{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:49:34Z","timestamp":1780076974368,"version":"3.54.0"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>This paper presents a ferroelectric polymer-based temperature sensor designed for microfluidic devices. The integration of the sensor into a system-on-a-chip platform facilitates quick monitoring of localized temperature of a biological fluid, avoiding errors in the evaluation of thermal evolution of the fluid during analysis. The contact temperature sensor is fabricated by combining a thin pyroelectric film together with an infrared source, which stimulates the active element located on the top of the microfluidic channel. An experimental setup was assembled to validate the analytical model and to characterize the response rate of the device. The evaluation procedure and the operating range of the temperature also make this device suitable for applications where the localized temperature monitoring of biological samples is necessary. Additionally, ease of integration with standard microfluidic devices makes the proposed sensor an attractive option for in situ analysis of biological fluids.<\/jats:p>","DOI":"10.3390\/s17040850","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T10:55:44Z","timestamp":1492080944000},"page":"850","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["PVDF Sensor Stimulated by Infrared Radiation for Temperature Monitoring in Microfluidic Devices"],"prefix":"10.3390","volume":"17","author":[{"given":"Salvatore","family":"Pullano","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University Magna Gr\u00e6cia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"},{"name":"Department of Electrical Engineering and Computer Science, University of Tennessee, 1520 Middle Drive, Knoxville, TN 37996, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-0880","authenticated-orcid":false,"given":"Ifana","family":"Mahbub","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, University of Tennessee, 1520 Middle Drive, Knoxville, TN 37996, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, University of Tennessee, 1520 Middle Drive, Knoxville, TN 37996, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University Magna Gr\u00e6cia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1109\/MDAT.2015.2491785","article-title":"Lab on a Chip Based on CMOS Technology: System Architectures, Microfluidic Packaging, and Challenges","volume":"32","author":"Ghallab","year":"2015","journal-title":"IEEE Des. Test"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kubicki, W., Walczak, R., and Dziuban, J.A. (2011, January 4\u20137). Miniature instrument for lab-on-a-chip capillary gel electrophoresis of DNA utilizing temperature control technique. Proceedings of the Eurosensors XXV, Athens, Greece.","DOI":"10.1016\/j.proeng.2011.12.305"},{"key":"ref_3","first-page":"725","article-title":"Analysis on PCR chip with reusable electrodes and its temperature field","volume":"38","author":"Cao","year":"2015","journal-title":"Bandaoti Guangdian Semicond. Optoelectron."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.aca.2007.12.044","article-title":"A thermostat chip of indium tin oxide glass substrate for static polymerase chain reaction and in situ real time fluorescence monitoring","volume":"610","author":"Wu","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.sna.2013.01.035","article-title":"Fabrication and characterization of aluminum thin film heaters and temperature sensors on a photopolymer for lab-on-chip systems","volume":"193","author":"Reynolds","year":"2013","journal-title":"Sens. Actuators A Phys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.snb.2012.02.047","article-title":"Integration of nanosensors into a sealed microchannel in a hybrid lab-on-a-chip device","volume":"166\u2013167","author":"Li","year":"2012","journal-title":"Sens. Actuators B Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1115\/1.4005126","article-title":"History, advances, and challenges in liquid flow and flow boiling heat transfer in microchannels: A critical review","volume":"134","author":"Kandlikar","year":"2012","journal-title":"J. Heat Transf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.jeurceramsoc.2008.12.008","article-title":"Novel cold chemical lamination bonding technique\u2014A simple LTCC thermistor-based flow sensor","volume":"29","author":"Roguszczak","year":"2009","journal-title":"J. Ceram. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.optcom.2014.11.064","article-title":"A nanometeric temperature sensor based on plasmonic waveguide with an ethanol-sealed rectangular cavity","volume":"339","author":"Wu","year":"2015","journal-title":"Opt. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Donner, J.S., Thompson, S.A., Kreuzer, M.P., Baffou, G., and Quidant, R. (2013, January 14\u201318). Mapping intracellular temperature using green fluorescent protein-from in vitro to in vivo. Proceedings of the Optical Molecular Probes, Imaging and Drug Delivery, OMP 2013, Waikoloa Beach, HI, USA.","DOI":"10.1364\/OMP.2013.MTh1C.2"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tanimoto, R., Hiraiwa, T., Nakai, Y., Shindo, Y., Oka, K., Hiroi, N., and Funahashi, A. (2016). Detection of Temperature Difference in Neuronal Cells. Sci. Rep., 6.","DOI":"10.1038\/srep22071"},{"key":"ref_12","first-page":"461","article-title":"Thermometry in micro and nanofluidics","volume":"Volume 2016","author":"Carlos","year":"2016","journal-title":"Thermometry at the Nanoscale: Techniques and Selected Applications"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/smll.201502883","article-title":"Submicrometer-Sized Thermometer Particles Exploiting Selective Nucleic Acid Stability","volume":"12","author":"Puddu","year":"2016","journal-title":"Small"},{"key":"ref_14","unstructured":"Measurement Specialties Inc (2016, August 31). Piezo Film Sensors Technical Manual. Available online: https:\/\/www.sparkfun.com\/datasheets\/Sensors\/Flex\/MSI-techman.pdf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.measurement.2015.07.044","article-title":"Temperature measurements using a lithium niobate (LiNbO3) pyroelectric ceramic","volume":"75","author":"Sarker","year":"2015","journal-title":"Measurement"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.proeng.2012.09.200","article-title":"Flexible PVDF-TrFE pyroelectric sensor integrated on a fully printed p-channel organic transistor","volume":"47","author":"Maiolo","year":"2012","journal-title":"Procedia Eng."},{"key":"ref_17","unstructured":"Cardoso, V.F., Correia, R.G., Rocha, J.G., Lanceros-Mend\u00e9z, S., and Minas, G. (September, January 31). Design and fabrication of piezoelectric microactuators based on \u03b2-poly(vinylidene fluoride) films for microfluidic applications. Proceedings of the 32nd Annual International Conference of the IEEE EMBS, Buenos Aires, Argentina."},{"key":"ref_18","unstructured":"Pullano, S.A., Perozziello, G., Di Fabrizio, E., and Fiorillo, A.S. (2011, January 1\u20134). Pyroelectric PVDF transducer for temperature measurements in fluidic micro-channels. Proceedings of the E-Health and Bioengineering Conference (EHB), Iasi, Romania."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pullano, S.A., Fiorillo, A.S., and Islam, S.K. (2014, January 1\u20132). A pyroelectric sensor for system-on-a-chip. Proceedings of the 40th Annual Northeast Bioengineering Conference (NEBEC), Boston, MA, USA.","DOI":"10.1109\/NEBEC.2014.6972911"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1109\/JSEN.2014.2315738","article-title":"Pyroelectric Sensor for Monitoring the Temperature of Biological Fluids in Micro Channel Devices","volume":"14","author":"Pullano","year":"2014","journal-title":"IEEE Sens. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.sna.2015.07.008","article-title":"A new transduction mechanism for hydrophones employing piezoelectricity and a field-effect transistor","volume":"233","author":"Sung","year":"2015","journal-title":"Sen. Actuators A Phys."},{"key":"ref_22","first-page":"16849","article-title":"New crystal structure and discharge efficiency of poly(vinylidene fluoride-hexafluoropropylene)\/poly(methyl methacrylate) blend films","volume":"4","author":"Peng","year":"2014","journal-title":"RCS Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0920-5632(91)90049-K","article-title":"Low Noise Analog CMOS Signal Processor with a Large Dynamic Range for Silicon Calorimeters","volume":"23","author":"Beuville","year":"1991","journal-title":"Nucl. Phys. B Proc. Suppl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11265-008-0307-2","article-title":"An Electromechanical Film Sensor Based Wireless Ballistocardiographic Chair: Implementation and Performance","volume":"57","author":"Junnila","year":"2009","journal-title":"J. Signal Proc. Syst."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1118\/1.2975227","article-title":"Design and Feasibility of Active Matrix Flat Panel Detector Using Avalanche Amorphous Selenium for Protein Crystallography","volume":"35","author":"Sultana","year":"2008","journal-title":"Med. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.1039\/C5CP00218D","article-title":"Self-oriented \u03b2-crystalline phase in the polyvinylidene fluoride ferroelectric and piezo-sensitive ultrathin Langmuir-Schaefer film","volume":"17","author":"Maji","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.3390\/s130505478","article-title":"Flexible PZT Thin Film Tactile Sensor for Biomedical Monitoring","volume":"13","author":"Tseng","year":"2013","journal-title":"Sensors"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1063\/1.3663970","article-title":"Photopyroelectric calorimeter for the simultaneous thermal, optical, and structural characterization of samples over phase transitions","volume":"82","author":"Zammit","year":"2011","journal-title":"Rev. Sci. Instrum."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1063\/1.2062916","article-title":"Pyroelectricity: Form ancient curiosity to modern imaging tool","volume":"58","author":"Lang","year":"2005","journal-title":"Phys. Today"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.sna.2006.09.015","article-title":"Theoretical and experimental study of power radiometric measurements using a pyroelectric current integrator converter","volume":"135","author":"Touayar","year":"2006","journal-title":"Sens. Actuators A Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.infrared.2011.08.008","article-title":"Document Design and thermal analysis of electrically calibrated pyroelectric detector","volume":"55","author":"Shao","year":"2012","journal-title":"Infrared Phys. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1063\/1.1520314","article-title":"Current mode versus voltage mode measurement of signals from pyroelectric sensors","volume":"74","author":"Chirtoc","year":"2003","journal-title":"Rev. Sci. Instrum."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/B:ALOG.0000011161.44537.da","article-title":"Current Mode, Voltage Mode, or Free Mode? A Few Sage Suggestion","volume":"38","author":"Gilber","year":"2004","journal-title":"Analog Integr. Circuits Signal Proc."},{"key":"ref_34","unstructured":"Jung, W.G. (2004). Sensor Signal Conditioning. Op Amp Applications Handbook, Analog Device Series."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Martin, A.J., Massarotto, M., and Carlosena, A. (2009, January 25\u201328). Performance tradeoffs of integrated CMOS charge amplifiers. Proceedings of the IEEE Sensors 2009 Conference, Christchurch, New Zealand.","DOI":"10.1109\/ICSENS.2009.5398412"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"051101","DOI":"10.1063\/1.4709621","article-title":"Invited Review Article: Practical guide for pyroelectric measurements","volume":"83","author":"Lubomirsky","year":"2012","journal-title":"Rev. Sci. Instrum."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1063\/1.1626005","article-title":"Pyroelectric infrared sensor-based thermometer for monitoring indoor objects","volume":"74","author":"Tsai","year":"2003","journal-title":"Rev. Sci. Instrum."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1079-4042(09)04204-0","article-title":"Radiation Thermometer Designs, in: Radiometric Temperature Measurements","volume":"42","author":"Yoon","year":"2009","journal-title":"Exp. Methods Phys. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.sna.2011.05.003","article-title":"High-sensitive Pyroelectric detectors with internal thermal amplification","volume":"172","author":"Querner","year":"2011","journal-title":"Sens. Actuators A Phys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0960-1317\/25\/11\/115016","article-title":"Multi-sensitive temperature sensor platforms using aluminum nitride MEMS resonators","volume":"25","author":"Campanella","year":"2015","journal-title":"J. Micromech. Microeng."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"DeWitt, D.P., and Nutter, G.D. (1988). Theory and Practice of Radiation Thermometry, Wiley-Interscience.","DOI":"10.1002\/9780470172575"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0955-2219(98)00454-3","article-title":"Pyroelectric and sensor properties of ferroelectric thin films for energy conversion","volume":"19","author":"Buchanan","year":"1999","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.sna.2009.12.018","article-title":"Thermal energy harvesting through pyroelectricity","volume":"158","author":"Cuadras","year":"2010","journal-title":"Sens. Actuators A Phys."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ravindran, S.K.T., Huesgen, T., Kroener, M., and Woias, P. (2011, January 5\u20139). A Self-Sustaining Pyroelectric Energy Harvester Utilizing Spatial Thermal Gradients. Proceedings of the 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS\u201911, Beijing, China.","DOI":"10.1109\/TRANSDUCERS.2011.5969838"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0964-1726\/19\/6\/065018","article-title":"Laminate composites with enhanced pyroelectric effects for energy harvesting","volume":"19","author":"Chang","year":"2010","journal-title":"Smart Mater. Struct."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1109\/TUFFC.2011.1769","article-title":"Cyclic energy harvesting from pyroelectric materials","volume":"58","author":"Mane","year":"2011","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1109\/TUFFC.2008.680","article-title":"Pyroelectric energy conversion: Optimization principles","volume":"55","author":"Sebald","year":"2008","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_48","unstructured":"(2016, May 16). ADInstruments. Available online: http:\/\/m-cdn.adinstruments.com\/product-data-cards\/MLT1402-DCW-15A.pdf."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/4\/850\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:32:36Z","timestamp":1760207556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/4\/850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,4]]}},"alternative-id":["s17040850"],"URL":"https:\/\/doi.org\/10.3390\/s17040850","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}