{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:12:47Z","timestamp":1760242367032,"version":"build-2065373602"},"reference-count":115,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-CRP10-2012-07","NRF2015NRF-POC0001-19"],"award-info":[{"award-number":["NRF-CRP10-2012-07","NRF2015NRF-POC0001-19"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The integration of supported lipid membranes with surface-based nanoplasmonic arrays provides a powerful sensing approach to investigate biointerfacial phenomena at membrane interfaces. While a growing number of lipid vesicles, protein, and nucleic acid systems have been explored with nanoplasmonic sensors, there has been only very limited investigation of the interactions between solution-phase nanomaterials and supported lipid membranes. Herein, we established a surface-based localized surface plasmon resonance (LSPR) sensing platform for probing the interaction of dielectric nanoparticles with supported lipid bilayer (SLB)-coated, plasmonic nanodisk arrays. A key emphasis was placed on controlling membrane functionality by tuning the membrane surface charge vis-\u00e0-vis lipid composition. The optical sensing properties of the bare and SLB-coated sensor surfaces were quantitatively compared, and provided an experimental approach to evaluate nanoparticle\u2013membrane interactions across different SLB platforms. While the interaction of negatively-charged silica nanoparticles (SiNPs) with a zwitterionic SLB resulted in monotonic adsorption, a stronger interaction with a positively-charged SLB resulted in adsorption and lipid transfer from the SLB to the SiNP surface, in turn influencing the LSPR measurement responses based on the changing spatial proximity of transferred lipids relative to the sensor surface. Precoating SiNPs with bovine serum albumin (BSA) suppressed lipid transfer, resulting in monotonic adsorption onto both zwitterionic and positively-charged SLBs. Collectively, our findings contribute a quantitative understanding of how supported lipid membrane coatings influence the sensing performance of nanoplasmonic arrays, and demonstrate how the high surface sensitivity of nanoplasmonic sensors is well-suited for detecting the complex interactions between nanoparticles and lipid membranes.<\/jats:p>","DOI":"10.3390\/s17071484","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:05:25Z","timestamp":1498212325000},"page":"1484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Probing the Interaction of Dielectric Nanoparticles with Supported Lipid Membrane Coatings on Nanoplasmonic Arrays"],"prefix":"10.3390","volume":"17","author":[{"given":"Abdul","family":"Ferhan","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamaliel","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Jackman","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tun","family":"Sut","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Park","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-8955","authenticated-orcid":false,"given":"Nam-Joon","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering and Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore"},{"name":"School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/smll.201501914","article-title":"Plasmonic nanohole sensor for capturing single virus-like particles toward virucidal drug evaluation","volume":"12","author":"Jackman","year":"2016","journal-title":"Small"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1021\/nl103025u","article-title":"An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media","volume":"10","author":"Yanik","year":"2010","journal-title":"Nano Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acsinfecdis.6b00063","article-title":"New approaches for virus detection through multidisciplinary partnerships","volume":"2","author":"Fawcett","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nbt.2886","article-title":"Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor","volume":"32","author":"Im","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Liang, K., Liu, F., Fan, J., Sun, D., Liu, C., Lyon, C.J., Bernard, D.W., Li, Y., Yokoi, K., and Katz, M.H. (2017). Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring. Nat. Biomed. Eng., 1.","DOI":"10.1038\/s41551-016-0021"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1586\/14737159.2015.1041378","article-title":"Nano-plasmonic exosome diagnostics","volume":"15","author":"Im","year":"2015","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1021\/acsnano.5b08081","article-title":"Trapping and detection of nanoparticles and cells using a parallel photonic nanojet array","volume":"10","author":"Li","year":"2016","journal-title":"ACS Nano"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhi, Y., Yu, X.-C., Gong, Q., Yang, L., and Xiao, Y.-F. (2017). Single nanoparticle detection using optical microcavities. Adv. Mater., 29.","DOI":"10.1002\/adma.201604920"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1039\/c2lc40455a","article-title":"Real-time full-spectral imaging and affinity measurements from 50 microfluidic channels using nanohole surface plasmon resonance","volume":"12","author":"Lee","year":"2012","journal-title":"Lab Chip."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1039\/c0sc00365d","article-title":"Membrane protein biosensing with plasmonic nanopore arrays and pore-spanning lipid membranes","volume":"1","author":"Im","year":"2010","journal-title":"Chem. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1021\/nn202554t","article-title":"Facile assembly of micro-and nanoarrays for sensing with natural cell membranes","volume":"5","author":"Wittenberg","year":"2011","journal-title":"ACS Nano"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: Where they are and how they behave","volume":"9","author":"Voelker","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature13474","article-title":"Lipid landscapes and pipelines in membrane homeostasis","volume":"510","author":"Holthuis","year":"2014","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1002\/smll.201400518","article-title":"Controlling lipid membrane architecture for tunable nanoplasmonic biosensing","volume":"10","author":"Zan","year":"2014","journal-title":"Small"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"020801-1","DOI":"10.1116\/1.4944830","article-title":"Understanding the formation of supported lipid bilayers via vesicle fusion\u2014A case that exemplifies the need for the complementary method approach (Review)","volume":"11","author":"Lind","year":"2016","journal-title":"Biointerphases"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1021\/la104348f","article-title":"pH-driven assembly of various supported lipid platforms: A comparative study on silicon oxide and titanium oxide","volume":"27","author":"Cho","year":"2011","journal-title":"Langmuir"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1021\/am507651h","article-title":"Self-assembly formation of lipid bilayer coatings on bare aluminum oxide: Overcoming the force of interfacial water","volume":"7","author":"Jackman","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1529\/biophysj.104.053728","article-title":"Following the formation of supported lipid bilayers on mica: A study combining AFM, QCM-D, and ellipsometry","volume":"88","author":"Richter","year":"2005","journal-title":"Biophys. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1016\/S0006-3495(03)74722-5","article-title":"Pathways of lipid vesicle deposition on solid surfaces: A combined QCM-D and AFM study","volume":"85","author":"Richter","year":"2003","journal-title":"Biophys. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/la0263920","article-title":"Intact vesicle adsorption and supported biomembrane formation from vesicles in solution:\u2009 Influence of surface chemistry, vesicle size, temperature, and osmotic pressure","volume":"19","author":"Reimhult","year":"2003","journal-title":"Langmuir"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chemphyslip.2006.02.010","article-title":"Surface plasmon resonance in protein\u2013membrane interactions","volume":"141","author":"Lakey","year":"2006","journal-title":"Chem. Phys. Lipids"},{"key":"ref_22","unstructured":"Kleinschmidt, J.H. (2013). Surface Plasmon resonance for measuring interactions of proteins with lipid membranes. Lipid-Protein Interactions: Methods and Protocols, Humana Press."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1021\/la7014308","article-title":"Effect of adsorbed layer surface roughness on the QCM-D response: Focus on trapped water","volume":"23","author":"Macakova","year":"2007","journal-title":"Langmuir"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1021\/jp4038528","article-title":"Protein adsorption at nanopatterned surfaces studied by quartz crystal microbalance with dissipation and surface plasmon resonance","volume":"117","author":"Kristensen","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10642","DOI":"10.1021\/acs.analchem.5b03572","article-title":"Ordered structures of functionalized silica nanoparticles on gold surfaces: Correlation of quartz crystal microbalance with structural characterization","volume":"87","author":"Grunewald","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1515\/nanoph-2012-0026","article-title":"Promises and challenges of nanoplasmonic devices for refractometric biosensing","volume":"2","author":"Dahlin","year":"2013","journal-title":"Nanophotonics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1039\/C6CS00494F","article-title":"Nanoplasmonic sensors for biointerfacial science","volume":"46","author":"Jackman","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1515\/nanoph-2016-0101","article-title":"Recent advances in nanoplasmonic biosensors: Applications and lab-on-a-chip integration","volume":"Volume 6","author":"Estevez","year":"2017","journal-title":"Nanophotonics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.aca.2013.10.048","article-title":"Trends and challenges of refractometric nanoplasmonic biosensors: A review","volume":"806","author":"Estevez","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1039\/C4AN02258K","article-title":"Sensing applications based on plasmonic nanopores: The hole story","volume":"140","author":"Dahlin","year":"2015","journal-title":"Analyst"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1021\/cr100313v","article-title":"Localized surface plasmon resonance sensors","volume":"111","author":"Mayer","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.physchem.58.032806.104607","article-title":"Localized surface plasmon resonance spectroscopy and sensing","volume":"58","author":"Willets","year":"2007","journal-title":"Annu. Rev. Phys. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1021\/nl034372s","article-title":"Single silver nanoparticles as real-time optical sensors with zeptomole sensitivity","volume":"3","author":"McFarland","year":"2003","journal-title":"Nano Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1021\/acs.nanolett.6b04124","article-title":"Single particle nanoplasmonic sensing in individual nanofluidic channels","volume":"16","author":"Fritzsche","year":"2016","journal-title":"Nano Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1039\/C6AN02384C","article-title":"Analytical methods based on the light-scattering of plasmonic nanoparticles at the single particle level with dark-field microscopy imaging","volume":"142","author":"Li","year":"2017","journal-title":"Analyst"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1021\/jz200482f","article-title":"Improved sensitivity of localized surface plasmon resonance transducers using reflection measurements","volume":"2","author":"Kedem","year":"2011","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1364\/BOE.2.000478","article-title":"A reflection-based localized surface plasmon resonance fiber-optic probe for biochemical sensing","volume":"2","author":"Lin","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nmat2162","article-title":"Biosensing with plasmonic nanosensors","volume":"7","author":"Anker","year":"2008","journal-title":"Nat. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1126\/science.aaa6805","article-title":"Nanoplasmonic sensing and detection","volume":"348","author":"Stockman","year":"2015","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3390\/s150101635","article-title":"Design of surface modifications for nanoscale sensor applications","volume":"15","author":"Reimhult","year":"2015","journal-title":"Sensors"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/nmeth.2211","article-title":"Membrane-protein binding measured with solution-phase plasmonic nanocube sensors","volume":"9","author":"Wu","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1021\/acs.bioconjchem.6b00569","article-title":"Biointerfacing and applications of cell membrane-coated nanoparticles","volume":"28","author":"Kroll","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1021\/nl900513k","article-title":"A nanocube plasmonic sensor for molecular binding on membrane surfaces","volume":"9","author":"Galush","year":"2009","journal-title":"Nano Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"26725","DOI":"10.1021\/jp406013q","article-title":"Using the localized surface plasmon resonance of gold nanoparticles to monitor lipid membrane assembly and protein binding","volume":"117","author":"Messersmith","year":"2013","journal-title":"J. Phys. Chem. C"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1021\/nl101727b","article-title":"Indirect nanoplasmonic sensing: Ultrasensitive experimental platform for nanomaterials science and optical nanocalorimetry","volume":"10","author":"Langhammer","year":"2010","journal-title":"Nano Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125105","DOI":"10.1063\/1.3265321","article-title":"A combined nanoplasmonic and electrodeless quartz crystal microbalance setup","volume":"80","author":"Larsson","year":"2009","journal-title":"Rev. Sci. Instrum."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1002\/adfm.201202214","article-title":"Topographically flat substrates with embedded nanoplasmonic devices for biosensing","volume":"23","author":"Jose","year":"2013","journal-title":"Adv. Funct. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/acssensors.6b00612","article-title":"Topographically flat nanoplasmonic sensor chips for biosensing and materials science","volume":"2","author":"Nugroho","year":"2017","journal-title":"ACS Sens."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12524","DOI":"10.1021\/acs.analchem.6b04303","article-title":"Integration of quartz crystal microbalance-dissipation and reflection-mode localized surface plasmon resonance sensors for biomacromolecular interaction analysis","volume":"88","author":"Ferhan","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1021\/ja043672o","article-title":"Localized surface plasmon resonance sensing of lipid-membrane-mediated biorecognition events","volume":"127","author":"Dahlin","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1021\/nl072006t","article-title":"Supported lipid bilayer formation and lipid-membrane-mediated biorecognition reactions studied with a new nanoplasmonic sensor template","volume":"7","author":"Jonsson","year":"2007","journal-title":"Nano Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7988","DOI":"10.1021\/ac8008753","article-title":"Simultaneous nanoplasmonic and quartz crystal microbalance sensing: Analysis of biomolecular conformational changes and quantification of the bound molecular mass","volume":"80","author":"Jonsson","year":"2008","journal-title":"Anal. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1021\/acs.analchem.6b00801","article-title":"Ultrasensitive plasmonic platform for label-free detection of membrane-associated species","volume":"88","author":"Bruzas","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1021\/ac300819a","article-title":"High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance","volume":"84","author":"Wittenberg","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15080","DOI":"10.1039\/C5NR04208A","article-title":"Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature","volume":"7","author":"Junesch","year":"2015","journal-title":"Nanoscale"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1021\/acs.langmuir.6b00439","article-title":"Influence of divalent cations on deformation and rupture of adsorbed lipid vesicles","volume":"32","author":"Dacic","year":"2016","journal-title":"Langmuir"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1039\/C6CP07930J","article-title":"Investigating how vesicle size influences vesicle adsorption on titanium oxide: a competition between steric packing and shape deformation","volume":"19","author":"Ferhan","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1039\/C5CC06861D","article-title":"Nanoplasmonic ruler to measure lipid vesicle deformation","volume":"52","author":"Jackman","year":"2016","journal-title":"Chem. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/acs.analchem.6b02532","article-title":"Quantitative profiling of nanoscale liposome deformation by a localized surface plasmon resonance sensor","volume":"89","author":"Jackman","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9494","DOI":"10.1021\/la502431x","article-title":"Nanoplasmonic biosensing for soft matter adsorption: kinetics of lipid vesicle attachment and shape deformation","volume":"30","author":"Jackman","year":"2014","journal-title":"Langmuir"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1021\/la504267g","article-title":"Contribution of temperature to deformation of adsorbed vesicles studied by nanoplasmonic biosensing","volume":"31","author":"Oh","year":"2015","journal-title":"Langmuir"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1021\/acs.langmuir.5b03239","article-title":"Graphene oxide and lipid membranes: size-dependent interactions","volume":"32","author":"Frost","year":"2016","journal-title":"Langmuir"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1021\/acs.langmuir.6b04359","article-title":"Unraveling interactions between ionic liquids and phospholipid vesicles using nanoplasmonic sensing","volume":"33","author":"Witos","year":"2017","journal-title":"Langmuir"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1039\/C5NR07954C","article-title":"The relevance of membrane models to understand nanoparticles-cell membrane interactions","volume":"8","author":"Rascol","year":"2016","journal-title":"Nanoscale"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nmat2442","article-title":"Understanding biophysicochemical interactions at the nano-bio interface","volume":"8","author":"Nel","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1039\/c2sm06999g","article-title":"Beyond the lipid-bilayer: Interaction of polymers and nanoparticles with membranes","volume":"8","author":"Schulz","year":"2012","journal-title":"Soft Matter"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1021\/es403864v","article-title":"Nanoparticles meet cell membranes: probing nonspecific interactions using model membranes","volume":"48","author":"Chen","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0955-0674(00)00191-5","article-title":"Subcellular targeting by membrane lipids","volume":"13","author":"Hurley","year":"2001","journal-title":"Curr. Opin. Cell. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)81560-3","article-title":"Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion","volume":"100","author":"Raucher","year":"2000","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrm4080","article-title":"The systematic analysis of protein-lipid interactions comes of age","volume":"16","author":"Saliba","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3109\/09687688.2012.700490","article-title":"Model membrane platforms to study protein-membrane interactions","volume":"29","author":"Sezgin","year":"2012","journal-title":"Mol. Membr. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature04164","article-title":"Polymer-supported membranes as models of the cell surface","volume":"437","author":"Tanaka","year":"2005","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11352","DOI":"10.3390\/s101211352","article-title":"Sensing-applications of surface-based single vesicle arrays","volume":"10","author":"Christensen","year":"2010","journal-title":"Sensors"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.surfrep.2006.06.001","article-title":"Solid supported lipid bilayers: From biophysical studies to sensor design","volume":"61","author":"Castellana","year":"2006","journal-title":"Surf. Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10920","DOI":"10.1021\/la2019132","article-title":"Formation of nanopore-spanning lipid bilayers through liposome fusion","volume":"27","author":"Kumar","year":"2011","journal-title":"Langmuir"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/nl048153y","article-title":"The formation of supported lipid bilayers on silica nanoparticles revealed by cryoelectron microscopy","volume":"5","author":"Mornet","year":"2005","journal-title":"Nano Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1109\/TNB.2011.2166086","article-title":"Supported lipid bilayers with controlled curvature via colloidal lithography","volume":"10","author":"Sundh","year":"2011","journal-title":"IEEE Trans. NanoBiosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7838","DOI":"10.1021\/jp2025363","article-title":"Formation of supported lipid bilayers at surfaces with controlled curvatures: Influence of lipid charge","volume":"115","author":"Sundh","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/1439-7641(20021018)3:10<885::AID-CPHC885>3.0.CO;2-9","article-title":"Membrane-suspended nanocompartments based on ordered pores in alumina","volume":"3","author":"Hennesthal","year":"2002","journal-title":"Chem. Phys. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jcis.2011.09.067","article-title":"Phospholipids as an alternative to direct covalent coupling: Surface functionalization of nanoporous alumina for protein recognition and purification","volume":"366","author":"Lazzara","year":"2012","journal-title":"J. Colloid Interface Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12006","DOI":"10.1038\/srep12006","article-title":"Resolving single membrane fusion events on planar pore-spanning membranes","volume":"5","author":"Schwenen","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"91102","DOI":"10.1039\/C6RA05693H","article-title":"TiO2 nanoparticle interactions with supported lipid membranes\u2014an example of removal of membrane patches","volume":"6","author":"Zhao","year":"2016","journal-title":"RSC Adv."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bpc.2015.05.006","article-title":"Size dependence of gold nanoparticle interactions with a supported lipid bilayer: A QCM-D study","volume":"203\u2013204","author":"Bailey","year":"2015","journal-title":"Biophys. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"15547","DOI":"10.1039\/C4CP05882H","article-title":"Native silica nanoparticles are powerful membrane disruptors","volume":"17","author":"Alkhammash","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1021\/acsnano.6b04160","article-title":"Nonspecific colloidal-type interaction explains size-dependent specific binding of membrane-targeted nanoparticles","volume":"10","author":"Lundgren","year":"2016","journal-title":"ACS Nano"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1021\/acs.est.5b04694","article-title":"Influence of solution chemistry and soft protein coronas on the interactions of silver nanoparticles with model biological membranes","volume":"50","author":"Wang","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1039\/C4NR06892K","article-title":"Nanoparticle-lipid bilayer interactions studied with lipid bilayer arrays","volume":"7","author":"Lu","year":"2015","journal-title":"Nanoscale"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"21399","DOI":"10.1021\/acs.jpcc.6b05460","article-title":"Structural changes to lipid bilayers and their surrounding water upon interaction with functionalized gold nanoparticles","volume":"120","author":"Lis","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jp512107z","article-title":"Direct probes of 4 nm diameter gold nanoparticles interacting with supported lipid bilayers","volume":"119","author":"Troiano","year":"2015","journal-title":"J. Phys. Chem. C"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1002\/adma.200700680","article-title":"Hole\u2013mask colloidal lithography","volume":"19","author":"Fredriksson","year":"2007","journal-title":"Adv. Mater."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1021\/ac0601967","article-title":"Improving the instrumental resolution of sensors based on localized surface plasmon resonance","volume":"78","author":"Dahlin","year":"2006","journal-title":"Anal. Chem."},{"key":"ref_92","first-page":"95","article-title":"Supported planar membranes in studies of cell-cell recognition in the immune system","volume":"864","author":"McConnell","year":"1986","journal-title":"BBA Rev. Biomembr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1021\/la903117x","article-title":"Interfacial binding dynamics of bee venom phospholipase A2 investigated by dynamic light scattering and quartz crystal microbalance","volume":"26","author":"Jackman","year":"2010","journal-title":"Langmuir"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1021\/acs.analchem.7b00370","article-title":"Probing spatial proximity of supported lipid bilayers to silica surfaces by localized surface plasmon resonance sensing","volume":"89","author":"Ferhan","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nprot.2010.65","article-title":"Quartz crystal microbalance with dissipation monitoring of supported lipid bilayers on various substrates","volume":"5","author":"Cho","year":"2010","journal-title":"Nat. Protoc."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1021\/js990006q","article-title":"O-ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serum-compatible DNA transfection agent","volume":"88","author":"MacDonald","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1529\/biophysj.103.036681","article-title":"Investigation of temperature-induced phase transitions in DOPC and DPPC phospholipid bilayers using temperature-controlled scanning force microscopy","volume":"86","author":"Leonenko","year":"2004","journal-title":"Biophys. J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.3390\/ijms14023514","article-title":"Preparation of DOPC and DPPC supported planar lipid bilayers for atomic force microscopy and atomic force spectroscopy","volume":"14","author":"Attwood","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1109\/JPROC.2016.2624340","article-title":"Optical biosensors based on plasmonic nanostructures: A review","volume":"104","author":"Wrobel","year":"2016","journal-title":"Proc. IEEE"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1021\/jp983996x","article-title":"Formation and spreading of lipid bilayers on planar glass supports","volume":"103","author":"Cremer","year":"1999","journal-title":"J. Phys. Chem. B"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1021\/jp014337e","article-title":"Electrical properties of supported lipid bilayer membranes","volume":"106","author":"Wiegand","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1021\/la900181c","article-title":"Formation of supported bilayers on silica substrates","volume":"25","author":"Anderson","year":"2009","journal-title":"Langmuir"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1021\/jp0361327","article-title":"A nanoscale optical biosensor: The long range distance dependence of the localized surface plasmon resonance of noble metal nanoparticles","volume":"108","author":"Haes","year":"2004","journal-title":"J. Phys. Chem. B"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"20522","DOI":"10.1021\/jp0540656","article-title":"Localized surface plasmon resonance nanosensor: A high-resolution distance-dependence study using atomic layer deposition","volume":"109","author":"Whitney","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/cr068107d","article-title":"Surface plasmon resonance sensors for detection of chemical and biological species","volume":"108","author":"Homola","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/polb.1995.090330911","article-title":"Metal particle adsorption and diffusion in a model polymer\/metal composite system","volume":"33","author":"Shull","year":"1995","journal-title":"J. Polym. Sci. Pol. Phys."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"17396","DOI":"10.1021\/la303300b","article-title":"Surface charge dependent nanoparticle disruption and deposition of lipid bilayer assemblies","volume":"28","author":"Xiao","year":"2012","journal-title":"Langmuir"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1021\/ja2040305","article-title":"Disruption of supported lipid bilayers by semihydrophobic nanoparticles","volume":"133","author":"Jing","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Melby, E.S., Lohse, S.E., Park, J.E., Vartanian, A.M., Putans, R.A., Abbott, H.B., Hamers, R.J., Murphy, C.J., and Pedersen, J.A. (2017). Cascading effects of nanoparticle coatings: Surface functionalization dictates the assemblage of complexed proteins and subsequent interaction with model cell membranes. ACS Nano.","DOI":"10.1021\/acsnano.7b00231"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1021\/acsnano.6b05409","article-title":"Stealth immune properties of graphene oxide enabled by surface-bound complement factor H","volume":"10","author":"Belling","year":"2016","journal-title":"ACS Nano"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.1039\/C5CS00217F","article-title":"The nanoparticle biomolecule corona: Lessons learned-challenge accepted?","volume":"44","author":"Docter","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"26493","DOI":"10.1021\/acs.jpcc.5b07764","article-title":"Effect of silica surface properties on the formation of multilayer or submonolayer protein hard corona: Albumin adsorption on pyrolytic and colloidal SiO2 nanoparticles","volume":"119","author":"Catalano","year":"2015","journal-title":"J. Phys. Chem. C"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s10973-014-4300-7","article-title":"Adsorption and thermal properties of the bovine serum albumin-silicon dioxide system","volume":"120","author":"Sternik","year":"2015","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1021\/ja309812z","article-title":"Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency","volume":"135","author":"Lesniak","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cplett.2006.12.068","article-title":"Effective charge of bovine serum albumin determined by electrophoresis NMR","volume":"435","author":"Scheler","year":"2007","journal-title":"Chem. Phys. Lett."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/7\/1484\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:40:13Z","timestamp":1760208013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/7\/1484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,23]]},"references-count":115,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["s17071484"],"URL":"https:\/\/doi.org\/10.3390\/s17071484","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2017,6,23]]}}}