{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:58:32Z","timestamp":1780995512339,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61271088"],"award-info":[{"award-number":["61271088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61431012"],"award-info":[{"award-number":["61431012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, AuPt bimetallic nanoparticles-graphene nanocomposites were obtained by electrochemical co-reduction of graphene oxide (GO), HAuCl4 and H2PtCl6. The as-prepared AuPt bimetallic nanoparticles-graphene nanocomposites were characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and other electrochemical methods. The morphology and composition of the nanocomposite could be easily controlled by adjusting the HAuCl4\/H2PtCl6 concentration ratio. The electrochemical experiments showed that when the concentration ratio of HAuCl4\/H2PtCl6 was 1:1, the obtained AuPt bimetallic nanoparticles-graphene nanocomposite (denoted as Au1Pt1NPs-GR) possessed the highest electrocatalytic activity toward dopamine (DA).  As such, Au1Pt1NPs-GR nanocomposites were used to detect DA in the presence of ascorbic acid (AA) and uric acid (UA) using the differential pulse voltammetry (DPV) technique and on the modified electrode, there were three separate DPV oxidation peaks with the peak potential separations of 177 mV, 130 mV and 307 mV for DA and AA, DA and UA, AA and UA, respectively. The linear range of the constructed DA sensor was from 1.6 \u03bcM to 39.7 \u03bcM with a detection limit of 0.1 \u03bcM (S\/N = 3). The obtained DA sensor with good stability, high reproducibility and excellent selectivity made it possible to detect DA in human urine samples.<\/jats:p>","DOI":"10.3390\/s150716614","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T02:02:23Z","timestamp":1436493743000},"page":"16614-16631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Electrochemical Co-Reduction Synthesis of AuPt Bimetallic Nanoparticles-Graphene Nanocomposites for Selective Detection of Dopamine in the Presence of Ascorbic Acid and Uric Acid"],"prefix":"10.3390","volume":"15","author":[{"given":"Zongya","family":"Zhao","sequence":"first","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University,  Xi'an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University,  Xi'an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University,  Xi'an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University,  Xi'an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University,  Xi'an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.talanta.2007.05.049","article-title":"Preparation and characterization of PtAu hybrid film modified electrodes and their use in simultaneous determination of dopamine, ascorbic acid and uric acid","volume":"74","author":"Thiagarajan","year":"2007","journal-title":"Talanta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s11426-012-4827-z","article-title":"Electrooxidation of hydroquinone on simply prepared Au-Pt bimetallic nanoparticles","volume":"56","author":"Etesami","year":"2013","journal-title":"Sci. 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