{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:41:29Z","timestamp":1777642889774,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Scientific Equipment Development Project of China","award":["2012YQ030111"],"award-info":[{"award-number":["2012YQ030111"]}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z141109001814078"],"award-info":[{"award-number":["Z141109001814078"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Sulfadimidine (SM2) is a highly toxic and ubiquitous pollutant which requires rapid, sensitive and portable detection method for environmental and food monitoring. Herein, the use for the detection of SM2 of a portable optofluidics-based biosensing platform, which was used for the accurate detection of bisphenol A, atrazine and melamine, is reported for the first time. The proposed compact biosensing system combines the advantages of an evanescent wave immunosensor and microfluidic technology. Through the indirect competitive immunoassay, the detection limit of the proposed optofluidics-based biosensing platform for SM2 reaches 0.05 \u03bcg\u00b7L\u22121 at the concentration of Cy5.5-labeled antibody of 0.1 \u03bcg\u00b7mL\u22121. Linearity is obtained over a dynamic range from 0.17 \u03bcg\u00b7L\u22121 to 10.73 \u03bcg\u00b7L\u22121. The surface of the fiber probe can be regenerated more than 300 times by means of 0.5% sodium dodecyl sulfate solution (pH = 1.9) washes without losing sensitivity. This method, featuring high sensitivity, portability and acceptable reproducibility shows potential in the detection of SM2 in real milk and other dairy products.<\/jats:p>","DOI":"10.3390\/s150408302","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T10:44:31Z","timestamp":1428576271000},"page":"8302-8313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Portable and Reusable Optofluidics-Based Biosensing Platform for Ultrasensitive Detection of Sulfadimidine in Dairy Products"],"prefix":"10.3390","volume":"15","author":[{"given":"Xiu-Juan","family":"Hao","sequence":"first","affiliation":[{"name":"State Key Joint Laboratory of ESPC, School of Environment, Tsinghua University, Beijing 100084, China"},{"name":"Civil Engineering Institute, Inner Mongolia University of Technology, Hohhot 010051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Joint Laboratory of ESPC, School of Environment, Tsinghua University, Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Institute of Food Quality Supervision Inspection and Research, Shijiazhuang 050091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Long","sequence":"additional","affiliation":[{"name":"School of Environment and Natural Resources, Renmin University of China, Beijing 100872, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"Civil Engineering Institute, Inner Mongolia University of Technology, Hohhot 010051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Chang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Joint Laboratory of ESPC, School of Environment, Tsinghua University, Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.talanta.2004.02.038","article-title":"Multiresidue determination of sulfonamides in a variety of biological matrices by supported liquid membrane with high pressure liquid chromatography-electrospray mass spectrometry detection","volume":"64","author":"Msagati","year":"2004","journal-title":"Talanta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8240","DOI":"10.1016\/j.chroma.2009.05.031","article-title":"Simple and sensitive monitoring of sulfonamide veterinary residues in milk by stir bar sorptive extraction based on monolithic material and high performance liquid chromatography analysis","volume":"1216","author":"Huang","year":"2009","journal-title":"J. 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