{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:21:55Z","timestamp":1771302115209,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T00:00:00Z","timestamp":1506211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Electrochemical dissolution of metallic copper into slightly acidic aqueous solutions of chitosan yields a clear and stable dispersion of Copper Oxide nanoparticles into the organic polymer host. The electrochemically synthesized chitosan:CuOx nanocomposite is characterized by means of spectrophotometry, frequency domain electrical measurements and morphological analysis. Solid state electrochemical cells having pure chitosan as the electrolyte and using chitosan:CuOx as the electrode, are developed and characterized by means of electrical measurements performed in the \u00b11 V voltage window. The current-voltage loops of the cells, measured in deionized water, are found to reversibly change in response to hydrogen peroxide added to the water in 0.2 \u03bcM subsequent steps. Such changes, clearly distinguishable from changes recorded in response to other analytes, can be exploited in order to develop a hydrogen peroxide sensor able to work without the need for any supporting electrolyte.<\/jats:p>","DOI":"10.3390\/s17102198","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T04:28:01Z","timestamp":1506400081000},"page":"2198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Copper Oxide Chitosan Nanocomposite: Characterization and Application in Non-Enzymatic Hydrogen Peroxide Sensing"],"prefix":"10.3390","volume":"17","author":[{"given":"Antonella","family":"Arena","sequence":"first","affiliation":[{"name":"Department of Engineering, Messina University, Messina 98166, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-0206","authenticated-orcid":false,"given":"Graziella","family":"Scandurra","sequence":"additional","affiliation":[{"name":"Department of Engineering, Messina University, Messina 98166, Italy"}]},{"given":"Carmine","family":"Ciofi","sequence":"additional","affiliation":[{"name":"Department of Engineering, Messina University, Messina 98166, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.progpolymsci.2010.12.005","article-title":"Organic-inorganic nanocomposite polymer electrolyte membranes for fuel cell applications","volume":"36","author":"Tripathi","year":"2011","journal-title":"Prog. Polym. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1388-2481(03)00010-9","article-title":"Hybrid organic-inorganic nanocomposite materials for application in solid state electrochemical supercapacitors","volume":"5","author":"Romero","year":"2003","journal-title":"Electrochem. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.3390\/ma7042747","article-title":"Hybrid Organic\/Inorganic Nanocomposites for Photovoltaic Cells","volume":"7","author":"Liu","year":"2014","journal-title":"Materials"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1039\/b706547g","article-title":"Hybrid polymer\u2013metal oxide thin films for photovoltaic applications","volume":"17","author":"Ravirajan","year":"2007","journal-title":"J. Mater. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Grover, R., Nanda, O., Gupta, N., and Saxena, K. (2015). Hydrogen peroxide sensing properties of PVA\/TiO2\/I2 nanocomposite-based free standing membranes. J. Appl. Polym. Sci., 132.","DOI":"10.1002\/app.42257"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.snb.2013.03.042","article-title":"Organic\/inorganic hybrid sensors: A review","volume":"182","author":"Wang","year":"2013","journal-title":"Sens. Actuators Chem. B"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.carbpol.2007.07.036","article-title":"Studies on the photocatalytic performance of cuprous oxide\/chitosan nanocomposite activated by visible light","volume":"72","author":"Chen","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Guibal, E., Quignard, F., and SenGupta, A.K. (2012). Polymer-supported metals and metal oxide nanoparticles: Synthesis, characterization, and applications. J. Nanopart. Res., 14.","DOI":"10.1007\/s11051-011-0715-2"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.eurpolymj.2012.12.009","article-title":"Chitosan-based biomaterials for tissue engineering","volume":"49","author":"Croisier","year":"2013","journal-title":"Eur. Polym. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/S0142-9612(00)00126-5","article-title":"Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: A review","volume":"21","author":"Matthew","year":"2000","journal-title":"Biomaterials"},{"key":"ref_11","first-page":"94","article-title":"Electrochemical Synthesis of New Silver-Chitosan\/Polyvinyl Alcohol Hybrid Nanoparticles and Evaluation of Their Antibacterial Activities","volume":"2","author":"Salih","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cben.201400025","article-title":"A Review on Chitin and Chitosan Polymers: Structure, Chemistry, Solubility, Derivatives, and Applications","volume":"2","author":"Zargar","year":"2015","journal-title":"ChemBioEng Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0043-1354(99)00291-2","article-title":"Treatment of waste water from distilleries with chitosan","volume":"34","author":"Lalov","year":"2000","journal-title":"Water Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.jprot.2007.11.005","article-title":"Preparation of chitosan particles suitable for enzyme immobilization","volume":"70","author":"Sisak","year":"2008","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1109\/JSEN.2011.2111367","article-title":"An Optical Fiber H2O2-Sensing Probe Using a Titanium(IV) Oxyacetylacetonate Immobilized Nafion Coating on an Bent Optical Fiber Probe","volume":"11","author":"Hu","year":"2011","journal-title":"IEEE Sens. J."},{"key":"ref_16","first-page":"56","article-title":"Development of the Biopolymeric Optical Planar Waveguide with Nanopattern","volume":"1","author":"Yoon","year":"2011","journal-title":"J. Surf. Eng. Mater. Adv. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1109\/JSEN.2012.2235311","article-title":"Utilization of Chitosan-Based Sensor Thin Films for the Detection of Lead Ion by Surface Plasmon Resonance Optical Sensor","volume":"13","author":"Fen","year":"2013","journal-title":"IEEE Sens. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.snb.2012.11.063","article-title":"The sensing mechanism and detection of low concentration acetone using chitosan-based sensors","volume":"177","author":"Nasution","year":"2013","journal-title":"Sens. Actuators Chem. B"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1021\/bm060416q","article-title":"Effect of Changes in Relative Humidity and Temperature on Ultrathin Chitosan Films","volume":"12","author":"Murray","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.bios.2015.11.005","article-title":"Electrochemical lactate biosensor based upon chitosan\/carbon nanotubes modified screen-printed graphite electrodes for the determination of lactate in embryonic cell cultures","volume":"77","author":"Montiel","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bios.2009.09.004","article-title":"Glucose-Oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing","volume":"25","author":"Kang","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1567-5394(01)00174-8","article-title":"Highly sensitive sensors based on the immobilization of tyrosinase in chitosan","volume":"57","author":"Wang","year":"2002","journal-title":"Bioelectrochemistry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.talanta.2015.06.020","article-title":"Fabrication of electrochemical sensor for paracetamol based on multi-walled carbon nanotubes and chitosan\u2013copper complex by self-assembly technique","volume":"144","author":"Mao","year":"2015","journal-title":"Talanta."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.msec.2015.07.049","article-title":"Construction of a sensitive and selective sensor for morphine using chitosan coated Fe3O4 magnetic nanoparticle as a modifier","volume":"58","author":"Dehdashtian","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.foodcont.2015.07.009","article-title":"Electrochemical sensor based rapid determination of melamine using ionic liquid\/zinc oxide nanoparticles\/chitosan\/gold electrode","volume":"59","author":"Rovina","year":"2016","journal-title":"Food Cont."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/s5040266","article-title":"A Biosensor Based on Immobilization of Horseradish Peroxidase in Chitosan Matrix Cross-linked with Glyoxal for Amperometric Determination of Hydrogen Peroxide","volume":"5","author":"Wang","year":"2005","journal-title":"Sensors"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF03353657","article-title":"Development of an Amperometric Hydrogen Peroxide Biosensor based on the Immobilization of Horseradish Peroxidase onto Nickel Ferrite Nanoparticle-Chitosan Composite","volume":"3","author":"Baykal","year":"2011","journal-title":"Nano-Micro Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1039\/C5AY02976G","article-title":"A sensitive enzyme-free hydrogen peroxide sensor based on a chitosan\u2013graphene quantum dot\/silver nanocube nanocomposite modified electrode","volume":"8","author":"Jiang","year":"2016","journal-title":"Anal. Methods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.snb.2014.01.043","article-title":"A simple non-enzymatic hydrogen peroxide sensor using gold nanoparticles-graphene-chitosan modified electrode","volume":"195","author":"Jia","year":"2014","journal-title":"Sens. Actuators Chem. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3390\/ma7042945","article-title":"Non-enzymatic Hydrogen Peroxide Sensors Based on Multi-wall Carbon Nanotube\/Pt Nanoparticle Nanohybrids","volume":"7","author":"Miao","year":"2014","journal-title":"Materials"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.3390\/s130303878","article-title":"Electrical Characterization and Hydrogen Peroxide Sensing Properties of Gold\/Nafion:Polypyrrole\/MWCNTs Electrochemical Devices","volume":"13","author":"Scandurra","year":"2013","journal-title":"Sensors"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8926","DOI":"10.3390\/s140508926","article-title":"Electrochemical Detection of p-Aminophenol by Flexible Devices Based on Multi-Wall Carbon Nanotubes Dispersed in Electrochemically Modified Nafion","volume":"14","author":"Scandurra","year":"2014","journal-title":"Sensors"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1039\/C6TB00336B","article-title":"Electrodeposition of chitosan based on coordination with metal ions in situ-generated by electrochemical oxidation","volume":"4","author":"Geng","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0032-3861(01)00685-1","article-title":"Contribution to the study of the complexation of copper by chitosan and oligomers","volume":"43","author":"Rhazi","year":"2002","journal-title":"Polymer"},{"key":"ref_35","first-page":"180","article-title":"Copper and Copper Oxides Nanoparticles Synthesized by Electrochemical Technique in Chitosan Solution","volume":"3","author":"Omar","year":"2016","journal-title":"Inter. J. Sci. Eng. Appli."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"63685","DOI":"10.1039\/C4RA12696C","article-title":"Chitosan coated copper-oxides nano particles: A novel electro-catalyst for CO2 reduction","volume":"4","author":"Basumallick","year":"2014","journal-title":"RSC Adv."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yang, G., Chen, F., and Yang, Z. (2012). Electrocatalytic Oxidation of Hydrogen Peroxide Based on the Shuttlelike Nano-CuO-Modified Electrode. Inter. J. Electrochem.","DOI":"10.1155\/2012\/194183"},{"key":"ref_38","first-page":"808","article-title":"Low Potential and Non-Enzymatic Hydrogen Peroxide Sensor Based on Copper Oxide Nanoparticle on Activated Pencil Graphite Electrode","volume":"28","author":"Kamyabi","year":"2016","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1752-153X-5-75","article-title":"Facile synthesis of flower like copper oxide and their application to hydrogen peroxide and nitrite sensing","volume":"5","author":"Zhang","year":"2011","journal-title":"Chem. Cent. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.colsurfa.2011.12.032","article-title":"Highly stable and redox active nano copper species stabilized functionalized-multiwalled carbon nanotube\/chitosan modified electrode for efficient hydrogen peroxide detection","volume":"395","author":"Annamalai","year":"2012","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jelechem.2011.09.015","article-title":"CuO nanoflowers as an electrochemical pH sensor and the effect of pH on the growth","volume":"662","author":"Zaman","year":"2011","journal-title":"J. Electroanal. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.snb.2017.06.076","article-title":"Simple electrochemical growth of copper nanoparticles decorated silver nanoleaves for the sensitive determination of hydrogen peroxide in clinical lens cleaning solutions","volume":"252","author":"Devasenathipathy","year":"2017","journal-title":"Sens. Actuators Chem. B"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00604-017-2105-7","article-title":"A glassy carbon electrode modified with FeS nanosheets as a highly sensitive amperometric sensor for hydrogen peroxide","volume":"184","author":"Jin","year":"2017","journal-title":"Microchem. Acta."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1039\/C6AY03421G","article-title":"Ni\u2013Al\/layered double hydroxide\/Ag nanoparticle composite modified carbon-paste electrode as a renewable electrode and novel electrochemical sensor for hydrogen peroxide","volume":"9","author":"Habibi","year":"2017","journal-title":"Anal. Methods"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1039\/C6AY02196D","article-title":"Ni doped Ag@C core\u2013shell nanomaterials and their application in electrochemical H2O2 sensing","volume":"9","author":"Sheng","year":"2017","journal-title":"Anal. Methods"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.20964\/2017.07.55","article-title":"Electrochemical Synthesis of a Binary Mn-Co Oxides Decorated Graphene Nanocomposites for Application in Nonenzymatic H2O2 Sensing","volume":"12","author":"Li","year":"2017","journal-title":"Int. J. Electrochem. Sci."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/10\/2198\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:45:47Z","timestamp":1760208347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/17\/10\/2198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,24]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10]]}},"alternative-id":["s17102198"],"URL":"https:\/\/doi.org\/10.3390\/s17102198","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,24]]}}}