{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:44:35Z","timestamp":1781783075879,"version":"3.54.5"},"reference-count":20,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A lab-on-a-chip (LOC)-based non-invasive optical sensor for measuring glucose in saliva was fabricated. Existing glucose sensors utilizing blood require acquisition of a blood sample by pricking the finger, which is painful and inconvenient. To overcome these limitations, we propose a non-invasive glucose sensor with LOC, micro-electro-mechanical system and optical measurement technology. The proposed sensor for measuring glucose in saliva involves pretreatment, mixing, and measurement on a single tiny chip. Saliva containing glucose and glucose oxidase for glucose oxidation are injected through Inlets 1 and 2, respectively. Next, H2O2 is produced by the reaction between glucose and glucose oxidase in the pretreatment part. The saliva and generated H2O2 are mixed with a colorizing agent injected through Inlet 3 during the mixing part and the absorbance of the colorized mixture is measured in the measurement part. The absorbance of light increases as a function of glucose concentration at a wavelength of 630 nm. To measure the absorbance of the colorized saliva, a light-emitting diode with a wavelength of 630 nm and a photodiode were used during the measurement part. As a result, the measured output current of the photodiode decreased as glucose concentration in the saliva increased.<\/jats:p>","DOI":"10.3390\/s17112607","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T11:12:36Z","timestamp":1510571556000},"page":"2607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["A Lab-on-a-Chip-Based Non-Invasive Optical Sensor for Measuring Glucose in Saliva"],"prefix":"10.3390","volume":"17","author":[{"given":"Dong","family":"Jung","sequence":"first","affiliation":[{"name":"Graduate School of Electronics Engineering, Kyungpook National University, Daegu 41566, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daewoong","family":"Jung","sequence":"additional","affiliation":[{"name":"Aircraft System Technology Group, Korea Institute of Industrial Technology (KITECH), Daegu 42994, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong","family":"Kong","sequence":"additional","affiliation":[{"name":"Graduate School of Electronics Engineering, Kyungpook National University, Daegu 41566, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"ref_1","unstructured":"(2017, November 11). 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