{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:18:47Z","timestamp":1772727527644,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T00:00:00Z","timestamp":1532131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["13035"],"award-info":[{"award-number":["13035"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A rigid surface\u2013volume registration scheme is presented in this study to register computed tomography (CT) and free-hand tracked ultrasound (US) images of the talocrural joint. Prior to registration, bone surfaces expected to be visible in US are extracted from the CT volume and bone contours in 2D US data are enhanced based on monogenic signal representation of 2D US images. A 3D monogenic signal data is reconstructed from the 2D data using the position of the US probe recorded with an optical tracking system. When registering the surface extracted from the CT scan to the monogenic signal feature volume, six transformation parameters are estimated so as to optimize the sum of monogenic signal features over the transformed surface. The robustness of the registration algorithm was tested on a dataset collected from 12 cadaveric ankles. The proposed method was used in a clinical case study to investigate the potential of US imaging for pre-operative planning of arthroscopic access to talar (osteo)chondral defects (OCDs). The results suggest that registrations with a registration error of 2 mm and less is achievable, and US has the potential to be used in assessment of an OCD\u2019 arthroscopic accessibility, given the fact that 51% of the talar surface could be visualized.<\/jats:p>","DOI":"10.3390\/s18072375","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T02:58:56Z","timestamp":1532401136000},"page":"2375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Three-Dimensional Registration of Freehand-Tracked Ultrasound to CT Images of the Talocrural Joint"],"prefix":"10.3390","volume":"18","author":[{"given":"Nazl\u0131","family":"T\u00fcmer","sequence":"first","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628 CD Delft, The Netherlands"}]},{"given":"Aimee C.","family":"Kok","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center Amsterdam, Academic Medical Centre (AMC), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}]},{"given":"Frans M.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Imaging Science and Technology, Quantitative Imaging Group, Delft University of Technology (TU Delft), Lorentzweg 1, 2628 CJ Delft, The Netherlands"},{"name":"Department of Radiology, Academic Medical Centre (AMC), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}]},{"given":"Geert J.","family":"Streekstra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Centre (AMC), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}]},{"given":"Christian","family":"Askeland","sequence":"additional","affiliation":[{"name":"SINTEF Medical Technology, 7465 Trondheim, Norway"}]},{"given":"Gabrielle J. M.","family":"Tuijthof","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Center Amsterdam, Academic Medical Centre (AMC), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"},{"name":"Zuyd University of Applied Sciences, Research Centre Smart Devices, Nieuw Eyckholt 300, 6419 DJ Heerlen, The Netherlands"}]},{"given":"Amir A.","family":"Zadpoor","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628 CD Delft, The Netherlands"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3113\/FAI.2007.0154","article-title":"Osteochondral Lesions of the Talus: Localization and Morphologic Data from 424 Patients Using a Novel Anatomical Grid Scheme","volume":"28","author":"Raikin","year":"2007","journal-title":"Foot Ankle Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s00167-015-3518-7","article-title":"Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Elbow","volume":"24","author":"Heijink","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3113\/FAI.2011.0948","article-title":"Incidence of Osteochondral Lesions of the Talus in the United States Military","volume":"32","author":"Orr","year":"2011","journal-title":"Foot Ankle Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00167-009-0942-6","article-title":"Treatment of Osteochondral Lesions of the Talus: A Systematic Review","volume":"18","author":"Zengerink","year":"2010","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1083-7515(02)00064-5","article-title":"Systematic Review of Treatment Strategies for Osteochondral Defects of the Talar Dome","volume":"8","author":"Verhagen","year":"2003","journal-title":"Foot Ankle Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1007\/s11999-010-1764-z","article-title":"Clinical Cartilage Restoration: Evolution and Overview","volume":"469","author":"Farr","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.ultrasmedbio.2014.03.022","article-title":"Feasibility of Ultrasound Imaging of Osteochondral Defects Inthe Ankle: A Clinical Pilot Study","volume":"40","author":"Kok","year":"2014","journal-title":"Ultrasound Med. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.ultrasmedbio.2013.02.011","article-title":"Sensitivity and Specificity of Ultrasound in Detecting (Osteo)chondral Defects: A Cadaveric Study","volume":"39","author":"Tuijthof","year":"2013","journal-title":"Ultrasound Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.joca.2008.06.005","article-title":"Ultrasound in the Study and Monitoring of Osteoarthritis","volume":"16","author":"Bong","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1546-0096-7-12","article-title":"Inter -and Intraobserver Variation of Ultrasonographic Cartilage Thickness Assessments in Small and Large Joints in Healthy Children","volume":"7","author":"Spannow","year":"2009","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"944","DOI":"10.5312\/wjo.v6.i11.944","article-title":"Diagnosing, Planning and Evaluating Osteochondral Ankle Defects with Imaging Modalities","volume":"6","author":"Gerards","year":"2015","journal-title":"World J. Orthop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1109\/TMI.2005.862736","article-title":"Self-Calibrating 3D-Ultrasound-Based Bone Registration for Minimally Invasive Orthopedic Surgery","volume":"25","author":"Barratt","year":"2006","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_13","first-page":"235","article-title":"Towards Real-Time 3D US to CT Bone Image Registration Using Phase and Curvature Feature Based GMM Matching","volume":"Volume 6891","author":"Brounstein","year":"2011","journal-title":"International Conference on Medical Image Computing and Computer-Assisted Intervention"},{"key":"ref_14","first-page":"82","article-title":"3D Ultrasound-CT Registration in Orthopaedic Trauma Using GMM Registration with Optimized Particle Simulation-Based Data Reduction","volume":"Volume 15","author":"Hacihaliloglu","year":"2012","journal-title":"International Conference on Medical Image Computing and Computer-Assisted Intervention"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.media.2011.07.006","article-title":"Multi-Modal Registration of Speckle-Tracked Freehand 3D Ultrasound to CT in the Lumbar Spine","volume":"16","author":"Lang","year":"2012","journal-title":"Med. Image Anal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1109\/TMI.2007.901984","article-title":"Point-Based Rigid-Body Registration Using an Unscented Kalman Filter","volume":"26","author":"Moghari","year":"2007","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_17","first-page":"1000","article-title":"Cadaver Validation of Intensity-Based Ultrasound to CT Registration","volume":"Volume 3750","author":"Penney","year":"2005","journal-title":"International Conference on Medical Image Computing and Computer-Assisted Intervention"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/10929080209146523","article-title":"Three-Dimensional Image Registration of Phantom Vertebrae for Image-Guided Surgery: A Preliminary Study","volume":"7","author":"Muratore","year":"2002","journal-title":"Comput. Aided Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.ultrasmedbio.2009.06.1089","article-title":"Toward Registration of 3D Ultrasound and CT Images of the Spine in Clinical Praxis: Design and Evaluation of a Data Acquisition Protocol","volume":"35","author":"Winter","year":"2009","journal-title":"Ultrasound Med. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11548-010-0536-2","article-title":"Towards Accurate, Robust and Practical Ultrasound-CT Registration of Vertebrae for Image-Guided Spine Surgery","volume":"6","author":"Yan","year":"2011","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0531-5131(03)00396-0","article-title":"Bone Registration with 3D CT and Ultrasound Data Sets","volume":"1256","author":"Brendel","year":"2003","journal-title":"Int. Congr. Ser."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s11548-015-1247-5","article-title":"A Multi-Vertebrae CT to US Registration of the Lumbar Spine in Clinical Data","volume":"10","author":"Nagpal","year":"2015","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_23","first-page":"76250R","article-title":"Group-Wise Feature-Based Registration of CT and Ultrasound Images of Spine","volume":"Volume 7625","author":"Rasoulian","year":"2010","journal-title":"Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10929080309146097","article-title":"Ultrasound Registration of the Bone Surface for Surgical Navigation","volume":"8","author":"Amin","year":"2003","journal-title":"Comput. Aided Surg."},{"key":"ref_25","first-page":"586","article-title":"Method for Registration of 3-D Shapes","volume":"Volume 1611","author":"Besl","year":"1992","journal-title":"Sensor Fusion IV: Control Paradigms and Data Structures"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1109\/TEVC.2007.907558","article-title":"Registration of CT and Intraoperative 3-D Ultrasound Images of the Spine Using Evolutionary and Gradient-Based Methods","volume":"12","author":"Winter","year":"2008","journal-title":"IEEE Trans. Evol. Comput."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.arthro.2011.11.030","article-title":"Computed Tomography of the Ankle in Full Plantar Flexion: A Reliable Method for Preoperative Planning of Arthroscopic Access to Osteochondral Defects of the Talus","volume":"28","author":"Tuijthof","year":"2012","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1109\/TMI.2014.2332571","article-title":"Local Phase Tensor Features for 3-D Ultrasound to Statistical Shape+pose Spine Model Registration","volume":"33","author":"Hacihaliloglu","year":"2014","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11548-015-1292-0","article-title":"CustusX: An Open-Source Research Platform for Image-Guided Therapy","volume":"11","author":"Askeland","year":"2016","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1088\/0031-9155\/60\/9\/3499","article-title":"Versatile Robotic Probe Calibration for Position Tracking in Ultrasound Imaging","volume":"60","author":"Hofstad","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.joca.2016.07.015","article-title":"De Weinans, H.; Tuijthof, G.J.M.; Zadpoor, A.A. Bone Shape Difference between Control and Osteochondral Defect Groups of the Ankle Joint","volume":"24","author":"Blankevoort","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s11548-016-1370-y","article-title":"Registration of a Statistical Model to Intraoperative Ultrasound for Scaphoid Screw Fixation","volume":"11","author":"Anas","year":"2016","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1109\/TITB.2010.2090889","article-title":"Phase Based Level Set Segmentation of Ultrasound Images","volume":"15","author":"Belaid","year":"2009","journal-title":"IEEE Trans. Inf. Technol. Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.ultrasmedbio.2009.04.015","article-title":"Bone Surface Localization in Ultrasound Using Image Phase-Based Features","volume":"35","author":"Hacihaliloglu","year":"2009","journal-title":"Ultrasound Med. Biol."},{"key":"ref_35","first-page":"1","article-title":"Multi-Scale Analysis of Local Phase and Local Orientation for Dynamic Facial Expression Recognition","volume":"1","author":"Shojaeilangari","year":"2014","journal-title":"J. Multimed. Theory Appl."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1109\/78.969520","article-title":"The Monogenic Signal","volume":"49","author":"Felsberg","year":"2001","journal-title":"IEEE Trans. Image Process."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s11548-015-1181-6","article-title":"Bone Enhancement in Ultrasound Using Local Spectrum Variations for Guiding Percutaneous Scaphoid Fracture Fixation Procedures","volume":"10","author":"Anas","year":"2015","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1162\/106365601750190398","article-title":"Completely Derandomized Self-Adaptation in Evolution Strategies","volume":"9","author":"Hansen","year":"2001","journal-title":"Evol. Comput."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1118\/1.1445412","article-title":"A Comparative Study of Surface- and Volume-Based Techniques for the Automatic Registration between CT and SPECT Brain Images","volume":"29","author":"Kagadis","year":"2002","journal-title":"Med. Phys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1109\/TPAMI.2005.108","article-title":"Precision Range Image Registration Using a Robust Surface Interpenetration Measure and Enhanced Genetic Algorithms","volume":"27","author":"Silva","year":"2005","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1177\/0363546512455403","article-title":"Arthroscopic Accessibility of the Talus Quantified by Computed Tomography Simulation","volume":"40","author":"Tuijthof","year":"2012","journal-title":"Am. J. Sports Med."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/7\/2375\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:13:33Z","timestamp":1760195613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/7\/2375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,21]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"alternative-id":["s18072375"],"URL":"https:\/\/doi.org\/10.3390\/s18072375","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,21]]}}}