{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:49:31Z","timestamp":1760550571702,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) represents the prevalent type of dementia in the elderly, and is characterized by the presence of neurofibrillary tangles and amyloid plaques that eventually leads to the loss of neurons, resulting in atrophy in specific brain areas. Although the process of degeneration can be visualized through various modalities of medical imaging and has proved to be a valuable biomarker, the accurate diagnosis of Alzheimer\u2019s disease remains a challenge, especially in its early stages. In this paper, we propose a novel classification method for Alzheimer\u2019s disease\/cognitive normal discrimination in structural magnetic resonance images (MRI), based on the extension of the concept of histons to volumetric images. The proposed method exploits the relationship between grey matter, white matter and cerebrospinal fluid degeneration by means of a segmentation using supervoxels. The calculated histons are then processed for a reduction in dimensionality using principal components analysis (PCA) and the resulting vector is used to train an support vector machine (SVM) classifier. Experimental results using the OASIS-1 database have proven to be a significant improvement compared to a baseline classification made using the pipeline provided by Clinica software.<\/jats:p>","DOI":"10.3390\/s18061752","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T03:04:27Z","timestamp":1527649467000},"page":"1752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Supervoxels-Based Histon as a New Alzheimer\u2019s Disease Imaging Biomarker"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-6328","authenticated-orcid":false,"given":"C\u00e9sar","family":"Toro","sequence":"first","affiliation":[{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Campus de Montegancedo, Universidad Polit\u00e9cnica de Madrid, 28233 Pozuelo de Alarc\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-9293","authenticated-orcid":false,"given":"Consuelo","family":"Gonzalo-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Campus de Montegancedo, Universidad Polit\u00e9cnica de Madrid, 28233 Pozuelo de Alarc\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-481X","authenticated-orcid":false,"given":"Angel","family":"Garc\u00eda-Pedrero","sequence":"additional","affiliation":[{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Campus de Montegancedo, Universidad Polit\u00e9cnica de Madrid, 28233 Pozuelo de Alarc\u00f3n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-6798","authenticated-orcid":false,"given":"Ernestina","family":"Menasalvas Ruiz","sequence":"additional","affiliation":[{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Campus de Montegancedo, Universidad Polit\u00e9cnica de Madrid, 28233 Pozuelo de Alarc\u00f3n, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: A Delphi consensus study","volume":"366","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0197-4580(97)00056-0","article-title":"Frequency of stages of Alzheimer-related lesions in different age categories","volume":"18","author":"Braak","year":"1997","journal-title":"Neurobiol. 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