{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:56:44Z","timestamp":1789646204247,"version":"4.0.0"},"reference-count":27,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A new fluorescent probe P derived from naphthalimide bearing a pyridine group has been synthesized and characterized. The proposed probe P shows high selectivity and sensitivity to Cu2+ in aqueous media. Under optimized conditions, the linear response of P (2 \u03bcM) toward Cu2+ was 0.05\u20130.9 \u03bcM in ethanol-water solution (3:2, v:v, 50 mM HEPES, pH 7.4), and the detection limit was 0.03 \u03bcM.<\/jats:p>","DOI":"10.3390\/s141224146","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T10:25:19Z","timestamp":1418639119000},"page":"24146-24155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Pyridine-Containing Cu2+-Selective Probe Based on Naphthalimide Derivative"],"prefix":"10.3390","volume":"14","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine,  Hainan Medical University, Haikou 571101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Laboratory Medicine, School of Tropical and Laboratory Medicine,  Hainan Medical University, Haikou 571101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangliang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hainan Medical University, Haikou 571101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine,  Hainan Medical University, Haikou 571101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/cr078203u","article-title":"Metals in neurobiology: Probing their chemistry and biology with molecular imaging","volume":"108","author":"Que","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1039\/c0ob00553c","article-title":"Highly sensitive and selective colorimetric and off-on fluorescent probe for Cu2+ based on rhodamine derivative","volume":"8","author":"Yu","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.saa.2012.12.005","article-title":"Highly selective fluorescence turn-on chemosensor based on naphthalimide derivatives for detection of copper(II) ions","volume":"105","author":"Chen","year":"2013","journal-title":"Spectrochim. Acta Part A"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.dyepig.2011.09.020","article-title":"A selective fluorescent chemosensor with 1, 2, 4-triazole as subunit for Cu(II) and its application in imaging Cu(II) in living cells","volume":"92","author":"Zhang","year":"2012","journal-title":"Dyes Pigm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.snb.2014.01.116","article-title":"A BODIPY-based \u201cturn-on\u201d fluorescent and colorimetric sensor for selective detection of Cu2+ in aqueous media and its application in cell imaging","volume":"196","author":"Zhang","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ica.2011.07.039","article-title":"A colorimetric probe for copper(II) ion based on 4-amino-1, 8-naphthalimide","volume":"381","author":"Wang","year":"2012","journal-title":"Inorg. Chim. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.tet.2010.01.008","article-title":"Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach","volume":"66","author":"Xu","year":"2010","journal-title":"Tetrahedron"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.snb.2014.06.125","article-title":"Rhodamine-triazine based probes for Cu2+ in aqueous media and living cells","volume":"204","author":"Zhang","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1039\/c4dt00014e","article-title":"A naphthalimide-based bifunctional fluorescent probe for the differential detection of Hg2+ and Cu2+ in aqueous solution","volume":"43","author":"Huang","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.snb.2009.02.010","article-title":"New fluorescent and colorimetric chemosensors bearing rhodamine and binaphthyl groups for the detection of Cu2+","volume":"137","author":"Chen","year":"2009","journal-title":"Sens. Actuators B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/ol3032889","article-title":"A fluorescent ratiometric chemodosimeter for Cu2+ based on TBET and its application in living cells","volume":"15","author":"Fan","year":"2013","journal-title":"Org. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.dyepig.2010.07.004","article-title":"Sulfonyl rhodamine hydrazide: A sensitive and selective chromogenic and fluorescent chemodosimeter for copper ion in aqueous media","volume":"88","author":"Hu","year":"2011","journal-title":"Dyes Pigm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1021\/ac901127n","article-title":"Highly sensitive and selective colorimetric and off-on fluorescent probe for Cu2+ in aqueous solution and living cells","volume":"81","author":"Zhao","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00604-011-0623-2","article-title":"Fluorescent probe for copper(II) ion based on a rhodamine spirolactame derivative and its application to fluorescent imaging in living cells","volume":"174","author":"Yu","year":"2011","journal-title":"Microchim. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.1039\/c0dt00606h","article-title":"A new rhodamine-based chemosensor for Cu2+ and the study of its behaviour in living cells","volume":"39","author":"Huang","year":"2010","journal-title":"Dalton Trans."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1039\/C0OB00411A","article-title":"Highly sensitive and selective turn-on fluorescent and chromogenic probe for Cu2+ and ClO\u2212 based on a N-picolinyl rhodamine B-hydrazide derivative","volume":"9","author":"Liu","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/chem.200801501","article-title":"Construction of fluorescent probes via protection\/deprotection of functional groups: a ratiometric fluorescent probe for Cu2+","volume":"15","author":"Lin","year":"2009","journal-title":"Chem. Eur. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.talanta.2011.06.057","article-title":"\u201cOff-On\u201d based fluorescent fluorescent probe for Cu2+ in aqueous media and living cells","volume":"85","author":"Yu","year":"2011","journal-title":"Talanta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.tet.2007.11.063","article-title":"FRET-derived ratiometric fluorescence for Cu2+","volume":"64","author":"Kim","year":"2008","journal-title":"Tetrahedron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21375","DOI":"10.3390\/s141121375","article-title":"Synthesis of a Cu2+-selective probe derived from rhodamine and its application in cell imaging","volume":"14","author":"Yu","year":"2014","journal-title":"Sensors"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1016\/j.tetlet.2007.10.109","article-title":"A naphthalimide\u2013calixarene as a two-faced and highly selective fluorescent chemosensor for Cu2+ or F\u2212","volume":"48","author":"Xu","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1021\/ic301872q","article-title":"NIR- and FRET-based sensing of Cu2+ and S2\u2212 in physiological conditions and in live cells","volume":"52","author":"Kar","year":"2013","journal-title":"Inorg. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.dyepig.2009.02.004","article-title":"The synthesis of crown ether-appended dichlorofluoresceins and their selective Cu2+ chemosensing","volume":"82","author":"Kim","year":"2009","journal-title":"Dyes Pigm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1021\/ac051010r","article-title":"Copper ion-selective fluorescent sensor based on the inner filter effect using a spiropyran derivative","volume":"77","author":"Shao","year":"2005","journal-title":"Anal. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/ajoc.201402160","article-title":"Copper(II)-responsive \u201coff-on\u201d chemosensor based on a naphthalimide derivative","volume":"3","author":"Yu","year":"2014","journal-title":"Asian J. Org. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/ol062518z","article-title":"Fluorescence turn on of coumarin derivatives by metal cations: A new signaling mechanism based on C=N isomerization","volume":"9","author":"Wu","year":"2007","journal-title":"Org. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1080\/00032710802237673","article-title":"A coumarin-derived fluorescence chemosensors selective for copper(II)","volume":"41","author":"Sheng","year":"2008","journal-title":"Anal. Lett."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/12\/24146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:11:01Z","timestamp":1760217061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/14\/12\/24146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["s141224146"],"URL":"https:\/\/doi.org\/10.3390\/s141224146","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}