{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:54:11Z","timestamp":1773158051209,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIPA IT Consilience Creative Program","award":["NIPA-2013-H0203-13-1001"],"award-info":[{"award-number":["NIPA-2013-H0203-13-1001"]}]},{"name":"NRF Engineering Research Center grant","award":["NRF-2011-0030075"],"award-info":[{"award-number":["NRF-2011-0030075"]}]},{"name":"NRF Mid-career Researcher Program","award":["NRF-2012R1A2A2A06047424"],"award-info":[{"award-number":["NRF-2012R1A2A2A06047424"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Optical-resolution photoacoustic microscopy (OR-PAM) is an imaging tool to provide in vivo optically sensitive images in biomedical research. To achieve a small size, fast imaging speed, wide scan range, and high signal-to-noise ratios (SNRs) in a water environment, we introduce a polydimethylsiloxane (PDMS)-based 2-axis scanner for a flexible and waterproof structure. The design, theoretical background, fabrication process and performance of the scanner are explained in details. The designed and fabricated scanner has dimensions of 15 \u00d7 15 \u00d7 15 mm along the X, Y and Z axes, respectively. The characteristics of the scanner are tested under DC and AC conditions. By pairing with electromagnetic forces, the maximum scanning angles in air and water are 18\u00b0 and 13\u00b0 along the X and Y axes, respectively. The measured resonance frequencies in air and water are 60 and 45 Hz along the X axis and 45 and 30 Hz along the Y axis, respectively. Finally,  OR-PAM with high SNRs is demonstrated using the fabricated scanner, and the PA images of micro-patterned samples and microvasculatures of a mouse ear are successfully obtained with high-resolution and wide-field of view. OR-PAM equipped with the 2-axis PDMS based waterproof scanner has lateral and axial resolutions of 3.6 \u03bcm and 26 \u03bcm, respectively. This compact OR-PAM system could potentially and widely be used in preclinical and clinical applications.<\/jats:p>","DOI":"10.3390\/s150509815","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T12:16:51Z","timestamp":1430137011000},"page":"9815-9826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A PDMS-Based 2-Axis Waterproof Scanner for  Photoacoustic Microscopy"],"prefix":"10.3390","volume":"15","author":[{"given":"Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungjin","family":"Park","sequence":"additional","affiliation":[{"name":"School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science  and Technology (POSTECH), Pohang 790-784, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geunbae","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chulhong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea"},{"name":"Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1021\/cr900266s","article-title":"In vivo photoacoustic tomography of chemicals: High-resolution functional and molecular optical imaging at new depths","volume":"110","author":"Kim","year":"2010","journal-title":"Chem. 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