{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:45:50Z","timestamp":1781883950710,"version":"3.54.5"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Radix Angelicae Sinensis, known as Danggui in China, is an effective and wide applied material in Traditional Chinese Medicine (TCM) and it is used in more than  80 composite formulae. Danggui from Minxian County, Gansu Province is the best in quality. To rapidly and nondestructively discriminate Danggui from the authentic region of origin from that from an unauthentic region, an electronic nose coupled with multivariate statistical analyses was developed. Two different feature extraction methods were  used to ensure the authentic region and unauthentic region of Danggui origin could be discriminated. One feature extraction method is to capture the average value of the maximum response of the electronic nose sensors (feature extraction method 1). The other one is to combine the maximum response of the sensors with their inter-ratios (feature extraction method 2). Multivariate statistical analyses, including principal component analysis (PCA), soft independent modeling of class analogy (SIMCA), and hierarchical clustering analysis (HCA) were employed. Nineteen samples were analyzed by PCA, SIMCA and HCA. Then the remaining samples (GZM1, SH) were projected onto the SIMCA model to validate the models. The results indicated that, in the use of feature extraction method 2, Danggui from Yunnan Province and Danggui from Gansu Province could be successfully discriminated using the electronic nose coupled with PCA, SIMCA and HCA, which suggested that the electronic-nose system could be used as a simple and rapid technique for the discrimination of Danggui between authentic and unauthentic region of origin.<\/jats:p>","DOI":"10.3390\/s141120134","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T11:38:09Z","timestamp":1414409889000},"page":"20134-20148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Rapid Discrimination of Authentic and Unauthentic Radix Angelicae Sinensis Growth Regions by Electronic Nose Coupled with Multivariate Statistical Analyses"],"prefix":"10.3390","volume":"14","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.6 Wangjing Zhonghuan South Road, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Forensic Science, Ministry of Public Security, No.17 Muxidi South Street Xicheng District, Beijing 100038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojun","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.6 Wangjing Zhonghuan South Road, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.6 Wangjing Zhonghuan South Road, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.6 Wangjing Zhonghuan South Road, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.6 Wangjing Zhonghuan South Road, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Ren","sequence":"additional","affiliation":[{"name":"Yinkou Institute For Drug, NO.29 Qinghua West Street, Xishi District, Yingkou 115100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.3390\/molecules14125349","article-title":"Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui)","volume":"14","author":"Li","year":"2009","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.chroma.2008.07.033","article-title":"The analysis of Radix Angelicae Sinensis (Danggui)","volume":"1216","author":"Yi","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jep.2012.02.018","article-title":"Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry","volume":"141","author":"Zhou","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1002\/rcm.3638","article-title":"Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography\/diode-array detection coupled with time-of-flight mass spectrometry","volume":"22","author":"Qi","year":"2008","journal-title":"Rapid Commun. Mass Sp."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/13880209.2013.805790","article-title":"HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics","volume":"52","author":"Zhang","year":"2014","journal-title":"Pharm. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/jssc.200600136","article-title":"Separation and identification of the organic acids in Angelicae Radix and Ligustici Rhizoma by HPLC and CE","volume":"29","author":"Huang","year":"2006","journal-title":"J. Sep. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.3390\/s110606435","article-title":"An Electronic Nose for Reliable Measurement and Correct Classification of Beverages","volume":"11","author":"Mamat","year":"2011","journal-title":"Sensors"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.3390\/s110505005","article-title":"Electronic Nose Based on an Optimized Competition Neural Network","volume":"11","author":"Men","year":"2011","journal-title":"Sensors"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0925-4005(03)00321-6","article-title":"The electronic nose applied to dairy products: A review","volume":"94","author":"Ampuero","year":"2003","journal-title":"Sens. Actuators B Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/S0043-1354(00)00530-3","article-title":"The electronic nose as a rapid sensor for volatile compounds in treated domestic wastewater","volume":"35","author":"Dewettinck","year":"2001","journal-title":"Water Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpba.2013.05.027","article-title":"Rapid discrimination of Apiaceae plants by electronic nose coupled with multivariate statistical analyses","volume":"84","author":"Lin","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jpba.2011.03.018","article-title":"Can odors of TCM be captured by electronic nose? The novel quality control method for musk by electronic nose coupled with chemometrics","volume":"55","author":"Ye","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/wics.101","article-title":"Principal component analysis","volume":"2","author":"Abdi","year":"2010","journal-title":"Wiley Interdiscip. Rev. Comput. Stat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1198\/106186006X113430","article-title":"Sparse Principal Component Analysis","volume":"15","author":"Zou","year":"2006","journal-title":"J Comput. Graph. Stat."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1021\/es204187r","article-title":"Application of PCA and SIMCA Statistical Analysis of FT-IR Spectra for the Classification and Identification of Different Slag Types with Environmental Origin","volume":"46","author":"Stumpe","year":"2012","journal-title":"Environm. Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jpba.2012.06.009","article-title":"Rapid discrimination of Chinese red ginseng and Korean ginseng using an electronic nose coupled with chemometrics","volume":"70","author":"Li","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbamem.2006.05.001","article-title":"Identification of primary tumors of brain metastases by SIMCA classification of IR spectroscopic images","volume":"1758","author":"Krafft","year":"2006","journal-title":"Bba-Biomembranes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/cem.1006","article-title":"OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification","volume":"20","author":"Bylesjo","year":"2006","journal-title":"J Chemom."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/11\/20134\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:17:26Z","timestamp":1760217446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/11\/20134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,27]]},"references-count":18,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11]]}},"alternative-id":["s141120134"],"URL":"https:\/\/doi.org\/10.3390\/s141120134","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,27]]}}}