{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:27:08Z","timestamp":1762522028292,"version":"build-2065373602"},"reference-count":197,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Due to the recent demand for high-throughput cellular assays, a lot of efforts have been made on miniaturization of cell-based biosensors by preparing cell microarrays. Various microfabrication technologies have been used to generate cell microarrays, where cells of different phenotypes are immobilized either on a flat substrate (positional array) or on particles (solution or suspension array) to achieve multiplexed and high-throughput cell-based biosensing. After introducing the fabrication methods for preparation of the positional and suspension cell microarrays, this review discusses the applications of the cell microarray including toxicology, drug discovery and detection of toxic agents.<\/jats:p>","DOI":"10.3390\/s17061293","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T10:53:09Z","timestamp":1496746389000},"page":"1293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Cell Microarray Technologies for High-Throughput Cell-Based Biosensors"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-5166","authenticated-orcid":false,"given":"Hye","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea"}]},{"given":"Woong","family":"Koom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea"}]},{"given":"Won-Gun","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1021\/la503533g","article-title":"Biosensor regeneration: A review of common techniques and outcomes","volume":"31","author":"Goode","year":"2014","journal-title":"Langmuir"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1039\/C6LC00831C","article-title":"Multiplex cell microarrays for high-throughput screening","volume":"16","author":"Berthuy","year":"2016","journal-title":"Lab Chip"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1114\/1.225","article-title":"Development and application of cell-based biosensors","volume":"27","author":"Pancrazio","year":"1999","journal-title":"Ann. 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