{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:04:07Z","timestamp":1775901847011,"version":"3.50.1"},"reference-count":99,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T00:00:00Z","timestamp":1482019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Various methodologies have been reported in the literature for the qualitative and quantitative monitoring of mycotoxins in food and feed samples. Based on their enhanced specificity, selectivity and versatility, bio-affinity assays have inspired many researchers to develop sensors by exploring bio-recognition phenomena. However, a significant problem in the fabrication of these devices is that most of the biomolecules do not generate an easily measurable signal upon binding to the target analytes, and signal-generating labels are required to perform the measurements. In this context, aptamers have been emerged as a potential and attractive bio-recognition element to design label-free aptasensors for various target analytes. Contrary to other bioreceptor-based approaches, the aptamer-based assays rely on antigen binding-induced conformational changes or oligomerization states rather than binding-assisted changes in adsorbed mass or charge. This review will focus on current designs in label-free conformational switchable design strategies, with a particular focus on applications in the detection of mycotoxins.<\/jats:p>","DOI":"10.3390\/s16122178","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T04:09:09Z","timestamp":1482466149000},"page":"2178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Label-Free Aptasensors for the Detection of Mycotoxins"],"prefix":"10.3390","volume":"16","author":[{"given":"Amina","family":"Rhouati","sequence":"first","affiliation":[{"name":"BAE Laboratory, Universit\u00e9 de Perpignan Via Domitia, 52 Avenue Paul Alduy, Perpignan 66860, France"},{"name":"Ecole Nationale Sup\u00e9rieure de Biotechnologie, Constantine 25100, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaelle","family":"Catanante","sequence":"additional","affiliation":[{"name":"BAE Laboratory, Universit\u00e9 de Perpignan Via Domitia, 52 Avenue Paul Alduy, Perpignan 66860, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilvanda","family":"Nunes","sequence":"additional","affiliation":[{"name":"Technological Chemistry Department, Federal University of Maranh\u00e3o, CCET\/UFMA, Av. Portugueses, Cidade Universit\u00e1ria do Canga, 65080-040 S\u00e3o Luis, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhtar","family":"Hayat","sequence":"additional","affiliation":[{"name":"BAE Laboratory, Universit\u00e9 de Perpignan Via Domitia, 52 Avenue Paul Alduy, Perpignan 66860, France"},{"name":"Interdisciplinary Research Centre in Biomedical Materials (IRCBM) COMSATS Institute of Information Technology (CIIT), Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Marty","sequence":"additional","affiliation":[{"name":"BAE Laboratory, Universit\u00e9 de Perpignan Via Domitia, 52 Avenue Paul Alduy, Perpignan 66860, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nikolelis, D.P., and Nikoleli, G.-P. (2016). Biosensors for Security and Bioterrorism Applications, Springer International Publishing.","DOI":"10.1007\/978-3-319-28926-7"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bios.2016.06.083","article-title":"New biorecognition molecules in biosensors for the detection of toxins","volume":"87","author":"Bazin","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_3","unstructured":"Lehninger, A.L. (1977). Biochemistry, Worth Publishers. [2nd ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0956-5663(94)80038-3","article-title":"Biochemical aspects of biosensors","volume":"9","author":"Byfield","year":"1994","journal-title":"Biosens. Bioelectron."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1002\/elan.201600181","article-title":"An overview of recent electrochemical immunosensing strategies for mycotoxins detection","volume":"28","author":"Catanante","year":"2016","journal-title":"Electroanalysis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jid.2013.521","article-title":"Antibody phage display: Technique and applications","volume":"134","author":"Hammers","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/clinchem\/45.9.1628","article-title":"Aptamers: An emerging class of molecules that rival antibodies in diagnostics","volume":"45","author":"Jayasena","year":"1999","journal-title":"Clin. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.foodcont.2012.01.060","article-title":"Recent advances in ochratoxin a-producing fungi detection based on pcr methods and ochratoxin a analysis in food matrices","volume":"26","author":"Hayat","year":"2012","journal-title":"Food Control"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bios.2014.01.045","article-title":"Development of an ultrasensitive aptasensor for the detection of aflatoxin B 1","volume":"56","author":"Guo","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1021\/ac062186b","article-title":"Real-Time rolling circle amplification for protein detection","volume":"79","author":"Yang","year":"2007","journal-title":"Anal. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1002\/anie.200602754","article-title":"A virus spotlighted by an autonomous DNA machine","volume":"45","author":"Weizmann","year":"2006","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1002\/1521-3773(20020916)41:18<3398::AID-ANIE3398>3.0.CO;2-W","article-title":"Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator","volume":"41","author":"Patolsky","year":"2002","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1021\/ac800958a","article-title":"Impedimetric aptasensor with femtomolar sensitivity based on the enlargement of surface-charged gold nanoparticles","volume":"81","author":"Deng","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11768","DOI":"10.1021\/ja046970u","article-title":"Aptamer-Functionalized Au nanoparticles for the amplified optical detection of thrombin","volume":"126","author":"Pavlov","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1099\/0022-1317-80-9-2501","article-title":"Detection of the human hepatitis b virus x-protein in transgenic mice after radioactive labelling at a newly introduced phosphorylation site","volume":"80","author":"Schmitteckert","year":"1999","journal-title":"J. Gen. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1872-2040(10)60423-9","article-title":"An aptamer-based fluorescence assay for ochratoxin A","volume":"39","author":"Duan","year":"2011","journal-title":"Chin. J. Anal. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1016\/j.bios.2010.09.032","article-title":"Aptamer-Based colorimetric biosensing of ochratoxin a using unmodified gold nanoparticles indicator","volume":"26","author":"Yang","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.snb.2012.09.111","article-title":"Development of an automated flow-based electrochemical aptasensor for on-line detection of ochratoxin A","volume":"176","author":"Rhouati","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/elan.200603855","article-title":"Label-Free impedance biosensors: Opportunities and challenges","volume":"19","author":"Daniels","year":"2007","journal-title":"Electroanalysis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/asia.200900660","article-title":"Homogeneous analysis: Label-free and substrate-free aptasensors","volume":"5","author":"Li","year":"2010","journal-title":"Chem.\u2013An Asian J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1039\/c0nr00201a","article-title":"Label-Free biological and chemical sensors","volume":"2","author":"Hunt","year":"2010","journal-title":"Nanoscale"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1021\/acs.analchem.5b00890","article-title":"Label-Free impedimetric aptasensor for ochratoxin-a detection using iridium oxide nanoparticles","volume":"87","author":"Rivas","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1039\/c3cs60077g","article-title":"Electrical biosensors and the label free detection of protein disease biomarkers","volume":"42","author":"Luo","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1039\/c1cc10563a","article-title":"A simple and label-free sensor for mercury (ii) detection in aqueous solution by malachite green based on a resonance scattering spectral assay","volume":"47","author":"Wu","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"B\u00fclb\u00fcl, G., Hayat, A., and Andreescu, S. (2016). Ssdna functionalized nanoceria: A redox active aptaswitch for biomolecular recognition. Adv. Healthc. Mater.","DOI":"10.1002\/adhm.201500705"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","article-title":"In vitro selection of rna molecules that bind specific ligands","volume":"346","author":"Ellington","year":"1990","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.3390\/toxins5111988","article-title":"Aptamers: A promising tool for ochratoxin a detection in food analysis","volume":"5","author":"Rhouati","year":"2013","journal-title":"Toxins"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1021\/ar300011g","article-title":"\u201cFitting\u201d makes \u201csensing\u201d simple: Label-Free detection strategies based on nucleic acid aptamers","volume":"46","author":"Du","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bios.2013.07.037","article-title":"Colorimetric detection of controlled assembly and disassembly of aptamers on unmodified gold nanoparticles","volume":"51","author":"Gopinath","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.trac.2008.03.003","article-title":"Aptamers as recognition elements for label-free analytical devices","volume":"27","year":"2008","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bios.2012.01.002","article-title":"Assays for aptamer-based platforms","volume":"34","author":"Citartan","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1021\/ac901849k","article-title":"Direct optical detection of aptamer conformational changes induced by target molecules","volume":"81","author":"Neumann","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15187","DOI":"10.3390\/s131115187","article-title":"Recent advances and achievements in nanomaterial-based, and structure switchable aptasensing platforms for ochratoxin a detection","volume":"13","author":"Hayat","year":"2013","journal-title":"Sensors"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/ac0519864","article-title":"Nucleic acid-functionalized pt nanoparticles: Catalytic labels for the amplified electrochemical detection of biomolecules","volume":"78","author":"Polsky","year":"2006","journal-title":"Anal. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/chem.200305470","article-title":"Structure-Switching signaling aptamers: Transducing molecular recognition into fluorescence signaling","volume":"10","author":"Nutiu","year":"2004","journal-title":"Chem.\u2013A Eur. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1039\/b506571b","article-title":"Aptamer biosensor for label-free impedance spectroscopy detection of proteins based on recognition-induced switching of the surface charge","volume":"34","author":"Rodriguez","year":"2005","journal-title":"Chem. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1021\/ac900527f","article-title":"Electrochemical sensor for mercury (ii) based on conformational switch mediated by interstrand cooperative coordination","volume":"81","author":"Liu","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioelechem.2009.04.007","article-title":"Design and testing of aptamer-based electrochemical biosensors for proteins and small molecules","volume":"77","author":"Cheng","year":"2009","journal-title":"Bioelectrochemistry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1021\/ja037289f","article-title":"Optical sensors based on hybrid aptamer\/conjugated polymer complexes","volume":"126","author":"Ho","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bios.2014.03.014","article-title":"Optical aptasensors for quantitative detection of small biomolecules: A review","volume":"59","author":"Feng","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.elecom.2008.01.024","article-title":"Label-Free electrochemical detection of nanomolar adenosine based on target-induced aptamer displacement","volume":"10","author":"Feng","year":"2008","journal-title":"Electrochem. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17990","DOI":"10.1021\/ja056555h","article-title":"A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement","volume":"127","author":"Xiao","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1021\/ac902416u","article-title":"Fluorescence aptameric sensor for strand displacement amplification detection of cocaine","volume":"82","author":"He","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bios.2009.06.001","article-title":"Label-Free and sensitive faradic impedance aptasensor for the determination of lysozyme based on target-induced aptamer displacement","volume":"25","author":"Peng","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1002\/anie.200604524","article-title":"Electronic aptamer-based sensors","volume":"46","author":"Willner","year":"2007","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.snb.2011.03.048","article-title":"Aptamer biosensor for label-free impedance spectroscopy detection of thrombin based on gold nanoparticles","volume":"157","author":"Li","year":"2011","journal-title":"Sens. Actuators B Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.bios.2010.12.012","article-title":"Surface immobilization of DNA aptamers for biosensing and protein interaction analysis","volume":"26","author":"Zhang","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00216-007-1587-2","article-title":"Surface immobilization methods for aptamer diagnostic applications","volume":"390","author":"Balamurugan","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1039\/c0cs00056f","article-title":"Immobilization of bio-macromolecules on self-assembled monolayers: Methods and sensor applications","volume":"40","author":"Samanta","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/adt.2006.4.583","article-title":"Label-Free cell-based assays with optical biosensors in drug discovery","volume":"4","author":"Fang","year":"2006","journal-title":"Assay Drug Dev. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1021\/ac3037443","article-title":"Label-Free colorimetric aptasensor based on nicking enzyme assisted signal amplification and dnazyme amplification for highly sensitive detection of protein","volume":"85","author":"Huang","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1021\/ac900188y","article-title":"Label-Free colorimetric detection of aqueous mercury ion (Hg2+) using Hg2+-modulated g-quadruplex-based dnazymes","volume":"81","author":"Li","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bios.2011.12.011","article-title":"Aptamer-Dnazyme hairpins for biosensing of ochratoxin a","volume":"32","author":"Yang","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.bios.2004.11.006","article-title":"Analytical applications of aptamers","volume":"20","author":"Tombelli","year":"2005","journal-title":"Biosens. Bioelectron."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.3390\/s7123442","article-title":"An overview of label-free electrochemical protein sensors","volume":"7","author":"Vestergaard","year":"2007","journal-title":"Sensors"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.anchem.012809.102211","article-title":"Electrochemical impedance spectroscopy","volume":"3","author":"Chang","year":"2010","journal-title":"Ann. Rev. Anal. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1039\/C2CS35293A","article-title":"Biosensors based on nanomechanical systems","volume":"42","author":"Tamayo","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0925-4005(01)00856-5","article-title":"Micromechanical cantilever-based biosensors","volume":"79","author":"Raiteri","year":"2001","journal-title":"Sens. Actuators B Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1002\/1521-3773(20001117)39:22<4004::AID-ANIE4004>3.0.CO;2-2","article-title":"Piezoelectric mass-sensing devices as biosensors\u2014An alternative to optical biosensors?","volume":"39","author":"Janshoff","year":"2000","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jscs.2010.06.006","article-title":"Impact of mycotoxins on humans and animals","volume":"15","author":"Zain","year":"2011","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/09637486.2015.1034251","article-title":"Emerging nanotechnology for detection of mycotoxins in food and feed","volume":"66","author":"Rai","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.talanta.2013.07.011","article-title":"Rapid high-throughput analysis of ochratoxin a by the self-assembly of dnazyme\u2013aptamer conjugates in wine","volume":"116","author":"Yang","year":"2013","journal-title":"Talanta"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aca.2014.12.031","article-title":"Label-Free colorimetric aptasensor for sensitive detection of ochratoxin a utilizing hybridization chain reaction","volume":"860","author":"Wang","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.bios.2012.09.053","article-title":"A signal-on fluorescent aptasensor based on Tb3+ and structure-switching aptamer for label-free detection of ochratoxin a in wheat","volume":"41","author":"Zhang","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lv, Z., Chen, A., Liu, J., Guan, Z., Zhou, Y., Xu, S., Yang, S., and Li, C. (2014). A simple and sensitive approach for ochratoxin a detection using a label-free fluorescent aptasensor. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085968"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/toxins6082435","article-title":"Selection and characterization of a novel DNA aptamer for label-free fluorescence biosensing of ochratoxin A","volume":"6","author":"McKeague","year":"2014","journal-title":"Toxins"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1021\/acsami.5b01702","article-title":"Label-Free luminescent switch-on probe for ochratoxin a detection using a g-quadruplex-selective iridium (iii) complex","volume":"7","author":"Lu","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bios.2014.03.059","article-title":"A regeneratable, label-free, localized surface plasmon resonance (lspr) aptasensor for the detection of ochratoxin A","volume":"59","author":"Park","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1016\/j.bios.2011.03.014","article-title":"Polyaniline langmuir-blodgett film based aptasensor for ochratoxin a detection","volume":"26","author":"Prabhakar","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/elan.201100485","article-title":"Impedimetric DNA aptasensor for sensitive detection of ochratoxin a in food","volume":"24","author":"Castillo","year":"2012","journal-title":"Electroanalysis"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.talanta.2012.09.048","article-title":"Highly sensitive ochratoxin a impedimetric aptasensor based on the immobilization of azido-aptamer onto electrografted binary film via click chemistry","volume":"103","author":"Hayat","year":"2013","journal-title":"Talanta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.aca.2015.06.052","article-title":"A label free aptasensor for ochratoxin A detection in cocoa beans: An application to chocolate industries","volume":"889","author":"Mishra","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bios.2013.01.059","article-title":"Design of peg-aptamer two piece macromolecules as convenient and integrated sensing platform: Application to the label free detection of small size molecules","volume":"45","author":"Hayat","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1039\/c3an00158j","article-title":"Electrochemical grafting of long spacer arms of hexamethyldiamine on a screen printed carbon electrode surface: Application in target induced ochratoxin a electrochemical aptasensor","volume":"138","author":"Hayat","year":"2013","journal-title":"Analyst"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16129","DOI":"10.3390\/s131216129","article-title":"Impedimetric aptasensor for ochratoxin a determination based on au nanoparticles stabilized with hyper-branched polymer","volume":"13","author":"Evtugyn","year":"2013","journal-title":"Sensors"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bios.2016.08.108","article-title":"Biomolecular detection at ssdna-conjugated nanoparticles by nano-impact electrochemistry","volume":"87","author":"Karimi","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00604-014-1420-5","article-title":"Visual and microplate detection of aflatoxin b2 based on nacl-induced aggregation of aptamer-modified gold nanoparticles","volume":"182","author":"Luan","year":"2015","journal-title":"Microchim. Acta"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1166\/jnn.2015.9225","article-title":"Rapid visual detection of aflatoxin b1 by label-free aptasensor using unmodified gold nanoparticles","volume":"15","author":"Luan","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.aca.2015.05.041","article-title":"A structure-switchable aptasensor for aflatoxin b1 detection based on assembly of an aptamer\/split dnazyme","volume":"886","author":"Seok","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.foodcont.2013.07.042","article-title":"Chemiluminescence competitive aptamer assay for the detection of aflatoxin b1 in corn samples","volume":"36","author":"Shim","year":"2014","journal-title":"Food Control"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bios.2014.02.001","article-title":"A fluorescent aptasensor based on DNA-scaffolded silver-nanocluster for ochratoxin a detection","volume":"57","author":"Chen","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.msec.2013.01.044","article-title":"Label-Free detection of aflatoxin m1 with electrochemical Fe3O4\/polyaniline-based aptasensor","volume":"33","author":"Nguyen","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.talanta.2015.09.012","article-title":"Development of an impedimetric aptasensor for the determination of aflatoxin m1 in milk","volume":"146","author":"Paniel","year":"2016","journal-title":"Talanta"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.snb.2016.05.112","article-title":"Disposable and portable electrochemical aptasensor for label free detection of aflatoxin b1 in alcoholic beverages","volume":"235","author":"Goud","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodcont.2014.12.008","article-title":"Detection of aflatoxin b1 by aptamer-based biosensor using pamam dendrimers as immobilization platform","volume":"52","author":"Castillo","year":"2015","journal-title":"Food Control"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00604-015-1492-x","article-title":"Impedimetric aptamer-based determination of the mold toxin fumonisin b1","volume":"182","author":"Chen","year":"2015","journal-title":"Microchim. Acta"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"35448","DOI":"10.1039\/C5RA04278J","article-title":"Aptamer-Based microcantilever array biosensor for detection of fumonisin b-1","volume":"5","author":"Chen","year":"2015","journal-title":"RSC Adv."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"16292","DOI":"10.3390\/s131216292","article-title":"Aptamer-Based analysis: A promising alternative for food safety control","volume":"13","year":"2013","journal-title":"Sensors"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"10456","DOI":"10.1021\/jf801957h","article-title":"Determination of ochratoxin a with a DNA aptamer","volume":"56","author":"Penner","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_90","unstructured":"Le, L.C., Cruz-Aguado, J.A., and Penner, G.A. (2012). Dna ligands for aflatoxin and zearalenone. (13\/391,426), U.S. Patent."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.foodcont.2014.07.037","article-title":"Selection, characterization and application of aptamers targeted to aflatoxin b2","volume":"47","author":"Ma","year":"2015","journal-title":"Food Control"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jmr.2370","article-title":"Selection of aptamers for aflatoxin m1 and their characterization","volume":"27","author":"Malhotra","year":"2014","journal-title":"Jo. Mol. Recognit."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.3390\/ijms11124864","article-title":"Screening and initial binding assessment of fumonisin b1 aptamers","volume":"11","author":"McKeague","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00604-014-1260-3","article-title":"Selection and characterization of single stranded DNA aptamers recognizing fumonisin b1","volume":"181","author":"Chen","year":"2014","journal-title":"Microchim. Acta"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1007\/s00216-013-7085-9","article-title":"Selection and identification of ssdna aptamers recognizing zearalenone","volume":"405","author":"Chen","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"865","DOI":"10.5740\/jaoacint.16-0114","article-title":"Current status and future prospects for aptamer-based mycotoxin detection","volume":"99","author":"Ruscito","year":"2016","journal-title":"J. AOAC Int."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhou, J., and Rossi, J. (2016). Aptamers as targeted therapeutics: Current potential and challenges. Nat. Rev. Drug Discov.","DOI":"10.1038\/nrd.2016.199"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Mascini, M. (2009). Aptamers in Bioanalysis, Wiley.","DOI":"10.1002\/9780470380772"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0968-0896(97)00044-8","article-title":"Post-selex combinatorial optimization of aptamers","volume":"5","author":"Eaton","year":"1997","journal-title":"Bioorgan. Med. Chem."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/16\/12\/2178\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:28:51Z","timestamp":1760210931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/16\/12\/2178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,18]]},"references-count":99,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12]]}},"alternative-id":["s16122178"],"URL":"https:\/\/doi.org\/10.3390\/s16122178","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,18]]}}}