"Ge","year":"2013","journal-title":"Chromatographia"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1523\/JNEUROSCI.5062-12.2013","article-title":"Amperometric resolution of a prespike stammer and evoked phases of fast release from retinal bipolar cells","volume":"33","author":"Grabner","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.aca.2011.03.057","article-title":"Chitosan coated carbon fiber microelectrode for selective in vivo detection of neurotransmitters in live zebrafish embryos","volume":"695","author":"Ozel","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bej.2013.04.019","article-title":"Selective enzyme immobilization on arrayed microelectrodes for the application of sensing neurotransmitters","volume":"78","author":"Tseng","year":"2013","journal-title":"Biochem. Eng. J."},{"key":"ref_63","first-page":"8253","article-title":"Amperometric tyrosinase based biosensors for serotonin detection","volume":"18","author":"Apetrei","year":"2013","journal-title":"Rom. Biotechnol. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"17560","DOI":"10.1039\/c2jm33013j","article-title":"Fabrication, characterization and application of a grafting based gold nanoparticles electrode for the selective determination of an important neurotransmitter","volume":"22","author":"Kesavan","year":"2012","journal-title":"J. Mater Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bios.2013.08.054","article-title":"Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments","volume":"52","author":"Ozel","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1039\/c2an35964b","article-title":"Interfacial Janus gold nanoclusters as excellent phase- and orientation-specific dopamine sensors","volume":"137","author":"Biji","year":"2012","journal-title":"Analyst"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1152\/jn.00620.2011","article-title":"In vivo voltammetry monitoring of electrically evoked extracellular norepinephrine in subregions of the bed nucleus of the stria terminalis","volume":"107","author":"Herr","year":"2012","journal-title":"J. Neurophysiol."},{"key":"ref_68","unstructured":"Azzopardi, C., Azzopardi, M., Muscat, R., and Camilleri, K.P. (September, January 28). Investigating linear superposition of multi-species neurotransmitter voltammetric measurements in-vitro. San Diego, CA, USA."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bios.2012.09.061","article-title":"Amplified voltammetric detection of dopamine using ferrocene-capped gold nanoparticle\/streptavidin conjugates","volume":"41","author":"Liu","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/354056a0","article-title":"Helical microtubules of graphitic carbon","volume":"354","author":"Iijima","year":"1991","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11434-011-4845-9","article-title":"Carbon nanotubes in biology and medicine: An overview","volume":"57","author":"Wang","year":"2012","journal-title":"Chin. Sci. Bull."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.cap.2008.08.031","article-title":"Neurotransmitter detection by enzyme-immobilized CNT-FET","volume":"9","author":"Lee","year":"2009","journal-title":"Curr. Appl. Phys."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1021\/ac301445w","article-title":"Rapid, sensitive detection of neurotransmitters at microelectrodes modified with self-assembled SWCNT forests","volume":"84","author":"Xiao","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bios.2011.10.002","article-title":"Mediator-Less highly sensitive voltammetric detection of glutamate using glutamate dehydrogenase\/vertically aligned CNTs grown on silicon substrate","volume":"31","author":"Gholizadeh","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1039\/c0an00854k","article-title":"Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes","volume":"136","author":"Jacobs","year":"2011","journal-title":"Analyst"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1021\/ac902465v","article-title":"Electrochemical quantification of serotonin in the live embryonic zebrafish intestine","volume":"82","author":"Njagi","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.electacta.2010.12.047","article-title":"A novel multi-walled carbon nanotube modified sensor for the selective determination of epinephrine in smokers","volume":"56","author":"Goyal","year":"2011","journal-title":"Electrochim. Acta"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.talanta.2010.12.034","article-title":"Simultaneous determination of epinephrine and norepinephrine in human blood plasma and urine samples using nanotubes modified edge plane pyrolytic graphite electrode","volume":"84","author":"Goyal","year":"2011","journal-title":"Talanta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1590\/S0103-50532011000300009","article-title":"Electroless deposition of bis(4\u2032-(4-Pyridyl)-2,2\u2032: 6\u2032, 2\u2033-terpyridine)iron(II) thiocyanate complex onto carbon nanotubes modified glassy carbon electrode: Application to simultaneous determination of ascorbic acid, dopamine and uric acid","volume":"22","author":"Kamyabi","year":"2011","journal-title":"J Brazil Chem. Soc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/cjoc.201180374","article-title":"A sensitive simultaneous determination of adrenalin and paracetamol on a glassy carbon electrode coated with a film of chitosan\/room temperature ionic liquid\/single-walled carbon nanotubes nanocomposite","volume":"29","author":"Babaei","year":"2011","journal-title":"Chin. J. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1039\/c1an15025a","article-title":"Carbon nanofiber electrode array for electrochemical detection of dopamine using fast scan cyclic voltammetry","volume":"136","author":"Koehne","year":"2011","journal-title":"Analyst"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3171\/2009.3.JNS081348","article-title":"Development of the Wireless Instantaneous Neurotransmitter Concentration System for intraoperative neurochemical monitoring using fast-scan cyclic voltammetry. Technical note","volume":"111","author":"Bledsoe","year":"2009","journal-title":"J. Neurosurg."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1021\/am302902d","article-title":"Are carbon nanotubes a natural solution? Applications in biology and medicine","volume":"5","author":"Heister","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.addr.2013.11.002","article-title":"Carbon nanotubes in medicine & biology\u2014Therapy and diagnostics","volume":"65","author":"Kostarelos","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12274-009-9009-8","article-title":"Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery","volume":"2","author":"Liu","year":"2009","journal-title":"Nano Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1016\/j.bios.2011.04.061","article-title":"A cyclodextrin host-guest recognition approach to an electrochemical sensor for simultaneous quantification of serotonin and dopamine","volume":"26","author":"Abbaspour","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1080\/00032719.2012.673104","article-title":"Determination of epinephrine in carp brain cells by square-wave anodic stripping voltammetry with carbon nanotubes","volume":"45","author":"Ly","year":"2012","journal-title":"Anal. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1039\/c2an35297d","article-title":"Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine","volume":"137","author":"Ross","year":"2012","journal-title":"Analyst"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00604-010-0484-0","article-title":"New integrated in vivo microdialysis-electrochemical device for determination of the neurotransmitter dopamine in rat striatum of freely moving rats","volume":"172","author":"Lin","year":"2011","journal-title":"Microchim. Acta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"16034","DOI":"10.1021\/ja408485m","article-title":"An ultrasensitive nanowire-transistor biosensor for detecting dopamine release from living PC12 cells under hypoxic stimulation","volume":"135","author":"Li","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mejo.2008.07.001","article-title":"Adaptive CMOS analog circuits for 4G mobile terminals-review and state-of-the-art survey","volume":"40","author":"Morgado","year":"2009","journal-title":"Microelectron. J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.3390\/s120810042","article-title":"CMOS cell sensors for point-of-care diagnostics","volume":"12","author":"Adiguzel","year":"2012","journal-title":"Sensors"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.3390\/s91109073","article-title":"Implantable CMOS biomedical devices","volume":"9","author":"Ohta","year":"2009","journal-title":"Sensors"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.3390\/s110504943","article-title":"Commercialisation of CMOS integrated circuit technology in multi-electrode arrays for neuroscience and cell-based biosensors","volume":"11","author":"Graham","year":"2011","journal-title":"Sensors"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1021\/cr068113+","article-title":"Chemical sensors with integrated electronics","volume":"108","author":"Joo","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Thewes, R. (2007, January 26\u201327). CMOS chips for bio molecule sensing purposes. Bari, Italy.","DOI":"10.1109\/IWASI.2007.4420000"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1109\/TBME.2005.847523","article-title":"Impedance characterization and modeling of electrodes for biomedical applications","volume":"52","author":"Franks","year":"2005","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.bios.2010.08.065","article-title":"5 \u00d7 5 CMOS capacitive sensor array for detection of the neurotransmitter dopamine","volume":"26","author":"Lu","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1109\/TBCAS.2009.2033706","article-title":"Post-CMOS fabrication of working electrodes for on-chip recordings of transmitter release","volume":"4","author":"Ayers","year":"2010","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1109\/JSEN.2010.2041447","article-title":"CMOS capacitive sensors with sub-mu m microelectrodes for biosensing applications","volume":"10","author":"Wang","year":"2010","journal-title":"IEEE Sens. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bios.2012.09.058","article-title":"Parallel recording of neurotransmitters release from chromaffin cells using a 10 \u00d7 10 CMOS IC potentiostat array with on-chip working electrodes","volume":"41","author":"Kim","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Nazari, M.H., Mazhab-Jafari, H., Guenther, A., and Genov, R. (2010, January 19\u201322). 192-Channel CMOS neurochemical microarray. San Jose CA USA.","DOI":"10.1109\/CICC.2010.5617606"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Poustinchi, M., and Musallam, S. (2011, January 27April\u20131). Low power noise immune circuit for implantable CMOS neurochemical sensor applied in neural prosthetics. Cancun, Mexico.","DOI":"10.1109\/NER.2011.5910643"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bios.2011.11.015","article-title":"Modification of standard CMOS technology for cell-based biosensors","volume":"31","author":"Graham","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1109\/TIE.2008.2011450","article-title":"Biosensor systems in standard CMOS processes: Fact or fiction?","volume":"56","author":"Jang","year":"2009","journal-title":"IEEE Trans. Ind. Electron."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1109\/JSEN.2011.2105260","article-title":"Electrochemical detection of the neurotransmitter dopamine by nanoimprinted interdigitated electrodes and a CMOS circuit with enhanced collection efficiency","volume":"11","author":"Huang","year":"2011","journal-title":"IEEE Sens. J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1039\/b916975j","article-title":"Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter","volume":"10","author":"Lee","year":"2010","journal-title":"Lab Chip"},{"key":"ref_108","unstructured":"Miled, M.A., and Sawan, M. (September, January 28). Electrode robustness in artificial cerebrospinal fluid for dielectrophoresis-based LoC. San Diego, CA, USA."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1109\/TBCAS.2012.2185844","article-title":"Dielectrophoresis-based integrated lab-on-chip for nano and micro-particles manipulation and capacitive detection","volume":"6","author":"Miled","year":"2012","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_110","first-page":"1","article-title":"A New Fully Differential Capacitance to Digital Converter for Lab-on-Chip Based Sensing Applications","volume":"99","author":"Nabovati","year":"2014","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Massicotte, G., and Sawan, M. (2013, January 4\u20135). An Efficient Time-Based CMOS Potentiostat for Neurotransmitters Sensing. Gatineau, QC, Canada.","DOI":"10.1109\/MeMeA.2013.6549751"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/jcem-69-4-753","article-title":"Epinephrine kinetics in humans: Radiotracer methodology","volume":"69","author":"Rosen","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1124\/jpet.103.049270","article-title":"Sources and significance of plasma levels of catechols and their metabolites in humans","volume":"305","author":"Goldstein","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_114","first-page":"847069","article-title":"First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy","volume":"2013","author":"Rouzaud","year":"2013","journal-title":"BioMed. Res. Int."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/10\/17981\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:16:21Z","timestamp":1760217381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/10\/17981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,26]]},"references-count":114,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10]]}},"alternative-id":["s141017981"],"URL":"https:\/\/doi.org\/10.3390\/s141017981","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,26]]}}}