{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:46:23Z","timestamp":1768470383264,"version":"3.49.0"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this study, we developed a reflective localized surface plasmon resonance (LSPR) optical fiber sensor, based on silver nanoparticles (Ag NPs). To enhance the sensitivity of the LSPR optical sensor, two key parameters were optimized, the length of the sensing area and the coating time of the Ag NPs. A sensing length of 1.5 cm and a 1-h coating time proved to be suitable conditions to produce highly sensitive sensors for biosensing. The optimized sensor has a high refractive index sensitivity of 387 nm\/RIU, which is much higher than that of other reported individual silver nanoparticles in solutions. Moreover, the sensor was further modified with antigen to act as a biosensor. Distinctive wavelength shifts were found after each surface modification step. In addition, the reflective LSPR optical fiber sensor has high reproducibility and stability.<\/jats:p>","DOI":"10.3390\/s150612205","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T11:07:05Z","timestamp":1432638425000},"page":"12205-12217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Optimization and Application of Reflective LSPR Optical Fiber Biosensors Based on Silver Nanoparticles"],"prefix":"10.3390","volume":"15","author":[{"given":"Jiangping","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}]},{"given":"Se","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}]},{"given":"Rongxin","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"},{"name":"Collaborative Innovation Center of Chemical Science and Engineering (Tianjin),  Tianjin 300072, China"}]},{"given":"Wei","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"},{"name":"Collaborative Innovation Center of Chemical Science and Engineering (Tianjin),  Tianjin 300072, China"}]},{"given":"Renliang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China"}]},{"given":"Mengfan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}]},{"given":"Libing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}]},{"given":"Zhimin","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10907","DOI":"10.3390\/s111110907","article-title":"Plasmonic nanostructures for nano-scale bio-sensing","volume":"11","author":"Chung","year":"2011","journal-title":"Sensors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1021\/nn203336m","article-title":"Self-assembly of large-scale and ultrathin silver nanoplate films with tunable plasmon resonance properties","volume":"5","author":"Zhang","year":"2011","journal-title":"ACS Nano"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/nl0340475","article-title":"Local refractive index dependence of plasmon resonance spectra from individual nanoparticles","volume":"3","author":"Mock","year":"2003","journal-title":"Nano 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