{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:07:18Z","timestamp":1774022838654,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this work, a biosensing method based on in situ, fast, and sensitive measurements of ellipsometric parameters (\u03a8, \u2206) is proposed. Bare silicon wafer substrate is functionalized and used to bind biomolecules in the solution. Coupled with a 45\u00b0 dual-drive symmetric photoelastic modulator-based ellipsometry, the parameters \u03a8 and \u2206 of biolayer arising due to biomolecular interactions are determined directly, and the refractive index (RI) of the solution and the effective thickness and surface mass density of the biolayer for various interaction time can be further monitored simultaneously. To illustrate the performance of the biosensing method, immunosensing for immunoglobulin G (IgG) was taken as a case study. The experiment results show that the biosensor response of the limit of detection for IgG is 15 ng\/mL, and the data collection time is in milliseconds. Moreover, the method demonstrates a good specificity. Such technique is a promising candidate in developing a novel sensor which can realize fast and sensitive, label-free, easy operation, and cost-effective biosensing.<\/jats:p>","DOI":"10.3390\/s18010015","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T05:50:19Z","timestamp":1513921819000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fast and Sensitive Ellipsometry-Based Biosensing"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-5738","authenticated-orcid":false,"given":"Kewu","family":"Li","sequence":"first","affiliation":[{"name":"School of Information and Communication Engineering, North University of China, Taiyuan 030051, China"},{"name":"Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Information and Communication Engineering, North University of China, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jing","sequence":"additional","affiliation":[{"name":"School of Information and Communication Engineering, North University of China, Taiyuan 030051, China"},{"name":"Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[{"name":"Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Information and Communication Engineering, North University of China, Taiyuan 030051, China"},{"name":"Engineering Technology Research Center of Shanxi Province for Opto-Electric Information and Instrument, Taiyuan 030051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrd838","article-title":"Optical biosensors in drug discovery","volume":"1","author":"Cooper","year":"2002","journal-title":"Nat. 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