{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:52:36Z","timestamp":1767772356203,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America\u2019s main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T. cruzi load measurements in settings where CD is most prevalent are needed to enable enhanced intervention strategies. This work analyzes the potential contribution of biosensing technologies, reviewing examples that have been tested and contrasted with traditional methods, both serological and parasitological (i.e., molecular detection by PCR), and discusses some emerging biosensing technologies that have been applied for this public health issue. Even if biosensing technologies still require further research efforts to develop portable systems, we arrive at the conclusion that biosensors could improve the accuracy of CD diagnosis and the follow-up of patients\u2019 treatments in terms of the rapidity of results, small sample volume, high integration, ease of use, real-time and low cost detection when compared with current conventional technologies.<\/jats:p>","DOI":"10.3390\/s17112629","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T11:13:35Z","timestamp":1510744415000},"page":"2629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Biosensors to Diagnose Chagas Disease: A Brief Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Mar\u00eda-Isabel","family":"Rocha-Gaso","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Computacionales, Universidad de Quintana Roo, Unidad Canc\u00fan, 77519 Canc\u00fan, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-1408","authenticated-orcid":false,"given":"Luis-Jes\u00fas","family":"Villarreal-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias de la Ingenier\u00eda y Tecnolog\u00eda, Cuerpo Acad\u00e9mico de Bioingenier\u00eda y Salud Ambiental, Universidad Aut\u00f3noma de Baja California, 22260 Tijuana, Mexico"}]},{"given":"Denis","family":"Beyssen","sequence":"additional","affiliation":[{"name":"Institut Jean Lamour, 54600 Villers-l\u00e8s-Nancy, France"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Sarry","sequence":"additional","affiliation":[{"name":"Institut Jean Lamour, 54600 Villers-l\u00e8s-Nancy, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-2958","authenticated-orcid":false,"given":"Marco-Antonio","family":"Reyna","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias de la Ingenier\u00eda y Tecnolog\u00eda, Cuerpo Acad\u00e9mico de Bioingenier\u00eda y Salud Ambiental, Universidad Aut\u00f3noma de Baja California, 22260 Tijuana, Mexico"}]},{"given":"Carlos-Napole\u00f3n","family":"Ibarra-Cerde\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Ecolog\u00eda Humana, Cinvestav Unidad M\u00e9rida, 97310 M\u00e9rida, Mexico"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0074-02761909000200008","article-title":"Nova tripanozomiaze humana: Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem","volume":"1","author":"Chagas","year":"1909","journal-title":"Mem. 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