{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:42:21Z","timestamp":1765039341743,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Here, we propose simple diamond functionalization by carboxyl termination for adenosine triphosphate (ATP) detection by an aptamer. The high-sensitivity label-free aptamer sensor for ATP detection was fabricated on nanocrystalline diamond (NCD). Carboxyl termination of the NCD surface by vacuum ultraviolet excimer laser and fluorine termination of the background region as a passivated layer were investigated by X-ray photoelectron spectroscopy. Single strand DNA (amide modification) was used as the supporting biomolecule to immobilize into the diamond surface via carboxyl termination and become a double strand with aptamer. ATP detection by aptamer was observed as a 66% fluorescence signal intensity decrease of the hybridization intensity signal. The sensor operation was also investigated by the field-effect characteristics. The shift of the drain current\u2013drain voltage characteristics was used as the indicator for detection of ATP. From the field-effect characteristics, the shift of the drain current\u2013drain voltage was observed in the negative direction. The negative charge direction shows that the aptamer is capable of detecting ATP. The ability of the sensor to detect ATP was investigated by fabricating a field-effect transistor on the modified NCD surface.<\/jats:p>","DOI":"10.3390\/s17071686","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T10:45:48Z","timestamp":1500633948000},"page":"1686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aptamer-Based Carboxyl-Terminated Nanocrystalline Diamond Sensing Arrays for Adenosine Triphosphate Detection"],"prefix":"10.3390","volume":"17","author":[{"given":"Evi","family":"Suaebah","sequence":"first","affiliation":[{"name":"Department of Nanoscience and Nanoengineering, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Naramura","sequence":"additional","affiliation":[{"name":"Department of Nanoscience and Nanoengineering, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Myodo","sequence":"additional","affiliation":[{"name":"Department of Nanoscience and Nanoengineering, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Technology Research Association for Single Wall Carbon Nanotube (TASC), 1-1-1 Higashi, Tsukuba 305-8565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Nanoscience and Nanoengineering, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge J.","family":"Buendia","sequence":"additional","affiliation":[{"name":"Department of Nanoscience and Nanoengineering, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawarada","sequence":"additional","affiliation":[{"name":"Department of Nanoscience and Nanoengineering, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8555, Japan"},{"name":"Kagami Memorial Research Institute for Material Science and Technology, Shinjuku-ku, Tokyo 169-0051, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00216-005-3388-9","article-title":"FluMag-SELEX as an advantageous method for DNA aptamer selection","volume":"383","author":"Stoltenburg","year":"2005","journal-title":"Anal. 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