{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:22:08Z","timestamp":1775384528048,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng\/mL to 10 ng\/mL. The detection limit reaches 48.7 pg\/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.<\/jats:p>","DOI":"10.3390\/s151229877","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T10:09:11Z","timestamp":1450174151000},"page":"31558-31565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers"],"prefix":"10.3390","volume":"15","author":[{"given":"Yangqing","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Chang","sequence":"additional","affiliation":[{"name":"CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longhua","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Fei","family":"Dong","sequence":"additional","affiliation":[{"name":"CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Jun","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.talanta.2007.05.008","article-title":"A competitive immunochromatographic assay for testosterone based on electrochemical detection","volume":"73","author":"Inoue","year":"2007","journal-title":"Talanta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3390\/s130202148","article-title":"In vitro androgen bioassays as a detection method for designer androgens","volume":"13","author":"Cooper","year":"2013","journal-title":"Sensors"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1007\/s00421-011-2246-z","article-title":"Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training","volume":"112","author":"West","year":"2012","journal-title":"Eur. 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