{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:10:32Z","timestamp":1773040232238,"version":"3.50.1"},"reference-count":84,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 61271088"],"award-info":[{"award-number":["Grant No. 61271088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No. 61431012"],"award-info":[{"award-number":["Grant No. 61431012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In order to reduce the impedance and improve in vivo neural recording performance of our developed Michigan type silicon electrodes, rough-surfaced AuPt alloy nanoparticles with nanoporosity were deposited on gold microelectrode sites through electro-co-deposition of Au-Pt-Cu alloy nanoparticles, followed by chemical dealloying Cu. The AuPt alloy nanoparticles modified gold microelectrode sites were characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and in vivo neural recording experiment. The SEM images showed that the prepared AuPt alloy nanoparticles exhibited cauliflower-like shapes and possessed very rough surfaces with many different sizes of pores. Average impedance of rough-surfaced AuPt alloy nanoparticles modified sites was 0.23 M\u03a9 at 1 kHz, which was only 4.7% of that of bare gold microelectrode sites (4.9 M\u03a9), and corresponding in vitro background noise in the range of 1 Hz to 7500 Hz decreased to 7.5     \u03bc  V rms      from 34.1     \u03bc  V rms      at bare gold microelectrode sites. Spontaneous spike signal recording was used to evaluate in vivo neural recording performance of modified microelectrode sites, and results showed that rough-surfaced AuPt alloy nanoparticles modified microelectrode sites exhibited higher average spike signal-to-noise ratio (SNR) of 4.8 in lateral globus pallidus (GPe) due to lower background noise compared to control microelectrodes. Electro-co-deposition of Au-Pt-Cu alloy nanoparticles combined with chemical dealloying Cu was a convenient way for increasing the effective surface area of microelectrode sites, which could reduce electrode impedance and improve the quality of in vivo spike signal recording.<\/jats:p>","DOI":"10.3390\/s16111851","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T10:58:04Z","timestamp":1478170684000},"page":"1851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["In Vivo Neural Recording and Electrochemical Performance of Microelectrode Arrays Modified by Rough-Surfaced AuPt Alloy Nanoparticles with Nanoporosity"],"prefix":"10.3390","volume":"16","author":[{"given":"Zongya","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi\u2019an Jiaotong University Branch, Xi\u2019an 710049, China"}]},{"given":"Ruxue","family":"Gong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi\u2019an Jiaotong University Branch, Xi\u2019an 710049, China"}]},{"given":"Liang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi\u2019an Jiaotong University Branch, Xi\u2019an 710049, China"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"},{"name":"National Engineering Research Center of Health Care and Medical Devices, Xi\u2019an Jiaotong University Branch, Xi\u2019an 710049, China"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.1523\/JNEUROSCI.5459-09.2010","article-title":"Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in parkinson\u2019s disease","volume":"30","author":"Alegre","year":"2010","journal-title":"J. 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