{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:24:20Z","timestamp":1761060260279,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A curved D-type optical fiber sensor (OFS) combined with a microfluidic chip is proposed. This OFS, based on surface plasmon resonance (SPR) of the Kretchmann\u2019s configuration, is applied as a biosensor to measure the concentrations of different bio-liquids such as ethanol, methanol, and glucose solutions. The SPR phenomenon is attained by using the optical fiber to guide the light source to reach the side-polished, gold-coated region. Integrating this OFS with a polymethylmethacrylate (PMMA)-based microfluidic chip, the SPR spectra for liquids with different refractive indices are recorded. Experimentally, the sensitivity of the current biosensor was calculated to be in the order of 10\u22125 RIU. This microfluidic chip-integrated OFS could be valuable for monitoring subtle changes in biological samples such as blood sugar, allergen, and biomolecular interactions.<\/jats:p>","DOI":"10.3390\/s17010063","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T08:48:53Z","timestamp":1483087733000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Integration of Curved D-Type Optical Fiber Sensor with Microfluidic Chip"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-0251","authenticated-orcid":false,"given":"Yung-Shin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Physics, Fu-Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Jyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physics, Fu-Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Cherng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Physics, Fu-Jen Catholic University, New Taipei City 24205, Taiwan"},{"name":"Graduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City 24205, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1007\/s00216-015-8607-4","article-title":"Rapid and label-free detection of egg allergen traces in wines by surface plasmon resonance biosensor","volume":"407","author":"Pilolli","year":"2015","journal-title":"Anal. 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