{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:53:42Z","timestamp":1773287622906,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005073","name":"Agency for Defense Development","doi-asserted-by":"publisher","award":["UD160027ID"],"award-info":[{"award-number":["UD160027ID"]}],"id":[{"id":"10.13039\/501100005073","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Science, and Technology","award":["2012-0008611"],"award-info":[{"award-number":["2012-0008611"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transistors; it has the functions of detecting light, generating a stimulation signal in proportion to the light intensity, and transmitting the signal to a micro electrode. To show the applicability of the proposed neural stimulation device as a high-resolution retinal prosthesis system, a high-density neural stimulation device with a unit cell size of 110 \u00d7 110 \u03bc m and a resolution of 32 \u00d7 32 was fabricated on a flexible film with a thickness of approximately 50 \u03bcm. Its effectiveness as a retinal stimulation device was then evaluated using a unit cell in an in vitro animal experiment involving the retinal tissue of retinal Degeneration 1 (rd1) mice. Experiments wherein stimulation pulses were applied to the retinal tissues successfully demonstrate that the number of spikes in neural response signals increases in proportion to light intensity.<\/jats:p>","DOI":"10.3390\/s16122035","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T10:36:37Z","timestamp":1480674997000},"page":"2035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate"],"prefix":"10.3390","volume":"16","author":[{"given":"Suk","family":"Jung","sequence":"first","affiliation":[{"name":"ISRC\/ASRI, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea"},{"name":"Human Care System Research Center, Convergence System R&amp;D Division, Korea Electronics Technology Institute, 25 Saenari-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13509, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-6837","authenticated-orcid":false,"given":"Jong","family":"Shin","sequence":"additional","affiliation":[{"name":"ISRC\/ASRI, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea"}]},{"given":"Kilwha","family":"Pi","sequence":"additional","affiliation":[{"name":"ISRC\/ASRI, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea"}]},{"given":"Yong","family":"Goo","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, Chungbuk 28644, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-5803","authenticated-orcid":false,"given":"Dong-il","family":"Cho","sequence":"additional","affiliation":[{"name":"ISRC\/ASRI, Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.22089","article-title":"A phase I trial of deep brain stimulation of memory circuits in Alzheimer\u2019s disease","volume":"68","author":"Laxton","year":"2010","journal-title":"Ann. 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