{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:57:07Z","timestamp":1772071027917,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21405024"],"award-info":[{"award-number":["21405024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A highly sensitive nitrite (NO2\u2212) electrochemical sensor is fabricated using glassy carbon electrode modified with Au nanoparticle and grapheme oxide. Briefly, this electrochemical sensor was prepared by drop-coating graphene oxide-chitosan mixed film on the surface of the electrode and then electrodepositing a layer of Au nanoparticle using cyclic voltammetry. The electrochemical behavior of NO2\u2212 on the sensor was investigated by cyclic voltammetry and amperometric i-t curve. The results showed that the sensor exhibited better electrocatalytic activity for NO2\u2212 in 0.1 mol\/L phosphate buffer solution (PBS) (pH 5.0). The oxidation peak current was positively correlated with NO2\u2212 concentration in the ranges of 0.9 \u00b5M to 18.9 \u00b5M. The detection limit was estimated to be 0.3 \u00b5M. In addition, the interference of some common ions (e.g., NO3\u2212, CO32\u2212, SO42\u2212, Cl\u2212, Ca2+ and Mg2+) and oxidizable compound including sodium sulfite and ascorbic acid in the detection of nitrite was also studied. The results show that this sensor is more sensitive and selective to NO2\u2212. Therefore, this electrochemical sensor provided an effective tool for the detection of NO2\u2212.<\/jats:p>","DOI":"10.3390\/s18071986","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T02:46:21Z","timestamp":1529635581000},"page":"1986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Electrochemical Determination of Nitrite by Au Nanoparticle\/Graphene-Chitosan Modified Electrode"],"prefix":"10.3390","volume":"18","author":[{"given":"Rijian","family":"Mo","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430073, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiemin","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Su","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengzhi","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengli","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Coastal Ecology Engineering Technology Research Center of Zhanjiang City, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Biomedical Materials and Interfaces, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-165X","authenticated-orcid":false,"given":"Chengyong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China"},{"name":"Coastal Ecology Engineering Technology Research Center of Zhanjiang City, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s13738-016-0944-5","article-title":"A novel electrochemical sensor based on gold nanorods and Nafion-modified GCE for the electrocatalytic oxidation of nitrite","volume":"13","author":"Rao","year":"2016","journal-title":"J. Iran. Chem. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.talanta.2016.12.067","article-title":"Preparation of high-quality palladium nanocubes heavily deposited on nitrogen-doped graphene nanocomposites and their application for enhanced electrochemical sensing","volume":"165","author":"Shen","year":"2017","journal-title":"Talanta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.snb.2016.07.073","article-title":"A novel nitrite biosensor based on the direct electrochemistry of horseradish peroxidase immobilized on porous Co3O4 nanosheets and reduced graphene oxide composite modified electrode","volume":"238","author":"Liu","year":"2017","journal-title":"Sens. Actuators B-Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00604-015-1717-z","article-title":"Electrochemical sensor for nitrite using a glassy carbon electrode modified with gold-copper nanochain networks","volume":"183","author":"Huang","year":"2016","journal-title":"Microchim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jcis.2016.10.088","article-title":"Electrochemical synthesis of gold nanoparticles decorated flower-like graphene for high sensitivity detection of nitrite","volume":"488","author":"Zou","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1016\/j.bios.2011.04.059","article-title":"A novel nitrite biosensor based on single-layer graphene nanoplatelet-protein composite film","volume":"26","author":"Yue","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bios.2017.02.036","article-title":"Gold dendrites Co-deposited with M13 virus as a biosensor platform for nitrite ions","volume":"94","author":"Seo","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"68798","DOI":"10.1039\/C6RA10690K","article-title":"Novel electrochemical preparation of gold nanoparticles decorated on a reduced graphene oxide-fullerene composite for the highly sensitive electrochemical detection of nitrite","volume":"6","author":"Rajkumar","year":"2016","journal-title":"RSC Adv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/elan.201600221","article-title":"Selective and sensitive nitrite sensor based on glassy carbon electrode modified by silver nanochains","volume":"29","author":"Shaikh","year":"2017","journal-title":"Electroanalysis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1021\/ac202039h","article-title":"Peroxynitrous-acid-induced chemiluminescence of fluorescent carbon dots for nitrite sensing","volume":"83","author":"Lin","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.talanta.2014.09.046","article-title":"Nitrite sensing based on the carbon dots-enhanced chemiluminescence from peroxynitrous acid and carbonate","volume":"132","author":"Lin","year":"2015","journal-title":"Talanta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.talanta.2012.04.008","article-title":"A fast and sensitive method for the determination of nitrite in human plasma by capillary electrophoresis with fluorescence detection","volume":"97","author":"Wang","year":"2012","journal-title":"Talanta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1016\/j.chroma.2009.01.096","article-title":"Selective determination method for measurement of nitrite and nitrate in water samples using high-performance liquid chromatography with post-column photochemical reaction and chemiluminescence detection","volume":"1216","author":"Kodamatani","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.watres.2015.08.031","article-title":"Estimation of nitrite in source-separated nitrified urine with UV spectrophotometry","volume":"85","author":"Masic","year":"2015","journal-title":"Water Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.microc.2012.03.026","article-title":"Indirect cloud point extraction and spectrophotometric determination of nitrite in water and meat products","volume":"104","author":"Pourreza","year":"2012","journal-title":"Microchem. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1039\/C4AN01924E","article-title":"A facile fabrication of copper particle-decorated novel graphene flower composites for enhanced detecting of nitrite","volume":"140","author":"Wang","year":"2015","journal-title":"Analyst"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1039\/C7AY01004D","article-title":"A sensitive and selective electrochemical nitrite sensor based on a glassy carbon electrode modified with cobalt phthalocyanine-supported Pd nanoparticles","volume":"9","author":"Song","year":"2017","journal-title":"Anal. Methods"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0022-0728(01)00358-8","article-title":"New electrochemical sensors for detection of nitrites and nitrates","volume":"509","author":"Badea","year":"2001","journal-title":"J. Electroanal. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.bios.2009.09.024","article-title":"Graphene\/AuNPs\/chitosan nanocomposites film for glucose biosensing","volume":"25","author":"Shan","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/S1872-2040(13)60673-8","article-title":"Simultaneous electrochemical determination of sulphite and nitrite using a gold nanoparticle\/graphene-chitosan modified electrode","volume":"41","author":"Wang","year":"2013","journal-title":"Chin. J. Anal. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.snb.2014.01.043","article-title":"A simple non-enzymatic hydrogen peroxide sensor using gold nanoparticles-graphene-chitosan modified electrode","volume":"195","author":"Jia","year":"2014","journal-title":"Sens. Actuators B-Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"40111","DOI":"10.1039\/C5RA02661J","article-title":"Development of a novel nitrite electrochemical sensor by stepwise in situ formation of palladium and reduced graphene oxide nanocomposites","volume":"5","author":"Fu","year":"2015","journal-title":"RSC Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1039\/C5NJ02941D","article-title":"Au nanoparticle modified carbon paper electrode for an electrocatalytic oxidation nitrite sensor","volume":"40","author":"Wan","year":"2016","journal-title":"New J. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bios.2013.08.007","article-title":"Nitrite electrochemical biosensing based on coupled graphene and gold nanoparticles","volume":"51","author":"Jiang","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00604-013-0999-2","article-title":"A sensitive and selective nitrite sensor based on a glassy carbon electrode modified with gold nanoparticles and sulfonated graphene","volume":"180","author":"Li","year":"2013","journal-title":"Microchim. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1550103","DOI":"10.1142\/S0218625X15501036","article-title":"A graphene\/enzyme-based electrochemical sensor for sensitive detection of organophosphorus pesticides","volume":"23","author":"Zhou","year":"2016","journal-title":"Surf. Rev. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1039\/C6NJ03509D","article-title":"Novel low temperature (<37 \u00b0C) chitosan hydrogel fabrication under the synergistic effect of graphene oxide","volume":"41","author":"Dai","year":"2017","journal-title":"New J. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/c1an15486a","article-title":"A novel nitrite sensor based on graphene\/polypyrrole\/chitosan nanocomposite modified glassy carbon electrode","volume":"136","author":"Ye","year":"2011","journal-title":"Analyst"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.electacta.2010.10.058","article-title":"Layer-by-layer construction of multi-walled carbon nanotubes, zinc oxide, and gold nanoparticles integrated composite electrode for nitrite detection","volume":"56","author":"Lin","year":"2011","journal-title":"Electrochim. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.snb.2015.12.032","article-title":"An enzyme-free electrochemical sensor based on reduced graphene oxide\/Co3O4 nanospindle composite for sensitive detection of nitrite","volume":"227","author":"Haldorai","year":"2016","journal-title":"Sens. Actuators B-Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bios.2013.07.056","article-title":"Surface decoration of multi-walled carbon nanotubes modified carbon paste electrode with gold nanoparticles for electro-oxidation and sensitive determination of nitrite","volume":"51","author":"Afkhami","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jelechem.2009.04.023","article-title":"Au-Fe(III) nanoparticle modified glassy carbon electrode for electrochemical nitrite sensor","volume":"632","author":"Liu","year":"2009","journal-title":"J. Electroanal. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bios.2018.02.057","article-title":"A novel electrochemical sensor based on silver\/halloysite nanotube\/molybdenum disulfide nanocomposite for efficient nitrite sensing","volume":"109","author":"Taher","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.elecom.2012.02.009","article-title":"Highly selective amperometric nitrite sensor based on chemically reduced graphene oxide modified electrode","volume":"17","author":"Mani","year":"2012","journal-title":"Electrochem. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.electacta.2013.06.015","article-title":"Direct electrodeposion of reduced graphene oxide and dendritic copper nanoclusters on glassy carbon electrode for electrochemical detection of nitrite","volume":"107","author":"Zhang","year":"2013","journal-title":"Electrochim. Acta"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jelechem.2013.12.011","article-title":"Electrochemical sensor for sensitive determination of nitrite based on the PAMAM dendrimer-stabilized silver nanoparticles","volume":"717","author":"Ning","year":"2014","journal-title":"J. Electroanal. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jelechem.2011.11.006","article-title":"Synthesis of crystalline silver nanoplates and their application for detection of nitrite in foods","volume":"664","author":"Wang","year":"2012","journal-title":"J. Electroanal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.apsusc.2013.01.132","article-title":"A novel and simple electrochemical sensor for electrocatalytic reduction of nitrite and oxidation of phenylhydrazine based on poly (o-anisidine) film using ionic liquid carbon paste electrode","volume":"271","author":"Ojani","year":"2013","journal-title":"Appl. Surf. Sci."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/7\/1986\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:09:37Z","timestamp":1760195377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/7\/1986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"alternative-id":["s18071986"],"URL":"https:\/\/doi.org\/10.3390\/s18071986","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]}}}