{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:27:03Z","timestamp":1776284823913,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ational Natural Science Foundation of China","award":["21403039"],"award-info":[{"award-number":["21403039"]}]},{"name":"ational Natural Science Foundation of China","award":["21563006"],"award-info":[{"award-number":["21563006"]}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2015GXNSFAA139033"],"award-info":[{"award-number":["2015GXNSFAA139033"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Project of Guangxi Graduate Education","award":["YCSZ2015187"],"award-info":[{"award-number":["YCSZ2015187"]}]},{"name":"Guangxi Colleges and Universities Key Laboratory of Synthetic and Natural Functional Molecular Chemistry, Guangxi Teachers Education University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Based on N-doped carbon dots\/\u03b2-cyclodextrin nanocomposites modified glassy carbon electrodes (N-CDs\/\u03b2-CD\/GCE), an effective electrochemical sensor for enantioselective recognition of tryptophan (Trp) enantiomers was developed by differential pulse voltammograms (DPVs). Fluorescent N-CDs were synthesized through a hydrothermal method and characterized by spectroscopic approaches. The N-CDs\/\u03b2-CD nanocomposites were efficiently electrodeposited on the surface of GCE through C\u2013N bond formation between N-CDs and electrode. The obtained N-CDs\/\u03b2-CD\/GCE was characterized by multispectroscopic and electrochemical methods. Such N-CDs\/\u03b2-CD\/GCE generated a significantly lower Ip and more negative Ep in the presence of l-Trp in DPVs, which was used for the enantioselective recognition of Trp enantiomers. The N-CDs\/\u03b2-CD nanocomposites showed different binding constants for tryptophan enantiomers, and they further selectively bonded with l-Trp to form inclusion complexes. This N-CDs\/\u03b2-CD\/GCE combined advantages of N-CDs with strong C\u2013N binding ability and \u03b2-CD with specific recognition of Trp enantiomers to fabricate a novel sensing platform for enantioselective recognition of Trp enantiomers. This strategy provided the possibility of using a nanostructured sensor to discriminate the chiral molecules in bio-electroanalytical applications.<\/jats:p>","DOI":"10.3390\/s16111874","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T10:09:39Z","timestamp":1478686179000},"page":"1874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Novel N-Doped Carbon Dots\/\u03b2-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers"],"prefix":"10.3390","volume":"16","author":[{"given":"Qi","family":"Xiao","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China"}]},{"given":"Shuangyan","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China"}]},{"given":"Chusheng","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China"}]},{"given":"Wei","family":"Su","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23715","DOI":"10.1038\/srep23715","article-title":"Applicability of the Rayleigh equation for enantioselective metabolism of chiral xenobiotics by microsomes, hepatocytes and in-vivo retention in rabbit tissues","volume":"6","author":"Jammer","year":"2016","journal-title":"Sci. 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