{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:18:45Z","timestamp":1760242725660,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21545012","21175010","21275017"],"award-info":[{"award-number":["21545012","21175010","21275017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Herein we report for the first time fabrication of reverse bumpy ball (RBB)-type-nanoreactor-based flexible peroxidase-mimic membrane reactors (MRs). The RBB-type nanoreactors with gold nanoparticles embedded in the inner walls of carbon shells were loaded on nylon membranes through a facile filtration approach. The as-prepared flexible catalytic membrane was studied as a peroxidase-mimic MR. It was found that the obtained peroxidase-mimic MR could exhibit several advantages over natural enzymes, such as facile and good recyclability, long-term stability and easy storage. Moreover, the RBB NS-modified nylon MRs as a peroxidase mimic provide a useful colorimetric assay for H2O2.<\/jats:p>","DOI":"10.3390\/s16040465","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T10:31:20Z","timestamp":1459506680000},"page":"465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reverse-Bumpy-Ball-Type-Nanoreactor-Loaded Nylon Membranes as Peroxidase-Mimic Membrane Reactors for a Colorimetric Assay for H2O2"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-0767","authenticated-orcid":false,"given":"Ying","family":"Tong","sequence":"first","affiliation":[{"name":"Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Jiao","sequence":"additional","affiliation":[{"name":"Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hankun","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-1552","authenticated-orcid":false,"given":"Lei","family":"Su","sequence":"additional","affiliation":[{"name":"Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueji","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12196","DOI":"10.1002\/chem.201301802","article-title":"Hollow-Shelled Nanoreactors Endowed with High Catalytic Activity","volume":"19","author":"Vaz","year":"2013","journal-title":"Chem. Eur. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1021\/acs.langmuir.5b00098","article-title":"Enhancing the Exploitation of Functional Nanomaterials through Spatial Confinement: The Case of Inorganic Submicrometer Capsules","volume":"31","author":"Vaz","year":"2015","journal-title":"Langmuir"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1002\/anie.201105283","article-title":"Highly Active Nanoreactors: Nanomaterial Encapsulation Based on Confined Catalysis","volume":"51","author":"Salgueirino","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1039\/c0cc01786h","article-title":"Pd nanoparticles in silica hollow spheres with mesoporous walls: a nanoreactor with extremely high activity","volume":"46","author":"Chen","year":"2010","journal-title":"Chem. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/ja511498s","article-title":"Toward Fundamentals of Confined Catalysis in Carbon Nanotubes","volume":"137","author":"Xiao","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1021\/ja8088444","article-title":"Design of SERS-Encoded, Submicron, Hollow Particles Through Confined Growth of Encapsulated Metal Nanoparticles","volume":"131","author":"Exner","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcis.2012.12.010","article-title":"Polymer shell as a protective layer for the sandwiched gold nanoparticles and their recyclable catalytic property","volume":"395","author":"Liu","year":"2013","journal-title":"J. Colloid Interface Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhang, Z.Y., Xiao, F., Xi, J.B., Sun, T., Xiao, S., Wang, H.R., Wang, S., and Liu, Y.Q. (2014). Encapsulating Pd nanoparticles in double-shelled graphene@ carbon hollow spheres for excellent chemical catalytic property. Sci. Rep. UK.","DOI":"10.1038\/srep04053"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"23230","DOI":"10.1039\/C5TA05092H","article-title":"Polymer-templated synthesis of hollow Pd-CeO2 nanocomposite spheres and their catalytic activity and thermal stability","volume":"3","author":"Du","year":"2015","journal-title":"J. Mater. Chem. A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11245","DOI":"10.1039\/c2jm31138k","article-title":"A general and feasible method for the fabrication of functional nanoparticles in mesoporous silica hollow composite spheres","volume":"22","author":"Yin","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15864","DOI":"10.1021\/ja4069134","article-title":"Pt@CeO2 Multicore@Shell Self-Assembled Nanospheres: Clean Synthesis, Structure Optimization, and Catalytic Applications","volume":"135","author":"Wang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10615","DOI":"10.1039\/c0jm02647f","article-title":"Hollow silica nanosphere having functionalized interior surface with thin manganese oxide layer: nanoreactor framework for size-selective Lewis acid catalysis","volume":"20","author":"Anisur","year":"2010","journal-title":"J. Mater. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1039\/C4NR06366J","article-title":"Fe\/N\/C hollow nanospheres by Fe(III)-dopamine complexation-assisted one-pot doping as nonprecious-metal electrocatalysts for oxygen reduction","volume":"7","author":"Zhou","year":"2015","journal-title":"Nanoscale"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1039\/c1cc13717d","article-title":"Rattle-type microspheres as a support of tiny gold nanoparticles for highly efficient catalysis","volume":"47","author":"Liu","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jcis.2014.05.005","article-title":"Synthesis of mesoporous silica hollow nanospheres with multiple gold cores and catalytic activity","volume":"429","author":"Chen","year":"2014","journal-title":"J. Colloid Interface Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14378","DOI":"10.1002\/chem.201001679","article-title":"A Highly Efficient and Extensively Reusable \u201cDip Catalyst\u201d Based on a Silver-Nanoparticle-Embedded Polymer Thin Film","volume":"16","author":"Hariprasad","year":"2010","journal-title":"Chem. Eur. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1039\/C5CC00798D","article-title":"Preparation of catalytic films of the Au nanoparticle\u2013carbon composite tubular arrays","volume":"51","author":"Gong","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1021\/cs300158g","article-title":"Palladium Nanoparticle-Embedded Polymer Thin Film \u201cDip Catalyst\u201d for Suzuki-Miyaura Reaction","volume":"2","author":"Hariprasad","year":"2012","journal-title":"ACS Catal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"13446","DOI":"10.1039\/C4RA01104J","article-title":"Palladium nanoparticles supported in a polymeric membrane: an efficient phosphine-free \u201cgreen\u201d catalyst for Suzuki\u2013Miyaura reactions in water","volume":"4","author":"Faria","year":"2014","journal-title":"RSC Adv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10504","DOI":"10.1039\/C5TA00409H","article-title":"3D graphene\/nylon rope as a skeleton for noble metal nanocatalysts for highly efficient heterogeneous continuous-flow reactions","volume":"3","author":"Zhang","year":"2015","journal-title":"J. Mater. Chem. A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1039\/c0cc04734a","article-title":"Contra-diffusion synthesis of ZIF-8 films on a polymer substrate","volume":"47","author":"Yao","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1126\/science.1242196","article-title":"Organotextile Catalysis","volume":"341","author":"Lee","year":"2013","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1002\/ange.201102070","article-title":"Dopamine as a Carbon Source: The Controlled Synthesis of Hollow Carbon Spheres and Yolk-Structured Carbon Nanocomposites","volume":"30","author":"Liu","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12174","DOI":"10.1039\/C5CC02559A","article-title":"Nanocomposite hydrogels based on liquid crystalline brush-like block copolymer\u2014Au nanorods and their application in H2O2 detection","volume":"51","author":"Nguyen","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1039\/B609137G","article-title":"Carbon nanotube\/polysulfone composite screen-printed electrochemical enzyme biosensors","volume":"132","author":"Pumera","year":"2007","journal-title":"Analyst"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/ac500595v","article-title":"Transition Metal Hexacyanoferrates in Electrocatalysis of H2O2 Reduction: An Exclusive Property of Prussian Blue","volume":"86","author":"Sitnikova","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1021\/jp0107964","article-title":"Wet Chemical Synthesis of High Aspect Ratio Cylindrical Gold Nanorods","volume":"105","author":"Jana","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1016\/j.electacta.2011.02.028","article-title":"Different synthesis methods allow to tune the permeability and permselectivity of dopamine-melanin films to electrochemical probes","volume":"56","author":"Bernsmann","year":"2011","journal-title":"Electrochim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.snb.2014.12.107","article-title":"Electrochemical glucose biosensor with improved performance based on the use of glucose oxidase and Prussian Blue incorporated into a thin film of self-polymerized dopamine","volume":"210","author":"Lin","year":"2015","journal-title":"Sens. Actuators B Chem."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/16\/4\/465\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:21:39Z","timestamp":1760210499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/16\/4\/465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,1]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4]]}},"alternative-id":["s16040465"],"URL":"https:\/\/doi.org\/10.3390\/s16040465","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2016,4,1]]}}}