{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:11:43Z","timestamp":1760242303690,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01 EZ 0867","01 GQ 1106"],"award-info":[{"award-number":["01 EZ 0867","01 GQ 1106"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LA 1471\/11-1"],"award-info":[{"award-number":["LA 1471\/11-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007837","name":"University of Bremen","doi-asserted-by":"publisher","award":["Research-Focus Neurotechnology","Creative Unit I-See 'The artificial eye: Chronic wireless interface to the visual cortex'"],"award-info":[{"award-number":["Research-Focus Neurotechnology","Creative Unit I-See 'The artificial eye: Chronic wireless interface to the visual cortex'"]}],"id":[{"id":"10.13039\/501100007837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Implantable neuronal interfaces to the brain are an important keystone for future medical applications. However, entering this field of research is difficult since such an implant requires components from many different areas of technology. Since the complete avoidance of wires is important due to the risk of infections and other long-term problems, means for wirelessly transmitting data and energy are a necessity which adds to the requirements. In recent literature, many high-tech components for such implants are presented with remarkable properties. However, these components are typically not freely available for such a system. Every group needs to re-develop their own solution. This raises the question if it is possible to create a reusable design for an implant and its external base-station, such that it allows other groups to use it as a starting point. In this article, we try to answer this question by presenting a design based exclusively on commercial off-the-shelf components and studying the properties of the resulting system. Following this idea, we present a fully wireless neuronal implant for simultaneously measuring electrocorticography signals at 128 locations from the surface of the brain. All design files are available as open source.<\/jats:p>","DOI":"10.3390\/s17040761","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T10:15:12Z","timestamp":1491300912000},"page":"761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Implications for a Wireless, External Device System to Study Electrocorticography"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-4879","authenticated-orcid":false,"given":"David","family":"Rotermund","sequence":"first","affiliation":[{"name":"Institute for Theoretical Physics, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Pistor","sequence":"additional","affiliation":[{"name":"Institute of Electrodynamics and Microelectronics, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janpeter","family":"Hoeffmann","sequence":"additional","affiliation":[{"name":"Institute of Electrodynamics and Microelectronics, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Schellenberg","sequence":"additional","affiliation":[{"name":"RF and Microwave Engineering Laboratory, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy","family":"Boll","sequence":"additional","affiliation":[{"name":"Institute for Microsensors, -Actuators and -Systems, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tolstosheeva","sequence":"additional","affiliation":[{"name":"Institute for Microsensors, -Actuators and -Systems, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Gauck","sequence":"additional","affiliation":[{"name":"Institute for Brain Research, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Stemmann","sequence":"additional","affiliation":[{"name":"Institute for Brain Research, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Peters-Drolshagen","sequence":"additional","affiliation":[{"name":"Institute of Electrodynamics and Microelectronics, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kreiter","sequence":"additional","affiliation":[{"name":"Institute for Brain Research, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schneider","sequence":"additional","affiliation":[{"name":"RF and Microwave Engineering Laboratory, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Paul","sequence":"additional","affiliation":[{"name":"Institute of Electrodynamics and Microelectronics, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute for Microsensors, -Actuators and -Systems, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Pawelzik","sequence":"additional","affiliation":[{"name":"Institute for Theoretical Physics, University of Bremen, 28359 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/S1807-59322011001300004","article-title":"Future developments in brain-machine interface research","volume":"66","author":"Lebedev","year":"2011","journal-title":"Clinics (Sao Paulo)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"041001","DOI":"10.1088\/1741-2560\/6\/4\/041001","article-title":"The brain\u2013computer interface cycle","volume":"6","author":"Farquhar","year":"2009","journal-title":"J. Neural Eng."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tins.2006.07.004","article-title":"Brain-machine interfaces: Past, present and future","volume":"29","author":"Lebedev","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev.psych.093008.100503","article-title":"Cognitive Neural Prosthetics","volume":"61","author":"Andersen","year":"2010","journal-title":"Annu. Rev. Psychol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/nature06996","article-title":"Cortical control of a prosthetic arm for self-feeding","volume":"453","author":"Velliste","year":"2008","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wang, W., Collinger, J.L., Degenhart, A.D., Tyler-Kabara, E.C., Schwartz, A.B., Moran, D.W., Weber, D.J., Wodlinger, B., Vinjamuri, R.K., and Ashmore, R.C. (2013). An electrocorticographic brain interface in an individual with tetraplegia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055344"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature04970","article-title":"Neuronal ensemble control of prosthetic devices by a human with tetraplegia","volume":"442","author":"Hochberg","year":"2006","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.1097938","article-title":"Cognitive Control Signals for Neural Prosthetics","volume":"305","author":"Musallam","year":"2004","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.conb.2010.09.010","article-title":"Evolution of brain\u2013computer interface: Action potentials, local field potentials and electrocorticograms","volume":"20","author":"Moran","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"313ra179","DOI":"10.1126\/scitranslmed.aac7328","article-title":"Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface","volume":"7","author":"Jarosiewicz","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_11","first-page":"9","article-title":"Can Electrocorticography (ECoG) Support Robust and Powerful Brain\u2013Computer Interfaces?","volume":"3","author":"Schalk","year":"2010","journal-title":"Front. Neuroeng."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Silay, K.M., Dehollain, C., and Declercq, M. (2008, January 20\u201325). Numerical analysis of temperature elevation in the head due to power dissipation in a cortical implant. Proceedings of the 30th Annual International Conference of the IEEE, Engineering in Medicine and Biology Society, Vancouver, BC, Canada.","DOI":"10.1109\/IEMBS.2008.4649312"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kim, S., Tathireddy, P., Normann, R.A., and Solzbacher, F. (2007, January 2\u20135). In vitro and in vivo study of temperature increases in the brain due to a neural implant. Proceedings of the 3rd International IEEE\/EMBS Conference on Neural Engineering, Kohala Coast, HI, USA.","DOI":"10.1109\/CNE.2007.369637"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1109\/TNSRE.2007.908429","article-title":"Thermal Impact of an Active 3-D Microelectrode Array Implanted in the Brain","volume":"15","author":"Kim","year":"2007","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/jnnp.2005.081232","article-title":"Deep-brain stimulation: Long-term analysis of complications caused by hardware and surgery\u2014Experiences from a single centre","volume":"77","author":"Voges","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0090-3019(00)00324-4","article-title":"Complications and results of subdural grid electrode implantation in epilepsy surgery","volume":"54","author":"Lee","year":"2000","journal-title":"Surg. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clinph.2007.09.117","article-title":"Chronic subdural electrodes in the management of epilepsy","volume":"119","author":"Nair","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1109\/TBCAS.2014.2370794","article-title":"Optimal design of wireless power transmission links for millimeter-sized biomedical implants","volume":"10","author":"Ahn","year":"2016","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1109\/TBCAS.2015.2393878","article-title":"Flexible, polarization-diverse UWB antennas for implantable neural recording systems","volume":"10","author":"Bahrami","year":"2016","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"026010","DOI":"10.1088\/1741-2560\/10\/2\/026010","article-title":"An implantable wireless neural interface for recording cortical circuit dynamics in moving primates","volume":"10","author":"Borton","year":"2013","journal-title":"J. Neural Eng."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Muller, R., Hanh-Phuc, L., Wen, L., Ledochowitsch, P., Gambini, S., Bjorninen, T., Koralek, A., Carmena, J., Maharbiz, M., and Alon, E. (2014, January 9\u201313). 24.1 A miniaturized 64-channel 225 \u03bcW wireless electrocorticographic neural sensor. Proceedings of the Solid-State Circuits Conference Digest of Technical Papers (ISSCC), San Francisco, CA, USA.","DOI":"10.1109\/ISSCC.2014.6757492"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1587\/transcom.E94.B.2448","article-title":"A Fully-Implantable Wireless System for Human Brain-Machine Interfaces Using Brain Surface Electrodes: W-HERBS","volume":"E94-B","author":"Hirata","year":"2011","journal-title":"IEICE Trans. Commun."},{"key":"ref_23","unstructured":"Aceros, J., Yin, M., Borton, D., Patterson, W., and Nurmikko, A. (September, January 30). A 32-channel fully implantable wireless neurosensor for simultaneous recording from two cortical regions. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, USA."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1109\/TNSRE.2009.2021607","article-title":"A 128-channel 6 mW wireless neural recording IC with spike feature extraction and UWB transmitter","volume":"17","author":"Chae","year":"2009","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_25","unstructured":"Harrison, R.R., Kier, R.J., Kim, S., Rieth, L., Warren, D.J., Ledbetter, N.M., Clark, G.A., Solzbacher, F., Chestek, C.A., and Gilja, V. (2012, January 12\u201314). 100-Channel wireless neural recording system with 54-Mb\/s data link and 40%-efficiency power link. Proceedings of the 2012 IEEE Asian Solid State Circuits Conference (A-SSCC), Kobe, Japan."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wise, K.D. (2009, January 21\u201325). Wireless integrated microsystems: Wearable and implantable devices for improved health care. Proceedings of the 2009 International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS 2009), Denver, CO, USA.","DOI":"10.1109\/SENSOR.2009.5285579"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1109\/TBCAS.2011.2177089","article-title":"Design of ultra-low power biopotential amplifiers for biosignal acquisition applications","volume":"6","author":"Zhang","year":"2012","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_28","unstructured":"TI (bqTESLA Portfolio of Wireless Power Solutions, 2011). bqTESLA Portfolio of Wireless Power Solutions."},{"key":"ref_29","unstructured":"TI (bq25046EVM-687 Evaluation Module, 2010). bq25046EVM-687 Evaluation Module, SLVU420."},{"key":"ref_30","unstructured":"TI (bq51013-Integrated Wireless Power Supply Receiver, Qi (Wireless Power Consortium) Compliant, 2012). bq51013-Integrated Wireless Power Supply Receiver, Qi (Wireless Power Consortium) Compliant, SLVSAT9D."},{"key":"ref_31","unstructured":"Torex (XCL206-Inductor Built-In Step-Down Micro DC\/DC Converters, 2011). XCL206-Inductor Built-In Step-Down Micro DC\/DC Converters."},{"key":"ref_32","unstructured":"Microsemi (ZL70102-Medical Implantable RF Transceiver MICS RF Telemetry, 2010). ZL70102-Medical Implantable RF Transceiver MICS RF Telemetry."},{"key":"ref_33","unstructured":"Nihon Dempa Kogyo Co., Ltd. (NDK) (NZ2016S Series\u2014Crystal Clock Oscillator, 2013). NZ2016S Series\u2014Crystal Clock Oscillator."},{"key":"ref_34","unstructured":"RF Monolithics (RF2607D-403.5 MHz SAW Filter, 2010). RF2607D-403.5 MHz SAW Filter."},{"key":"ref_35","unstructured":"Microsemi (ZL70120 MICS-Band RF Base Station Module (BSM), 2013). ZL70120 MICS-Band RF Base Station Module (BSM), Rev. 4."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"OrangeTreeTechnologies (ZestET1: GigE TOE & FPGA Module, 2013). ZestET1: GigE TOE & FPGA Module.","DOI":"10.1155\/2013\/453872"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Pistor, J., Hoeffmann, J., Rotermund, D., Tolstosheeva, E., Schellenberg, T., Boll, D., Gordillo-Gonzalez, V., Mandon, S., Peters-Drolshagen, D., and Kreiter, A.K. (2013, January 18\u201322). Development of a fully implantable recording system for ECoG signals. Proceedings of the Conference on Design, Automation and Test in Europe, Grenoble, France.","DOI":"10.7873\/DATE.2013.188"},{"key":"ref_38","unstructured":"WPC\u2014Wireless Power Consortium (2017, April 03). Available online: https:\/\/www.wirelesspowerconsortium.com\/data\/downloadables\/1\/2\/1\/4\/20140106-wpc-demonstrates-advanced-resonant-wireless-charging-system-at-ces.pdf."},{"key":"ref_39","unstructured":"IEEE (2017, April 03). Available online: http:\/\/ieeexplore.ieee.org\/document\/1626482\/."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tolstosheeva, E., Hoeffmann, J., Pistor, J., Rotermund, D., Schellenberg, T., Boll, D., Hertzberg, T., Gordillo-Gonzalez, V., Mandon, S., and Peters-Drolshagen, D. (2013, January 16\u201320). Towards a Wireless and fully-implantable ECoG System. Proceedings of the Transducers\u2014The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Barcelona, Spain.","DOI":"10.1109\/Transducers.2013.6626783"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/4\/761\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:31:54Z","timestamp":1760207514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/4\/761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4]]}},"alternative-id":["s17040761"],"URL":"https:\/\/doi.org\/10.3390\/s17040761","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2017,4,4]]}}}