{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:53:10Z","timestamp":1784433190505,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Radiopacity is a critical property of materials that are used for a range of radiological applications, including the development of phantom devices that emulate the radiodensity of native tissues and the production of protective equipment for personnel handling radioactive materials. Three-dimensional (3D) printing is a fabrication platform that is well suited to creating complex anatomical replicas or custom labware to accomplish these radiological purposes. We created and tested multiple ABS (Acrylonitrile butadiene styrene) filaments infused with varied concentrations of bismuth (1.2\u20132.7 g\/cm3), a radiopaque metal that is compatible with plastic infusion, to address the poor gamma radiation attenuation of many mainstream 3D printing materials. X-ray computed tomography (CT) experiments of these filaments indicated that a density of 1.2 g\/cm3 of bismuth-infused ABS emulates bone radiopacity during X-ray CT imaging on preclinical and clinical scanners. ABS-bismuth filaments along with ABS were 3D printed to create an embedded human nasocranial anatomical phantom that mimicked radiological properties of native bone and soft tissue. Increasing the bismuth content in the filaments to 2.7 g\/cm3 created a stable material that could attenuate 50% of 99mTechnetium gamma emission when printed with a 2.0 mm wall thickness. A shielded test tube rack was printed to attenuate source radiation as a protective measure for lab personnel. We demonstrated the utility of novel filaments to serve multiple radiological purposes, including the creation of anthropomorphic phantoms and safety labware, by tuning the level of radiation attenuation through material customization.<\/jats:p>","DOI":"10.3390\/s17030459","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T11:19:50Z","timestamp":1487935190000},"page":"459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Bismuth Infusion of ABS Enables Additive Manufacturing of Complex Radiological Phantoms and Shielding Equipment"],"prefix":"10.3390","volume":"17","author":[{"given":"Justin","family":"Ceh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, 100 Galvin Life Science Center, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Youd","sequence":"additional","affiliation":[{"name":"Turner MedTech Inc., 1119 South 1680 West, Orem, UT 84058, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zach","family":"Mastrovich","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, 100 Galvin Life Science Center, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Peterson","sequence":"additional","affiliation":[{"name":"Turner MedTech Inc., 1119 South 1680 West, Orem, UT 84058, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, 100 Galvin Life Science Center, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Sasser","sequence":"additional","affiliation":[{"name":"Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Department of Chemistry and Biochemistry, University of Notre Dame, 236 Nieuwland Science Hall, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, 100 Galvin Life Science Center, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Doney","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, 100 Galvin Life Science Center, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark","family":"Turner","sequence":"additional","affiliation":[{"name":"Turner MedTech Inc., 1119 South 1680 West, Orem, UT 84058, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Leevy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Notre Dame, 100 Galvin Life Science Center, Notre Dame, IN 46556, USA"},{"name":"Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA"},{"name":"Harper Cancer Research Institute, University of Notre Dame, 1234 N Notre Dame Avenue, South Bend, IN 46617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0895-6111(94)00043-3","article-title":"Biomedical imaging modalities: A tutorial","volume":"19","author":"Acharya","year":"1995","journal-title":"Comput. Med. Imag. Graph."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1088\/0031-9155\/51\/13\/R03","article-title":"X-ray computed tomography","volume":"51","author":"Kalender","year":"2006","journal-title":"Phys. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1118\/1.2198187","article-title":"A geometric calibration method for cone beam CT systems","volume":"33","author":"Yang","year":"2006","journal-title":"Med. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"014007","DOI":"10.1117\/1.2170579","article-title":"Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons","volume":"11","author":"Lomnes","year":"2006","journal-title":"J. Biomed. Opt."},{"key":"ref_5","unstructured":"Cotteleer, M.J., and Joyce, J. (2014). D Opportunity: Additive Manufacturing Paths to Performance, Innovation, and Growth. Deloitte Rev., Available online: http:\/\/cellular3d.com\/images\/marketresearch\/SIMT_AM_Conference_Keynote-Oct2014.pdf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1021\/ac403397r","article-title":"Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences","volume":"86","author":"Gross","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11548-010-0476-x","article-title":"3D printing based on imaging data: Review of medical applications","volume":"5","author":"Rengier","year":"2010","journal-title":"Int. J. CARS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.mattod.2013.11.017","article-title":"Bone tissue engineering using 3D printing","volume":"16","author":"Bose","year":"2013","journal-title":"Mater. Today"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1016\/j.biomaterials.2012.04.050","article-title":"A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering","volume":"33","author":"Billiet","year":"2012","journal-title":"Biomaterials"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nbt.2958","article-title":"3D bioprinting of tissues and organs","volume":"32","author":"Murphy","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ase.1345","article-title":"\u201cLet\u2019s get physical\u201d: Advantages of a physical model over 3D computer models and textbooks in learning imaging anatomy","volume":"6","author":"Preece","year":"2013","journal-title":"Anat. Sci. Educ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3171\/2013.11.JNS131066","article-title":"Utility of multimaterial 3D printers in creating models with pathological entities to enhance the training experience of neurosurgeons","volume":"120","author":"Waran","year":"2014","journal-title":"J. Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Salmi, M. (2016). Possibilities of preoperative medical models made by 3D printing or additive manufacturing. J. Med. Eng., 6191526.","DOI":"10.1155\/2016\/6191526"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/1553350614524838","article-title":"A novel classification and online platform for planning and documentation of medical applications of additive manufacturing","volume":"21","author":"Tuomi","year":"2014","journal-title":"Surg. Innov."},{"key":"ref_15","unstructured":"Salmi, M. (2013). Medical Applications of Additive Manufacturing in Surgery and Dental Care. [Ph.D. Thesis, Aalto University]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"082502","DOI":"10.1118\/1.4887854","article-title":"Development of patient-specific molecular imaging phantoms using a 3D printer","volume":"41","author":"Gear","year":"2014","journal-title":"Med. Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1109\/LAWP.2012.2236293","article-title":"MRI-derived 3-D-printed breast phantom for microwave breast imaging validation","volume":"11","author":"Burfeindt","year":"2012","journal-title":"IEEE Antennas Wirel. Propag. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1364\/OL.39.003010","article-title":"Three-dimensional printing of tissue phantoms for biophotonic imaging","volume":"39","author":"Wang","year":"2014","journal-title":"Opt. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1118\/1.3533896","article-title":"Development of a physical 3D anthropomorphic breast phantom","volume":"38","author":"Carton","year":"2011","journal-title":"Med. Phys."},{"key":"ref_20","unstructured":"Miller, M.A., and Hutchins, G.D. (November, January 26). Development of anatomically realistic PET and PET\/CT phantoms with rapid prototyping technology. Proceedings of the IEEE Nuclear Science Symposium Conference Record, Piscataway, NJ, USA."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1089\/3dp.2013.0010","article-title":"3D-printed tissue-mimicking phantoms for medical imaging and computational validation applications","volume":"1","author":"Cloonan","year":"2014","journal-title":"3D Print Addit. Manuf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"894509","DOI":"10.1117\/12.2041137","article-title":"3D printing method for freeform fabrication of optical phantoms simulating heterogeneous biological tissue","volume":"8945","author":"Wang","year":"2014","journal-title":"Proc. SPIE"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.matdes.2015.07.052","article-title":"Additive manufacture of custom radiation dosimetry phantoms: An automated method compatible with commercial polymer 3D printers","volume":"86","author":"Leary","year":"2015","journal-title":"Mater. Des."},{"key":"ref_24","unstructured":"3D Slicer. Available online: http:\/\/pubs.acs.org."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Thali, M., Dirnhofer, R., and Vock, P. (2009). The Virtopsy Approach: 3D Optical and Radiological Scanning and Reconstruction in Forensic Medicine, CRC Press. [1st ed.].","DOI":"10.1201\/9780849381898"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.oooo.2013.04.013","article-title":"Prospects and challenges of rendering tissue density in Hounsfield units for cone beam computed tomography","volume":"116","author":"Molteni","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2106\/JBJS.J.00160","article-title":"Hounsfield units for assessing bone mineral density and strength: A tool for osteoporosis management","volume":"93","author":"Schreiber","year":"2011","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1108\/13552540510623611","article-title":"Rapid manufacturing of patient-specific shielding masks, using RP in parallel with metal spraying","volume":"11","author":"Truscott","year":"2005","journal-title":"Rapid Prototyp. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.prosdent.2007.02.005","article-title":"Rapid prototyping technique for creating a radiation shield","volume":"97","author":"Zemnick","year":"2007","journal-title":"J. Prosthet. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1016\/j.biomaterials.2012.09.019","article-title":"PEG modified BaGdF5:Yb\/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging","volume":"33","author":"Zeng","year":"2012","journal-title":"Biomaterials"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.nimb.2010.12.054","article-title":"Nanoparticles of Al2O3:Cr as a sensitive thermoluminescent material for high exposures of gamma rays irradiations","volume":"269","author":"Salah","year":"2011","journal-title":"Nucl Instr. Methods Phys. Res. 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