{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:22:08Z","timestamp":1773350528912,"version":"3.50.1"},"reference-count":18,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>It is possible to evaluate the taste of foods or medicines using a taste sensor. The taste sensor converts information on taste into an electrical signal using several lipid\/polymer membranes. A lipid\/polymer membrane for bitterness sensing can evaluate aftertaste after immersion in monosodium glutamate (MSG), which is called \u201cpreconditioning\u201d. However, we have not yet analyzed the change in the surface structure of the membrane as a result of preconditioning. Thus, we analyzed the change in the surface by performing contact angle and surface zeta potential measurements, Fourier transform infrared spectroscopy (FTIR), X-ray photon spectroscopy (XPS) and gas cluster ion beam time-of-flight secondary ion mass spectrometry (GCIB-TOF-SIMS). After preconditioning, the concentrations of MSG and tetradodecylammonium bromide (TDAB), contained in the lipid membrane were found to be higher in the surface region than in the bulk region. The effect of preconditioning was revealed by the above analysis methods.<\/jats:p>","DOI":"10.3390\/s150922439","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T11:59:54Z","timestamp":1441713594000},"page":"22439-22450","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Analysis of a Lipid\/Polymer Membrane for Bitterness Sensing with a Preconditioning Process"],"prefix":"10.3390","volume":"15","author":[{"given":"Rui","family":"Yatabe","sequence":"first","affiliation":[{"name":"Research and Development Center for Taste and Odor Sensing, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpei","family":"Noda","sequence":"additional","affiliation":[{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tahara","sequence":"additional","affiliation":[{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Naito","sequence":"additional","affiliation":[{"name":"Intelligent Sensor Technology, Inc., 5-1-1 Onna, Atsugi-shi, Kanagawa 243-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Ikezaki","sequence":"additional","affiliation":[{"name":"Intelligent Sensor Technology, Inc., 5-1-1 Onna, Atsugi-shi, Kanagawa 243-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Toko","sequence":"additional","affiliation":[{"name":"Research and Development Center for Taste and Odor Sensing, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan"},{"name":"Graduate School of Information Science and Electrical Engineering, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"ref_1","unstructured":"Toko, K. (2013). Biochemical Sensors: Mimicking Gustatory and Olfactory Senses, Pan Stanford Publishing."},{"key":"ref_2","first-page":"107","article-title":"Taste Sensor","volume":"Volume 10","author":"Habara","year":"2006","journal-title":"Encyclopedia of Sensors"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.drudis.2007.01.010","article-title":"The Latest Trends in the Taste Assessment of Pharmaceuticals","volume":"12","author":"Anand","year":"2007","journal-title":"Drug Discov. Today"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1021\/ac086073z","article-title":"Smart Taste Sensors","volume":"80","author":"Citterio","year":"2008","journal-title":"Anal. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00604-007-0929-2","article-title":"Voltammetric Electronic Tongues\u2014Basic Principles and Applications","volume":"163","author":"Winquist","year":"2008","journal-title":"Microchimica. Acta."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/tee.20469","article-title":"Development of an Artificial Lipid-Based Membrane Sensor with High Selectivity and Sensitivity to the Bitterness of Drugs and with High Correlation with Sensory Score","volume":"4","author":"Kobayashi","year":"2009","journal-title":"IEEJ Trans. Electr. Electron. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1248\/cpb.58.1009","article-title":"A New Method for Evaluating the Bitterness of Medicines in Development using a Taste Sensor and a Disintegration Testing Apparatus","volume":"58","author":"Harada","year":"2010","journal-title":"Chem. Pharm. Bull."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.3390\/s100403411","article-title":"Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores","volume":"10","author":"Kobayashi","year":"2010","journal-title":"Sensors"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1039\/c0an00292e","article-title":"Recent Advances in Electronic Tongues","volume":"135","author":"Riul","year":"2010","journal-title":"Analyst"},{"key":"ref_10","first-page":"501","article-title":"Evaluation of the Taste of Tea with Different Degrees of Fermentation using a Taste Sensing System","volume":"23","author":"Uchiyama","year":"2011","journal-title":"Sens. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpba.2011.02.002","article-title":"A Comparative Study on Two Electronic Tongues for Pharmaceutical Formulation Development","volume":"55","author":"Woertz","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijpharm.2010.11.028","article-title":"Taste Sensing Systems (Electronic Tongues) for Pharmaceutical Applications","volume":"417","author":"Woertz","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/486S18a","article-title":"Technology: The Taste of Things to Come","volume":"486","author":"Savage","year":"2012","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1109\/JSEN.2013.2263125","article-title":"Electronic Tongues-a Review","volume":"13","author":"Tahara","year":"2013","journal-title":"IEEE Sens. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1166\/sl.2014.3182","article-title":"Examination of Amount of Astringent Substances Adsorbed Onto lipid\/polymer Membrane used in Taste Sensor","volume":"12","author":"Hara","year":"2014","journal-title":"Sens. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16274","DOI":"10.3390\/s140916274","article-title":"Relationship between the Amount of Bitter Substances Adsorbed Onto Lipid\/polymer Membrane and the Electric Response of Taste Sensors","volume":"14","author":"Toko","year":"2014","journal-title":"Sensors"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.3390\/s150306241","article-title":"Study of the Relationship between Taste Sensor Response and the Amount of Epigallocatechin Gallate Adsorbed Onto a Lipid-Polymer Membrane","volume":"15","author":"Harada","year":"2015","journal-title":"Sensors"},{"key":"ref_18","unstructured":"Insent, Inc. (2007). Highly Durable and Rapidly Measurable Taste Sensor for Quality Control of Products Using Artificial Lipid\/polymer Membrane, Report of Risk-taking Fund for Technology Development, Japan Science and Technology Agency."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/15\/9\/22439\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:48:00Z","timestamp":1760215680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/15\/9\/22439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,4]]},"references-count":18,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9]]}},"alternative-id":["s150922439"],"URL":"https:\/\/doi.org\/10.3390\/s150922439","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,4]]}}}