{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:13:48Z","timestamp":1772079228813,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:00:00Z","timestamp":1494028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Nowadays, there is a strong demand for the development of new analytical devices with novel performances to improve the quality of our daily lives. In this context, multisensor systems such as electronic tongues (eTs) have emerged as promising alternatives. Recently, we have developed a new versatile eT system by coupling surface plasmon resonance imaging (SPRi) with cross-reactive sensor arrays. In order to largely simplify the preparation of sensing materials with a great diversity, an innovative combinatorial approach was proposed by combining and mixing a small number of easily accessible molecules displaying different physicochemical properties. The obtained eT was able to generate 2D continuous evolution profile (CEP) and 3D continuous evolution landscape (CEL), which is also called 3D image, with valuable kinetic information, for the discrimination and classification of samples. Here, diverse applications of such a versatile eT have been summarized. It is not only effective for pure protein analysis, capable of differentiating protein isoforms such as chemokines CXCL12\u03b1 and CXCL12\u03b3, but can also be generalized for the analysis of complex mixtures, such as milk samples, with promising potential for monitoring the deterioration of milk.<\/jats:p>","DOI":"10.3390\/s17051046","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T11:45:16Z","timestamp":1494243916000},"page":"1046","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays\u2014A Mini-Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Laurie-Amandine","family":"Gar\u00e7on","sequence":"first","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Institut N\u00e9el, F-38000 Grenoble, France"}]},{"given":"Maria","family":"Genua","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]},{"given":"Yanjie","family":"Hou","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-4305","authenticated-orcid":false,"given":"Arnaud","family":"Buhot","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]},{"given":"Roberto","family":"Calemczuk","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]},{"given":"Thierry","family":"Livache","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]},{"given":"Martial","family":"Billon","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]},{"given":"Christine","family":"Le Narvor","sequence":"additional","affiliation":[{"name":"ICMMO\/G2M\/LCOM, UMR 8182 (CNRS-UPS), LabEx LERMIT, Universit\u00e9 Paris-Sud 11, 91405 Orsay CEDEX, France"}]},{"given":"David","family":"Bonnaff\u00e9","sequence":"additional","affiliation":[{"name":"ICMMO\/G2M\/LCOM, UMR 8182 (CNRS-UPS), LabEx LERMIT, Universit\u00e9 Paris-Sud 11, 91405 Orsay CEDEX, France"}]},{"given":"Hugues","family":"Lortat-Jacob","sequence":"additional","affiliation":[{"name":"Institut de Biologie Structurale, University of Grenoble Alpes, UMR 5075, 38027 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, Institut de Biologie Structurale, UMR 5075, 38027 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Institut de Biologie Structurale, UMR 5075, 38027 Grenoble, France"}]},{"given":"Yanxia","family":"Hou","sequence":"additional","affiliation":[{"name":"Institut Nanosciences et Cryog\u00e9nie, University of Grenoble Alpes, INAC-SyMMES, F-38000 Grenoble, France"},{"name":"Centre National de la Recherche Scientifique, SyMMES UMR 5819, F-38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), INAC-SyMMES, F-38000 Grenoble, France"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lvova, L., Kirsanov, D., Di Natale, C., and Legin, A. 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