{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:01:32Z","timestamp":1769745692505,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>We report on characterization of an optical fiber-based multi-parameter sensor concept combining localized surface plasmon resonance (LSPR) signal and interferometric sensing using a double-clad optical fiber. The sensor consists of a micro-Fabry-Perot in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanorods on the facet of a cleaved double-clad optical fiber. The swelling degree of the hydrogel is measured interferometrically using the single-mode inner core, while the LSPR signal is measured using the multi-mode inner cladding. The quality of the interferometric signal is comparable to previous work on hydrogel micro-Fabry-Perot sensors despite having gold nanorods immobilized in the hydrogel. We characterize the effect of hydrogel swelling and variation of bulk solution refractive index on the LSPR peak wavelength. The results show that pH-induced hydrogel swelling causes only weak redshifts of the longitudinal LSPR mode, while increased bulk refractive index using glycerol and sucrose causes large blueshifts. The redshifts are likely due to reduced plasmon coupling of the side-by-side configuration as the interparticle distance increases with increasing swelling. The blueshifts with increasing bulk refractive index are likely due to alteration of the surface electronic structure of the gold nanorods donated by the anionic polymer network and glycerol or sucrose solutions. The recombination of biotin-streptavidin on gold nanorods in hydrogel showed a 7.6 nm redshift of the longitudinal LSPR. The LSPR response of biotin-streptavidin recombination is due to the change in local refractive index (RI), which is possible to discriminate from the LSPR response due to changes in bulk RI. In spite of the large LSPR shifts due to bulk refractive index, we show, using biotin-functionalized gold nanorods binding to streptavidin, that LSPR signal from gold nanorods embedded in the anionic hydrogel can be used for label-free biosensing. These results demonstrate the utility of immobilizing gold nanorods in a hydrogel on a double-clad optical fiber-end facet to obtain multi-parameter sensing.<\/jats:p>","DOI":"10.3390\/s18010187","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T13:36:15Z","timestamp":1515677775000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["LSPR and Interferometric Sensor Modalities Combined Using a Double-Clad Optical Fiber"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-3414","authenticated-orcid":false,"given":"Harald","family":"Muri","sequence":"first","affiliation":[{"name":"Department of Electronic Systems, Norwegian University of Science and Technology, Gunnerus Gate 1, 7012 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andon","family":"Bano","sequence":"additional","affiliation":[{"name":"Department of Electronic Systems, Norwegian University of Science and Technology, Gunnerus Gate 1, 7012 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag","family":"Hjelme","sequence":"additional","affiliation":[{"name":"Department of Electronic Systems, Norwegian University of Science and Technology, Gunnerus Gate 1, 7012 Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.3390\/s120303018","article-title":"Size Matters: Problems and Advantages Associated with Highly Miniaturized Sensors","volume":"12","author":"Dahlin","year":"2012","journal-title":"Sensors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1111\/j.1742-4658.2007.06078.x","article-title":"Optical-fiber bundles","volume":"274","author":"Gorris","year":"2007","journal-title":"FEBS J."},{"key":"ref_3","unstructured":"Choudhary, T.R., Tanner, M.G., Megia-Fernandez, A., Harrington, K., Wood, H.A., Chankeshwara, S., Zhu, P., Choudhury, D., Yu, F., and Thomson, R.R. 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