{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:34:27Z","timestamp":1783766067762,"version":"3.55.0"},"reference-count":100,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The rapid and increasing use of the nanomaterials (NMs), nanostructured materials (NSMs), metal nanoclusters (MNCs) or nanocomposites (NCs) in the development of electrochemiluminescence (ECL) nanobiosensors is a significant area of study for its massive potential in the practical application of nanobiosensor fabrication. Recently, NMs or NSMs (such as AuNPs, AgNPs, Fe3O4, CdS QDs, OMCs, graphene, CNTs and fullerenes) or MNCs (such as Au, Ag, and Pt) or NCs of both metallic and non-metallic origin are being employed for various purposes in the construction of biosensors. In this review, we have selected recently published articles (from 2014\u20132017) on the current development and prospects of label-free or direct ECL nanobiosensors that incorporate NCs, NMs, NSMs or MNCs.<\/jats:p>","DOI":"10.3390\/s18010166","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T14:00:08Z","timestamp":1515506408000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Trends and Advances in Electrochemiluminescence Nanobiosensors"],"prefix":"10.3390","volume":"18","author":[{"given":"Mohammad","family":"Rizwan","sequence":"first","affiliation":[{"name":"Biosensors and Biotechnology Laboratory, Chemical Science Programme, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Faizah","family":"Mohd-Naim","sequence":"additional","affiliation":[{"name":"Biosensors and Biotechnology Laboratory, Chemical Science Programme, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam"},{"name":"Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-8506","authenticated-orcid":false,"given":"Minhaz Uddin","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Biosensors and Biotechnology Laboratory, Chemical Science Programme, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.3390\/s90705423","article-title":"Translocation biosensors cellular system integrators to dissect CRM1-dependent nuclear export by chemicogenomics","volume":"9","author":"Fetz","year":"2009","journal-title":"Sensors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1039\/C6RA00333H","article-title":"Electrochemical immunosensors and their recent nanomaterial-based signal amplification strategies: A review","volume":"6","author":"Lim","year":"2016","journal-title":"RSC Adv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1962.tb13623.x","article-title":"Electrode systems for continuous monitoring cardiovascular surgery","volume":"102","author":"Clark","year":"1962","journal-title":"Ann. 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