{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:55:15Z","timestamp":1773104115001,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21405093"],"award-info":[{"award-number":["21405093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Both adenosine triphosphate (ATP) and glucose are important to human health, and their abnormal levels are closely related to angiocardiopathy and hypoglycaemia. Therefore, the simultaneous determination of ATP and glucose with a single test mode is highly desirable for disease diagnostics and early recognition. Herein, a new fluorescence on\/off switch sensing platform is developed by carbon nanodots (CNDs) to detect ATP and glucose simultaneously. The fluorescence of CNDs can be quenched by Cu2+ and hydrogen peroxide (H2O2), due to the formation of hydroxyl radicals (\u00b7OH) produced in the Cu-Fenton reaction. Based on the high affinity of Cu2+ with ATP, the fluorescence of CNDs will recover effectively after adding ATP. Additionally, glucose can be efficiently catalyzed by glucose oxidase (GOx) to generate H2O2, so the platform can also be utilized to analyze glucose. Under optimum conditions, this sensing platform displays excellent sensitivity and the linear ranges are from 0.1 to 7 \u03bcM for ATP with a limit of detection (LOD) of 30.2 nM, and from 0.1 to 7 mM for glucose with a LOD 39.8 \u03bcM, respectively. Benefiting from the high sensitivity and selectivity, this sensing platform is successfully applied for simultaneous detection of ATP and glucose in human serum samples with satisfactory recoveries.<\/jats:p>","DOI":"10.3390\/s18072151","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T12:23:02Z","timestamp":1530706982000},"page":"2151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-9813","authenticated-orcid":false,"given":"Fei","family":"Qu","sequence":"first","affiliation":[{"name":"The Key Laboratory of Life-Organic Analysis, Qufu Normal University, Qufu 273165, China"},{"name":"Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Qufu Normal University, Qufu 273165, China"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Life-Organic Analysis, Qufu Normal University, Qufu 273165, China"},{"name":"Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Qufu Normal University, Qufu 273165, China"}]},{"given":"Wenli","family":"Han","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Chongqing Medical University, Chongqing 400016, China"}]},{"given":"Lian","family":"Xia","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Life-Organic Analysis, Qufu Normal University, Qufu 273165, China"},{"name":"Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Qufu Normal University, Qufu 273165, China"}]},{"given":"Jinmao","family":"You","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Life-Organic Analysis, Qufu Normal University, Qufu 273165, China"},{"name":"Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Qufu Normal University, Qufu 273165, China"},{"name":"Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bios.2014.07.064","article-title":"An exonuclease I-based label-free fluorometric aptasensor for adenosine triphosphate (ATP) detection with a wide concentration range","volume":"63","author":"Wei","year":"2015","journal-title":"Biosens. 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