{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:01:54Z","timestamp":1778749314833,"version":"3.51.4"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this study, we prepared adenosine triphosphate (ATP) encapsulated liposomes, and assessed their applicability for the surface enhanced Raman scattering (SERS)-based assays with gold-silver alloy (Au@Ag)-assembled silica nanoparticles (NPs; SiO2@Au@Ag). The liposomes were prepared by the thin film hydration method from a mixture of l-\u03b1-phosphatidylcholine, cholesterol, and PE-PEG2000 in chloroform; evaporating the solvent, followed by hydration of the resulting thin film with ATP in phosphate-buffered saline (PBS). Upon lysis of the liposome, the SERS intensity of the SiO2@Au@Ag NPs increased with the logarithm of number of ATP-encapsulated liposomes after lysis in the range of 8 \u00d7 106 to 8 \u00d7 1010. The detection limit of liposome was calculated to be 1.3 \u00d7 10\u221217 mol. The successful application of ATP-encapsulated liposomes to SiO2@Au@Ag NPs based SERS analysis has opened a new avenue for Raman label chemical (RCL)-encapsulated liposome-enhanced SERS-based immunoassays.<\/jats:p>","DOI":"10.3390\/s17071480","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T08:16:18Z","timestamp":1498205778000},"page":"1480","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adenosine Triphosphate-Encapsulated Liposomes with Plasmonic Nanoparticles for Surface Enhanced Raman Scattering-Based Immunoassays"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-7102","authenticated-orcid":false,"given":"Xuan-Hung","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunil","family":"Hahm","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Education, Seoul National University, Seoul 151-742, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-7946","authenticated-orcid":false,"given":"Bong-Hyun","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Smolsky, J., Kaur, S., Hayashi, C., Batra, S., and Krasnoslobodtsev, A. 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