{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:12:30Z","timestamp":1772611950671,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A high-sensitivity Mach-Zehnder interferometer (MZI) biochemical sensing platform based on Silicon-in-insulator (SOI) rib waveguide with large cross section is proposed in this paper. Based on the analyses of the evanescent field intensity, the mode polarization and cross section dimensions of the SOI rib waveguide are optimized through finite difference method (FDM) simulation. To realize high-resolution MZI read-out configuration based on the SOI rib waveguide, medium-filled trenches are employed and their performances are simulated through two-dimensional finite-difference-time domain (2D-FDTD) method. With the fundamental EH-polarized mode of the SOI rib waveguide with a total rib height of 10 \u03bcm, an outside rib height of 5 \u03bcm and a rib width of 2.5 \u03bcm at the operating wavelength of 1550 nm, when the length of the sensitive window in the MZI configuration is 10 mm, a homogeneous sensitivity of 7296.6%\/refractive index unit (RIU) is obtained. Supposing the resolutions of the photoelectric detectors connected to the output ports are 0.2%, the MZI sensor can achieve a detection limit of 2.74 \u00d7 10\u22126 RIU. Due to high coupling efficiency of SOI rib waveguide with large cross section with standard single-mode glass optical fiber, the proposed MZI sensing platform can be conveniently integrated with optical fiber communication systems and (opto-) electronic systems, and therefore has the potential to realize remote sensing, in situ real-time detecting, and possible applications in the internet of things.<\/jats:p>","DOI":"10.3390\/s150921500","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T10:55:58Z","timestamp":1441104958000},"page":"21500-21517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Mach-Zehnder Interferometer Biochemical Sensor Based on Silicon-on-Insulator Rib Waveguide with Large Cross Section"],"prefix":"10.3390","volume":"15","author":[{"given":"Dengpeng","family":"Yuan","sequence":"first","affiliation":[{"name":"Graduate School at Shenzhen, Tsinghua University, J209A, Tsinghua Campus,  University Town of Shenzhen, Shenzhen 518055, China"},{"name":"Institute of Material, China Academy of Engineering Physics, Jiangyou 621908, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-8653","authenticated-orcid":false,"given":"Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Graduate School at Shenzhen, Tsinghua University, J209A, Tsinghua Campus,  University Town of Shenzhen, Shenzhen 518055, China"}]},{"given":"Yujin","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School at Shenzhen, Tsinghua University, J209A, Tsinghua Campus,  University Town of Shenzhen, Shenzhen 518055, China"}]},{"given":"Tianjian","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School at Shenzhen, Tsinghua University, J209A, Tsinghua Campus,  University Town of Shenzhen, Shenzhen 518055, China"}]}],"member":"1968","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.aca.2006.04.045","article-title":"A Mach-Zehnder interferometer based on silicon oxides for biosensor applications","volume":"573\u2013574","author":"Hong","year":"2006","journal-title":"Anal. 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