{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:34:55Z","timestamp":1778826895079,"version":"3.51.4"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1A5A1037656"],"award-info":[{"award-number":["2015R1A5A1037656"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>As surface plasmon resonance (SPR)-based biosensors are well translated into biological, chemical, environmental, and clinical fields, it is critical to further realize stable and sustainable systems, avoiding oxidation susceptibility of metal films\u2014in particular, silver substrates. We report an enhanced SPR detection performance by incorporating a TiO2 layer on top of a thin silver film. A uniform TiO2 film fabricated by electron beam evaporation at room temperature is an effective alternative in bypassing oxidation of a silver film. Based on our finding that the sensor sensitivity is strongly correlated with the slope of dispersion curves, SPR sensing results obtained by parylene film deposition shows that TiO2\/silver hybrid substrates provide notable sensitivity improvement compared to a conventional bare silver film, which confirms the possibility of engineering the dispersion characteristic according to the incidence wavelength. The reported SPR structures with TiO2 films enhance the sensitivity significantly in water and air environments and its overall qualitative trend in sensitivity improvement is consistent with numerical simulations. Thus, we expect that our approach can extend the applicability of TiO2-mediated SPR biosensors to highly sensitive detection for biomolecular binding events of low concentrations, while serving a practical and reliable biosensing platform.<\/jats:p>","DOI":"10.3390\/s16091442","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T09:59:46Z","timestamp":1473242386000},"page":"1442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dispersion Curve Engineering of TiO2\/Silver Hybrid Substrates for Enhanced Surface Plasmon Resonance Detection"],"prefix":"10.3390","volume":"16","author":[{"given":"Sherif","family":"El-Gohary","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munsik","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Kyung Hee University, Yongin 17104, Korea"},{"name":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0925-4005(98)00321-9","article-title":"Surface Plasmon Resonance Sensors: Review","volume":"54","author":"Homola","year":"1999","journal-title":"Sens. Actuators B Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1364\/OL.33.002539","article-title":"Sensitivity Enhancement of Guide-Wave Surface-Plasmon Resonane Sensors","volume":"33","author":"Lahav","year":"2008","journal-title":"Opt. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pquantelec.2013.02.001","article-title":"Label-Free Optical Resonant Sensors for Biochemical Applications","volume":"37","author":"Ciminelli","year":"2013","journal-title":"Prog. Quantum Electron."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jbio.201200015","article-title":"Surface Plasmon Resonance Based Biosensor Technique: A Review","volume":"5","author":"Guo","year":"2012","journal-title":"J. Biophotonics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0958-1669(99)00054-3","article-title":"Advances in Surface Plasmon Resonance Biosensor Analysis","volume":"11","author":"Rich","year":"2000","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/meth.1999.0925","article-title":"Application of Surface Plasmon Resonance toward Studies of Low-Molecular-Weight Antigen-Antibody Binding Interactions","volume":"20","author":"Adamczyk","year":"2000","journal-title":"Methods"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1155\/2003\/372913","article-title":"Surface Plasmon Resonance: Principles, Methods and Applications in Biomedical Sciences","volume":"17","author":"Englebienne","year":"2003","journal-title":"Spectroscopy"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/lpor.201000009","article-title":"Sensitivity Enhancement Methods for Surface Plasmon Sensors","volume":"5","author":"Shalabney","year":"2011","journal-title":"Lasers Photonics Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/cr068107d","article-title":"Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species","volume":"108","author":"Homola","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0925-4005(97)80052-4","article-title":"High Sensitivity Surface Plasmon Resonance Sensor Based on Phase Detection","volume":"35","author":"Nelson","year":"1996","journal-title":"Sens. Actuators B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0003-2670(00)81337-9","article-title":"Surface Plasmon Resonance Immunosensors: Sensitivity Considerations","volume":"213","author":"Kooyman","year":"1988","journal-title":"Anal. Chim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/s20200062","article-title":"Bimetallic Layers Increase Sensitivity of Affinity Sensors Based on Surface Plasmon Resonance","volume":"2","author":"Zynio","year":"2002","journal-title":"Sensors"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1364\/AO.50.000387","article-title":"Bimetallic Chips for a Surface Plasmon Resonance Instrument","volume":"50","author":"Chen","year":"2011","journal-title":"Appl. Opt."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1364\/OE.19.000458","article-title":"Graphene-on-Silver Substrates for Sensitive Surface Plasmon Resonance Imaging Biosensors","volume":"19","author":"Choi","year":"2011","journal-title":"Opt. Express"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15813","DOI":"10.1021\/jp8049137","article-title":"Surface Plasmon Resonance Investigation of Silver and Gold Films Coated with Thin Indium Tin Oxide Layers: Influence on Stability and Sensitivity","volume":"112","author":"Szunerits","year":"2008","journal-title":"J. Phys. Chem. C"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1364\/OL.34.002867","article-title":"Plasmonic Phenomena in Indium Tin Oxide and ITO-Au Hybrid Films","volume":"34","author":"Franzen","year":"2009","journal-title":"Opt. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"031501","DOI":"10.1117\/1.3079803","article-title":"Surface Plasmon Sensor with Enhanced Sensitivity Using Top Nano Dielectric Layer","volume":"3","author":"Lahav","year":"2009","journal-title":"J. Nanophotonics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1364\/OL.37.001175","article-title":"Figure of Merit Enhancement of Surface Plasmon Resonance Sensors in the Spectral Interrogation","volume":"37","author":"Shalabney","year":"2012","journal-title":"Opt. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/revac.2011.120","article-title":"Dielectric Coated Plasmonic Interfaces: Their Interest for Sensitive Sensing of Analyte-Ligand Interactions","volume":"31","author":"Szunerits","year":"2012","journal-title":"Rev. Anal. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.apsusc.2016.03.123","article-title":"A Stable and High Resolution Optical Waveguide Biosensor Based on Dense TiO2\/Ag Multilayer Film","volume":"377","author":"Jin","year":"2016","journal-title":"App. Surf. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.optcom.2016.03.011","article-title":"Dispersion Curve-Based Sensitivity Engineering for Enhanced Surface Plasmon Resonance Detection","volume":"370","author":"Eom","year":"2016","journal-title":"Opt. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"073799","DOI":"10.1117\/1.JNP.7.073799","article-title":"Optical Determination of Thick Graphene Layer Number Based on Surface Plasmon Resonance","volume":"7","author":"Kim","year":"2013","journal-title":"J. Nanophotonics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1364\/JOSA.41.000416","article-title":"Refractive indices of rutile and sphalerite","volume":"41","author":"Devore","year":"1951","journal-title":"J. Opt. Soc. Am."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1364\/AO.37.005271","article-title":"Optical Properties of Metallic Films for Vertical-Cavity Optoelectronic Devices","volume":"37","author":"Rakic","year":"1998","journal-title":"Appl. Opt."},{"key":"ref_25","first-page":"503749","article-title":"Study on Dielectric Function Models for Surface Plasmon Resonance Structure","volume":"1","author":"Jahanshahi","year":"2014","journal-title":"Sci. World J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"083113","DOI":"10.1063\/1.4745651","article-title":"Ultra-Thin Titanium Oxide","volume":"101","author":"Jirauschek","year":"2012","journal-title":"Appl. Phys. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.proche.2009.07.258","article-title":"Application of a Functionalized Parylene Film as a Linker Layer of SPR Biosensor","volume":"1","author":"Jeon","year":"2009","journal-title":"Procedia Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bios.2014.01.035","article-title":"Development of SPR Biosensor for the Detection of Human Hepatitis B Virus Using Plasma-Treated Parylene-N Film","volume":"56","author":"Choi","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6122","DOI":"10.1039\/c3cp50758k","article-title":"Measurement of the Localized Plasmon Penetration Depth for Gold Nanoparticles Using a Non-Invasive Bio-Stacking Method","volume":"15","author":"Read","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1023\/B:OXID.0000016275.96500.24","article-title":"Oxidation of Silver by Atomic Oxygen","volume":"61","author":"Zheludkevich","year":"2004","journal-title":"Oxid. Met."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1364\/JOSAA.27.002229","article-title":"Investigation on an Application of Silver Substrates for Sensitive Surface Plasmon Resonance Imaging Detection","volume":"27","author":"Choi","year":"2010","journal-title":"J. Opt. Soc. Am. A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1201045","article-title":"Surface-Plasmon Holography with White-Light Illumination","volume":"332","author":"Ozaki","year":"2011","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1364\/AO.50.004982","article-title":"Correlation Analysis between Plasmon Field Distribution and Sensitivity Enhancement in Reflection- and Transmission-Type Localized Surface Plasmon Resonance Biosensors","volume":"50","author":"Kim","year":"2011","journal-title":"Appl. Opt."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e16017","DOI":"10.1038\/lsa.2016.17","article-title":"Energy Transfer in Plasmonic Photocatalytic Composites","volume":"5","author":"Ma","year":"2016","journal-title":"Light"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/16\/9\/1442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:30:17Z","timestamp":1760211017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/16\/9\/1442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,7]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9]]}},"alternative-id":["s16091442"],"URL":"https:\/\/doi.org\/10.3390\/s16091442","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,7]]}}}