{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:05:02Z","timestamp":1783181102764,"version":"3.54.6"},"reference-count":77,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T00:00:00Z","timestamp":1515283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Noble transition metals, like palladium (Pd) and platinum (Pt), have been well-known for their excellent catalytic and electrochemical properties. However, they have been considered non-active for surface enhanced Raman spectroscopy (SERS). In this work, we explore the scattering contributions of Pd and Pt for the detection of organic molecules. The Pd and Pt nanostructures were synthesized on silicon substrate using a modified galvanic displacement method. The results show Pt nanoparticles and dendritic Pd nanostructures with controlled density and size. The influence of surfactants, including sodium dodecyl sulfate and cetyltrimethylammonium bromide, on the size and morphology of the nanostructures was investigated. The Pd and Pt nanostructures with a combination of large size and high density were then used to explore their applicability for the detection of 10\u22125 M Rhodamine 6G and 10\u22122 M paraoxon.<\/jats:p>","DOI":"10.3390\/s18010147","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T12:26:02Z","timestamp":1515414362000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Exploring the Efficacy of Platinum and Palladium Nanostructures for Organic Molecule Detection via Raman Spectroscopy"],"prefix":"10.3390","volume":"18","author":[{"given":"Minh","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Whale","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Iowa State University, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-1898","authenticated-orcid":false,"given":"Sonal","family":"Padalkar","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Iowa State University, Ames, IA 50011, USA"},{"name":"Microelectronics Research Center, Iowa State University, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.surfrep.2007.08.002","article-title":"Metallization and nanostructuring of semiconductor surfaces by galvanic displacement processes","volume":"62","author":"Carraro","year":"2007","journal-title":"Surf. Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF03214674","article-title":"A Review of Electroless Gold Deposition","volume":"17","author":"Ali","year":"1984","journal-title":"Gold Bull."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1021\/jp013396p","article-title":"Gold deposition by galvanic displacement on semiconductor surfaces: Effect of substrate on adhesion","volume":"106","author":"Magagnin","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1021\/la902032x","article-title":"Galvanic Deposition of Pt Clusters on Silicon: Effect of HF Concentration and Application as Catalyst for Silicon Nanowire Growth","volume":"26","author":"Cerruti","year":"2010","journal-title":"Langmuir"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"C47","DOI":"10.1149\/1.1374036","article-title":"Selective copper metallization by electrochemical contact displacement with amorphous silicon film","volume":"4","author":"Lee","year":"2001","journal-title":"Electrochem. Solid State Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1021\/nn201109s","article-title":"Constructing Metal-Based Structures on Nanopatterned Etched Silicon","volume":"5","author":"Zhang","year":"2011","journal-title":"ACS Nano"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1021\/am302226q","article-title":"Electroless Patterned Assembly of Metal. Nanoparticles on Hydrogen-Terminated Silicon Surfaces for Applications in Photoelectrocatalysis","volume":"5","author":"Fabre","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1021\/nl025790k","article-title":"Electroless nanoparticle film deposition compatible with photolithography, microcontact printing, and dip-pen nanolithography patterning technologies","volume":"2","author":"Porter","year":"2002","journal-title":"Nano Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1039\/b400488b","article-title":"Efficient SERS substrates made by electroless silver deposition into patterned silicon structures","volume":"14","author":"Liu","year":"2004","journal-title":"J. Mater. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1039\/C1CE05912B","article-title":"One-step growth of needle and dendritic gold nanostructures on silicon for surface enhanced Raman scattering","volume":"14","author":"Lahiri","year":"2012","journal-title":"CrystEngComm"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10832","DOI":"10.1002\/chem.201001038","article-title":"Platinum Nanaflowers on Scratched Silicon by Galvanic Displacement for an Effective SALDI Substrate","volume":"16","author":"Kawasaki","year":"2010","journal-title":"Chem. Eur. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14324","DOI":"10.1039\/c3dt51686e","article-title":"Ultrasensitive and recyclable SERS substrate based on Au-decorated Si nanowire arrays","volume":"42","author":"Yang","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1021\/am507857x","article-title":"3D Silver Nanoparticles Decorated Zinc Oxide\/Silicon Heterostructured Nanomace Arrays as High-Performance Surface-Enhanced Raman Scattering Substrates","volume":"7","author":"Huang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1039\/c2ce25254f","article-title":"Preferential face deposition of gold nanoparticles on silicon nanowires by galvanic displacement","volume":"14","author":"Sayed","year":"2012","journal-title":"CrystEngComm"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/jp310816f","article-title":"Electron tomography of Au-Catalyzed Semiconductor Nanowires","volume":"117","author":"Wu","year":"2013","journal-title":"J. Phys. Chem. C Nanomater. Interfaces"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.electacta.2007.04.058","article-title":"Nucleation behavior in electroless displacement deposition of metals on silicon from hydrofluoric acid solutions","volume":"53","author":"Yae","year":"2007","journal-title":"Electrochim. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.electacta.2004.02.009","article-title":"Morphological selection of electroless metal deposits on silicon in aqueous fluoride solution","volume":"49","author":"Peng","year":"2004","journal-title":"Electrochim. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1021\/nn900685a","article-title":"Heteroepitaxial Growth of Gold Nanostructures on Silicon by Galvanic Displacement","volume":"3","author":"Sayed","year":"2009","journal-title":"ACS Nano"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0039-6028(01)01589-8","article-title":"A structure study of the electroless deposition of Au on Si, H","volume":"496","author":"Warren","year":"2002","journal-title":"Surf. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1021\/am200144k","article-title":"Ultrasmooth Gold Thin Films by Self-Limiting Galvanic Displacement on Silicon","volume":"3","author":"Gutes","year":"2011","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1021\/ja060366x","article-title":"Nanoscale patterning of two metals on silicon surfaces using an ABC triblock copolymer template","volume":"128","author":"Aizawa","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"L553","DOI":"10.1016\/S0039-6028(99)00513-0","article-title":"Atomic force microscopy of Au deposition from aqueous HF onto Si(111)","volume":"430","author":"Rossiter","year":"1999","journal-title":"Surf. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nature06381","article-title":"Enhanced thermoelectric performance of rough silicon nanowires","volume":"451","author":"Hochbaum","year":"2008","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1021\/jp030071v","article-title":"Electrochemical characterization of the open-circuit deposition of platinum on silicon from fluoride solutions","volume":"107","author":"Gorostiza","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1557\/S0883769400047308","article-title":"Electroless Cu for VLSI","volume":"18","author":"Cho","year":"1993","journal-title":"MRS Bull."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"D244","DOI":"10.1149\/1.2829907","article-title":"Dynamics of copper deposition onto silicon by galvanic displacement","volume":"155","author":"Darosa","year":"2008","journal-title":"J. Electrochem. Soc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1021\/la034087o","article-title":"Characterization of electrolessly deposited copper and nickel nanofilms on modified Si(100) surface","volume":"19","author":"Zhang","year":"2003","journal-title":"Langmuir"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1116\/1.1690257","article-title":"Photoexcited electrodeposition of Cu structures on p-Si(001)","volume":"22","author":"Scheck","year":"2004","journal-title":"J. Vac. Sci. Technol. A"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"C16","DOI":"10.1149\/1.1344534","article-title":"Effect of silicon surface termination on copper deposition in deionized water","volume":"148","author":"Lim","year":"2001","journal-title":"J. Electrochem. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"C421","DOI":"10.1149\/1.1370964","article-title":"Spectroscopic studies on electroless deposition of copper on a hydrogen-terminated Si(111) surface in fluoride solutions","volume":"148","author":"Ye","year":"2001","journal-title":"J. Electrochem. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/S0038-1101(99)00200-2","article-title":"Selective deposition of a thin copper film for metallization on silicon by the chemical bath process","volume":"43","author":"Dhingra","year":"1999","journal-title":"Solid State Electron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0022-0728(92)80406-T","article-title":"The influence of hydrofluoric-acid concentration on electroless copper deposition onto silicon","volume":"333","author":"Nagahara","year":"1992","journal-title":"J. Electroanal. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1021\/nn400482d","article-title":"Highly Sensitive Glucose Sensor Based on Pt Nanoparticle\/Polyaniline Hydrogel Heterostructures","volume":"7","author":"Zhai","year":"2013","journal-title":"ACS Nano"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1021\/nn100852h","article-title":"Platinum Nanoparticle Ensemble-on-Graphene Hybrid. Nanosheet: One-Pot, Rapid Synthesis, and Used as New Electrode Material for Electrochemical Sensing","volume":"4","author":"Guo","year":"2010","journal-title":"ACS Nano"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.snb.2010.03.084","article-title":"Palladium nanostructures from galvanic displacement as hydrogen peroxide sensor","volume":"147","author":"Gutes","year":"2010","journal-title":"Sens. Actuators B Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11728","DOI":"10.1021\/acs.langmuir.6b02122","article-title":"Tuning the Photoelectrocatalytic Hydrogen Evolution of Pt-Decorated Silicon Photocathodes by the Temperature and Time of Electroless Pt Deposition","volume":"32","author":"Fabre","year":"2016","journal-title":"Langmuir"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1021\/la7016165","article-title":"Effect of Pt particle size and distribution on photoelectrochemical hydrogen evolution by p-Si photocathodes","volume":"23","author":"Lombardi","year":"2007","journal-title":"Langmuir"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1016\/j.electacta.2010.07.075","article-title":"Surfactant-free and controllable synthesis of hierarchical platinum nanostructures and their comparative studies in electrocatalysis, surface-enhanced Raman scattering and surface wettability","volume":"55","author":"Ye","year":"2010","journal-title":"Electrochim. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15052","DOI":"10.1016\/j.ijhydene.2011.08.072","article-title":"Effect of deposition potential on the structure and electrocatalytic behavior of Pt micro\/nanoparticles","volume":"36","author":"Zhang","year":"2011","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"10445","DOI":"10.1039\/C4CE01226G","article-title":"Facile synthesis and electrocatalytic properties of dendritic palladium nanostructures","volume":"16","author":"Bai","year":"2014","journal-title":"CrystEngComm"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11169","DOI":"10.1039\/C4NR02896A","article-title":"Facile and rapid synthesis of Pd nanodendrites for electrocatalysis and surface-enhanced Raman scattering applications","volume":"6","author":"Kannan","year":"2014","journal-title":"Nanoscale"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.electacta.2013.07.079","article-title":"Role of catalyst concentration on metal assisted chemical etching of silicon","volume":"109","author":"Cichoszewski","year":"2013","journal-title":"Electrochim. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1021\/jp0257449","article-title":"Surface-enhanced Raman scattering: From noble to transition metals and from rough surfaces to ordered nanostructures","volume":"106","author":"Tian","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.anchem.1.031207.112814","article-title":"Surface-Enhanced Raman Spectroscopy","volume":"1","author":"Stiles","year":"2008","journal-title":"Annu. Rev. Anal. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1021\/ja071269m","article-title":"SERS at structured palladium and platinum surfaces","volume":"129","author":"Abdelsalam","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1039\/b616986d","article-title":"Expanding generality of surface-enhanced Raman spectroscopy with borrowing SERS activity strategy","volume":"34","author":"Tian","year":"2007","journal-title":"Chem. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0039-6028(97)01030-3","article-title":"Investigation of surface-enhanced Raman scattering from platinum electrodes using a confocal Raman microscope: Dependence of surface roughening pretreatment","volume":"406","author":"Cai","year":"1998","journal-title":"Surf. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1021\/jp066122g","article-title":"Electrochemically roughened palladium electrodes for surface-enhanced Raman spectroscopy: Methodology, mechanism, and application","volume":"111","author":"Liu","year":"2007","journal-title":"J. Phys. Chem. C"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/jp962049q","article-title":"Extending surface Raman spectroscopy to transition metal surfaces for practical applications. 1. Vibrational properties of thiocyanate and carbon monoxide adsorbed on electrochemically activated platinum surfaces","volume":"101","author":"Tian","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.1039\/c1ce05557g","article-title":"Palladium crystals of various morphologies for SERS enhancement","volume":"13","author":"Chen","year":"2011","journal-title":"CrystEngComm"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"24585","DOI":"10.1021\/jp0638787","article-title":"Electrochemical fabrication of two-dimensional palladium nanostructures as substrates for surface enhanced Raman scattering","volume":"110","author":"Li","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1039\/b609164d","article-title":"Electrochemical preparation of platinum nanothorn assemblies with high surface enhanced Raman scattering activity","volume":"39","author":"Tian","year":"2006","journal-title":"Chem. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"21976","DOI":"10.1021\/jp106623y","article-title":"Synthesis of Palladium Nanoparticles and Their Applications for Surface-Enhanced Raman Scattering and Electrocatalysis","volume":"114","author":"Chen","year":"2010","journal-title":"J. Phys. Chem. C"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1021\/cm803421v","article-title":"Formation of Palladium Nanostructures in a Seed-Mediated Synthesis through an Oriented-Attachment-Directed Aggregation","volume":"21","author":"Bisson","year":"2009","journal-title":"Chem. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1149\/1.1837506","article-title":"Atomic force microscopy study of the silicon doping influence on the first stages of platinum electroless deposition","volume":"144","author":"Gorostiza","year":"1997","journal-title":"J. Electrochem. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1149\/1.1838152","article-title":"Different behavior in the deposition of platinum from HF solutions on n- and p-type (100) Si substrates","volume":"144","author":"Gorostiza","year":"1997","journal-title":"J. Electrochem. Soc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0927-7757(01)00854-8","article-title":"Laser ablation method: Use of surfactants to form the dispersed Ag nanoparticles","volume":"197","author":"Chen","year":"2002","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1039\/b711490g","article-title":"Shape control in gold nanoparticle synthesis","volume":"37","author":"Grzelczak","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/smll.200600015","article-title":"Pt nanoparticles surfactant-directed assembled into colloidal spheres and used as substrates in forming Pt nanorods and nanowires","volume":"2","author":"Chen","year":"2006","journal-title":"Small"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1002\/chem.200802457","article-title":"Facile Synthesis of Catalytically Active Platinum Nanosponges, Nanonetworks, and Nanodendrites","volume":"15","author":"Lin","year":"2009","journal-title":"Chem. A Eur. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.arabjc.2014.11.030","article-title":"Shape-directing role of cetyltrimethylammonium bromide on the morphology of extracellular synthesis of silver nanoparticles","volume":"8","author":"Obaid","year":"2015","journal-title":"Arab. J. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cplett.2005.10.028","article-title":"Surface-enhanced Raman scattering of 4-mercaptopyridine on thin films of nanoscale Pd cubes, boxes, and cages","volume":"417","author":"McLellan","year":"2006","journal-title":"Chem. Phys. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"035605","DOI":"10.1088\/0957-4484\/21\/3\/035605","article-title":"The synthesis and characterization of platinum nanoparticles: A method of controlling the size and morphology","volume":"21","author":"Nguyen","year":"2010","journal-title":"Nanotechnology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"A1051","DOI":"10.1364\/OE.19.0A1051","article-title":"Broadband antireflection and absorption enhancement by forming nano-patterned Si structures for solar cells","volume":"19","author":"Liu","year":"2011","journal-title":"Opt. Express"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1021\/cr300020c","article-title":"Nanomaterials for Sensing and Destroying Pesticides","volume":"112","author":"Aragay","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.saa.2013.10.013","article-title":"Synthesis of silver nanocubes as a SERS substrate for the determination of pesticide paraoxon and thiram","volume":"121","author":"Wang","year":"2014","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"He, X., Gao, Y., Mahjouri-Samani, M., Black, P., Allen, J., Mitchell, M., Xiong, W., Zhou, Y., Jiang, L., and Lu, Y. (2012). Surface-enhanced Raman spectroscopy using gold-coated horizontally aligned carbon nanotubes. Nanotechnology, 23.","DOI":"10.1088\/0957-4484\/23\/20\/205702"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1021\/j150668a038","article-title":"Surface-enhanced resonance raman-spectroscopy of rhodamine-6G adsorbed on colloidal silver","volume":"88","author":"Hildebrandt","year":"1984","journal-title":"J. Phys. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.2147\/IJN.S24785","article-title":"Biosynthesis of gold nanoparticles using chloroplasts","volume":"6","author":"Zhang","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"14611","DOI":"10.1039\/c3cp52564c","article-title":"Direct conversion of silver complexes to nanoscale hexagonal columns on a copper alloy for plasmonic applications","volume":"15","author":"Yamamoto","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.talanta.2014.03.075","article-title":"Polystyrene\/Ag nanoparticles as dynamic surface-enhanced Raman spectroscopy substrates for sensitive detection of organophosphorus pesticides","volume":"127","author":"Li","year":"2014","journal-title":"Talanta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"13794","DOI":"10.1021\/jp0687908","article-title":"Surface enhanced Raman scattering enhancement factors: A comprehensive study","volume":"111","author":"Blackie","year":"2007","journal-title":"J. Phys. Chem. C"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1369-7021(12)70017-2","article-title":"SERS: Materials, applications, and the future","volume":"15","author":"Sharma","year":"2012","journal-title":"Mater. Today"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/jp011730b","article-title":"Single-molecule and single-nanoparticle SERS: Examining the roles of surface active sites and chemical enhancement","volume":"106","author":"Doering","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Kneipp, K., Moskovits, M., and Kneipp, H. (2006). Surface-Enhanced Raman Scattering: Physics and Applications. Topics in Applied Physics, Springer.","DOI":"10.1007\/11663898"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00216-009-2761-5","article-title":"Surface-enhanced Raman spectroscopy: Substrate-related issues","volume":"394","author":"Lin","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1557\/mrs.2014.2","article-title":"Nanogaps for SERS applications","volume":"39","author":"Tong","year":"2014","journal-title":"MRS Bull."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/1\/147\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:50:23Z","timestamp":1760194223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/1\/147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,7]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["s18010147"],"URL":"https:\/\/doi.org\/10.3390\/s18010147","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,7]]}}}