{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:20:35Z","timestamp":1776756035933,"version":"3.51.2"},"reference-count":39,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A flow-electrolytic cell that consists of a bare gold wire or of different thiol-compound-modified gold electrodes (such as 2,4-thiazolidinedione, 2-mercapto-5-thiazoline, 2-mercaptothiazoline, l-cysteine, thioglycolic acid) was designed to be used in a voltammetric detector to identify l-selenomethionine and Se-methylseleno-l-cysteine using high-performance liquid chromatography. Both l-selenomethionine and Se-methylseleno-l-cysteine are more efficiently electrochemically oxidized on a thiol\/gold than on a bare gold electrode. For the DC mode, and for measurements with suitable experimental parameters, a linear concentration from 10 to 1600 ng\u00b7mL\u22121 was found. The limits of quantification for l-selenomethionine and Se-methylseleno-l-cysteine were below 10 ng\u00b7mL\u22121. The method can be applied to the quantitative determination of l-selenomethionine and Se-methylseleno-l-cysteine in commercial selenium-containing supplement products. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.<\/jats:p>","DOI":"10.3390\/s17020383","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T12:55:34Z","timestamp":1487249734000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor"],"prefix":"10.3390","volume":"17","author":[{"given":"Lai-Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Rende, Tainan 71743, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Rende, Tainan 71743, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.theriogenology.2012.03.008","article-title":"Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary","volume":"78","author":"Rezvanfar","year":"2012","journal-title":"Theriogenology"},{"key":"ref_2","first-page":"199","article-title":"Bacteriostasis experiment in vitro of Se-enriched herbal medicine compound prescription to Escherichia coli and Salmonella","volume":"25","author":"Zeng","year":"2007","journal-title":"J. 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