{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:02:51Z","timestamp":1768082571210,"version":"3.49.0"},"reference-count":75,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, we describe and test a new portable device that is able to deliver tactile interoceptive stimulation. The device works by delivering precise interoceptive parasympathetic stimuli to C-tactile afferents connected to the lamina I spinothalamocortical system. In humans, interoceptive stimulation can be used to enhance heart rate variability (HRV). To test the effectiveness of the device in enhancing HRV, 13 subjects were randomly assigned in a single-blind between-subjects design either to the experimental condition or to the control condition. In the experimental condition, subjects received stimulation with the developed device; in the control condition subjects received stimulation with static non-interoceptive pressure. Subjects\u2019 electrocardiograms (ECG) were recorded, with sampling at 1000 Hz for 5 min as a baseline, and then during the stimulations (11 min). Time domain analyses were performed to estimate the short-term vagally mediated component (rMSSD) of HRV. Results indicated that the experimental group showed enhanced rMSSD, compared to the control group. Moreover, frequency domain analyses indicated that high frequency band power, which reflects parasympathetic activity in humans, also appeared to be enhanced in the experimental group compared to control subjects. Conclusions and future challenges for an embodied perspective of rehabilitative medicine are discussed.<\/jats:p>","DOI":"10.3390\/s18082469","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T11:55:08Z","timestamp":1532951708000},"page":"2469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Toward an Embodied Medicine: A Portable Device with Programmable Interoceptive Stimulation for Heart Rate Variability Enhancement"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6850-6866","authenticated-orcid":false,"given":"Daniele","family":"Di Lernia","sequence":"first","affiliation":[{"name":"Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, Largo Gemelli, 1, 20100 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-7678","authenticated-orcid":false,"given":"Pietro","family":"Cipresso","sequence":"additional","affiliation":[{"name":"Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, Largo Gemelli, 1, 20100 Milan, Italy"},{"name":"Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Via Magnasco, 2, 20149 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Pedroli","sequence":"additional","affiliation":[{"name":"Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Via Magnasco, 2, 20149 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-106X","authenticated-orcid":false,"given":"Giuseppe","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Psychology, Universit\u00e0 Cattolica del Sacro Cuore, Largo Gemelli, 1, 20100 Milan, Italy"},{"name":"Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Via Magnasco, 2, 20149 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fnhum.2017.00120","article-title":"Embodied Medicine: Mens Sana in Corpore Virtuale Sano","volume":"11","author":"Riva","year":"2017","journal-title":"Front. Hum. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cortex.2017.07.013","article-title":"The neuroscience of body memory: From the self through the space to the others","volume":"104","author":"Riva","year":"2017","journal-title":"Cortex"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0959-4388(03)00090-4","article-title":"Interoception: The sense of the physiological condition of the body","volume":"13","author":"Craig","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0166-2236(92)90182-8","article-title":"Visceral nociceptors: A new world order?","volume":"15","author":"Cervero","year":"1992","journal-title":"Trends Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1113\/jphysiol.1985.sp015718","article-title":"Different types of slowly conducting afferent units in cat skeletal muscle and tendon","volume":"363","author":"Mense","year":"1985","journal-title":"J. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1152\/jn.00609.2001","article-title":"Activation of spinobulbar lamina I neurons by static muscle contraction","volume":"87","author":"Wilson","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? Interoception: The sense of the physiological condition of the body","volume":"3","author":"Craig","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1113\/jphysiol.1960.sp006491","article-title":"Cutaneous mechanoreceptors with afferent C fibres","volume":"152","author":"Iggo","year":"1960","journal-title":"J. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/hbm.21480","article-title":"Brain mechanisms for processing affective touch","volume":"34","author":"Gordon","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1098\/rstb.2009.0008","article-title":"Emotional moments across time: A possible neural basis for time perception in the anterior insula","volume":"364","author":"Craig","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neubiorev.2016.09.015","article-title":"Pain in the body. Altered interoception in chronic pain conditions: A systematic review","volume":"71","author":"Serino","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1038\/srep10818","article-title":"Altered resting state functional connectivity of anterior cingulate cortex in drug naive adolescents at the earliest stages of anorexia nervosa","volume":"5","author":"Gaudio","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pscychresns.2017.06.011","article-title":"White matter abnormalities in treatment-naive adolescents at the earliest stages of Anorexia Nervosa: A diffusion tensor imaging study","volume":"266","author":"Gaudio","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/npp.2015.174","article-title":"Altered Insula Activity during Visceral Interoception in Weight-Restored Patients with Anorexia Nervosa","volume":"41","author":"Kerr","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biopsych.2014.09.024","article-title":"Hunger does not motivate reward in women remitted from anorexia nervosa","volume":"77","author":"Wierenga","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.brat.2010.07.006","article-title":"Can you feel the beat? Interoceptive awareness is an interactive function of anxiety- and depression-specific symptom dimensions","volume":"48","author":"Dunn","year":"2010","journal-title":"Behav. Res. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/da.20504","article-title":"Differential effects of anxiety and depression on interoceptive accuracy","volume":"26","author":"Pollatos","year":"2009","journal-title":"Depression Anxiety"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnhum.2012.00323","article-title":"Major depressive disorder and alterations in insular cortical activity: A review of current functional magnetic imaging research","volume":"6","author":"Sliz","year":"2012","journal-title":"Front. Hum. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2011.04.004","article-title":"The insular cortex and the neuroanatomy of major depression","volume":"133","author":"Sprengelmeyer","year":"2011","journal-title":"J. Affect. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3389\/fnhum.2016.00550","article-title":"Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression","volume":"10","author":"Stephan","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stratmann, M., Konrad, C., Kugel, H., Krug, A., Schoning, S., Ohrmann, P., Uhlmann, C., Postert, C., Suslow, T., and Heindel, W. (2014). Insular and hippocampal gray matter volume reductions in patients with major depressive disorder. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102692"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnbeh.2015.00082","article-title":"Interoception in insula subregions as a possible state marker for depression-an exploratory fMRI study investigating healthy, depressed and remitted participants","volume":"9","author":"Wiebking","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tins.2008.09.009","article-title":"The hidden island of addiction: The insula","volume":"32","author":"Naqvi","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.neubiorev.2012.05.007","article-title":"The role of interoception in addiction: A critical review","volume":"36","author":"Clark","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1586\/ern.10.198","article-title":"Functional neuroimaging studies of post-traumatic stress disorder","volume":"11","author":"Hughes","year":"2011","journal-title":"Expert Rev. Neurother."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopsycho.2013.12.016","article-title":"Increased insula coactivation with salience networks in insomnia","volume":"97","author":"Chen","year":"2014","journal-title":"Biol. Psychol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biopsych.2014.11.005","article-title":"\u201cI Do Not Exist\u201d\u2014Cotard Syndrome in Insular Cortex Atrophy","volume":"77","author":"Chatterjee","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2045-5380-4-9","article-title":"Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression","volume":"4","author":"Gorka","year":"2014","journal-title":"Biol. Mood Anxiety Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nn.3969","article-title":"The dorsal posterior insula subserves a fundamental role in human pain","volume":"18","author":"Segerdahl","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1523\/JNEUROSCI.5173-08.2009","article-title":"Roles of the insular cortex in the modulation of pain: Insights from brain lesions","volume":"29","author":"Starr","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Olausson, H., Wessberg, J., and McGlone, F. (2016). Affective Touch and the Neurophysiology of CT Afferents, Springer.","DOI":"10.1007\/978-1-4939-6418-5"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nn896","article-title":"Unmyelinated tactile afferents signal touch and project to insular cortex","volume":"5","author":"Olausson","year":"2002","journal-title":"Nat. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.psychres.2016.01.078","article-title":"The perception of affective touch in anorexia nervosa","volume":"239","author":"Crucianelli","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Habig, K., Schanzer, A., Schirner, W., Lautenschlager, G., Dassinger, B., Olausson, H., Birklein, F., Gizewski, E.R., and Kramer, H.H. (2017). Low threshold unmyelinated mechanoafferents can modulate pain. BMC Neurol., 17.","DOI":"10.1186\/s12883-017-0963-6"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20160009","DOI":"10.1098\/rstb.2016.0009","article-title":"Affective touch and attachment style modulate pain: A laser-evoked potentials study","volume":"371","author":"Drabek","year":"2016","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnbeh.2014.00037","article-title":"Tactile C fibers and their contributions to pleasant sensations and to tactile allodynia","volume":"8","author":"Liljencrantz","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.celrep.2013.09.013","article-title":"TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice","volume":"5","author":"Delfini","year":"2013","journal-title":"Cell Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nature11810","article-title":"Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo","volume":"493","author":"Vrontou","year":"2013","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1523\/JNEUROSCI.23-25-08752.2003","article-title":"A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input","volume":"23","author":"Lu","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1523\/JNEUROSCI.2847-13.2014","article-title":"Human C-tactile afferents are tuned to the temperature of a skin-stroking caress","volume":"34","author":"Ackerley","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fpsyg.2013.00703","article-title":"Bodily pleasure matters: Velocity of touch modulates body ownership during the rubber hand illusion","volume":"4","author":"Crucianelli","year":"2013","journal-title":"Front. Psychol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1080\/02699931.2014.954529","article-title":"The effect of pain and the anticipation of pain on temporal perception: A role for attention and arousal","volume":"29","author":"Ogden","year":"2015","journal-title":"Cogn. Emot."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.concog.2015.07.006","article-title":"Stroke me for longer this touch feels too short: The effect of pleasant touch on temporal perception","volume":"36","author":"Ogden","year":"2015","journal-title":"Conscious. Cogn."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnhum.2018.00074","article-title":"Feel the Time. Time Perception as a Function of Interoceptive Processing","volume":"12","author":"Serino","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biopsycho.2017.07.007","article-title":"Heart rate variability is enhanced by long-lasting pleasant touch at CT-optimized velocity","volume":"128","author":"Triscoli","year":"2017","journal-title":"Biol. Psychol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/01.CIR.85.1.164","article-title":"Frequency domain measures of heart period variability and mortality after myocardial infarction","volume":"85","author":"Bigger","year":"1992","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jad.2018.04.071","article-title":"Heart rate variability alterations in late life depression: A meta-analysis","volume":"235","author":"Brown","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","article-title":"An Overview of Heart Rate Variability Metrics and Norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front. Public Health"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1152\/jn.1999.81.6.2753","article-title":"Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin","volume":"81","author":"Vallbo","year":"1999","journal-title":"J. Neurophysiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fnbeh.2014.00054","article-title":"Touch perceptions across skin sites: Differences between sensitivity, direction discrimination and pleasantness","volume":"8","author":"Ackerley","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2014.05.001","article-title":"Discriminative and affective touch: Sensing and feeling","volume":"82","author":"McGlone","year":"2014","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1152\/jn.00256.2002","article-title":"Receptive field properties of unmyelinated tactile afferents in the human skin","volume":"89","author":"Wessberg","year":"2003","journal-title":"J. Neurophysiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/jphysiol.1995.sp020622","article-title":"Receptive field characteristics of tactile units with myelinated afferents in hairy skin of human subjects","volume":"483","author":"Vallbo","year":"1995","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Macefield, V.G. (2009). Tactile C Fibers. Encyclopedia of Neuroscience, Springer.","DOI":"10.1007\/978-3-540-29678-2_5865"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1113\/jphysiol.1990.sp018135","article-title":"Low-threshold mechanoreceptive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve","volume":"426","author":"Nordin","year":"1990","journal-title":"J. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1540-8167.1996.tb00567.x","article-title":"Effect of graded increases in parasympathetic tone on heart rate variability","volume":"7","author":"Goldberger","year":"1996","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4161\/chan.22213","article-title":"Touch sense: Functional organization and molecular determinants of mechanosensitive receptors","volume":"6","author":"Roudaut","year":"2012","journal-title":"Channels"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3389\/fpsyg.2014.01040","article-title":"A healthy heart is not a metronome: An integrative review of the heart\u2019s anatomy and heart rate variability","volume":"5","author":"Shaffer","year":"2014","journal-title":"Front. Psychol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Standards of Measurement, Physiological Interpretation, and Clinical Use","volume":"93","author":"Variability","year":"1996","journal-title":"Circulation"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/sim.7263","article-title":"Analysis of small sample size studies using nonparametric bootstrap test with pooled resampling method","volume":"36","author":"Dwivedi","year":"2017","journal-title":"Stat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1540-8159.2010.02841.x","article-title":"A quantitative systematic review of normal values for short-term heart rate variability in healthy adults","volume":"33","author":"Nunan","year":"2010","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/2041-210X.12102","article-title":"Improving the reporting of p-values generated by randomization methods","volume":"4","author":"Ruxton","year":"2013","journal-title":"Methods Ecol. Evol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0008-6363(96)00081-8","article-title":"Physical activity influences heart rate variability and very-low-frequency components in Holter electrocardiograms","volume":"32","author":"Bernardi","year":"1996","journal-title":"Cardiovasc. Res."},{"key":"ref_64","first-page":"3660","article-title":"Dissociable effects of surprise and model update in parietal and anterior cingulate cortex","volume":"110","author":"Schuffelgen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/da.22155","article-title":"Insula and anterior cingulate GABA levels in posttraumatic stress disorder: Preliminary findings using magnetic resonance spectroscopy","volume":"31","author":"Rosso","year":"2014","journal-title":"Depression Anxiety"},{"key":"ref_66","first-page":"314","article-title":"Ghosts in the Machine. Interoceptive Modeling for Chronic Pain Treatment","volume":"10","author":"Serino","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_67","first-page":"308","article-title":"Positive and Transformative Technologies for Active Ageing","volume":"220","author":"Riva","year":"2016","journal-title":"Stud. Health Technol. Inf."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fneur.2018.00310","article-title":"What is the role of the placebo effect for pain relief in neurorehabilitation? Clinical implications from the Italian Consensus Conference on Pain in Neurorehabilitation","volume":"9","author":"Castelnuovo","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fneur.2018.00345","article-title":"Virtual Reality for Traumatic Brain Injury","volume":"9","author":"Zanier","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1089\/cyber.2017.0674","article-title":"The Role of Age on Multisensory Bodily Experience: An Experimental Study with a Virtual Reality Full-Body Illusion","volume":"21","author":"Serino","year":"2018","journal-title":"Cyberpsychol. Behav. Soc. Netw."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1469-8986.1993.tb02072.x","article-title":"Respiratory sinus arrhythmia, cardiac vagal tone, and respiration: Within- and between-individual relations","volume":"30","author":"Grossman","year":"1993","journal-title":"Psychophysiology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1469-8986.1991.tb00412.x","article-title":"Prediction of tonic parasympathetic cardiac control using respiratory sinus arrhythmia: The need for respiratory control","volume":"28","author":"Grossman","year":"1991","journal-title":"Psychophysiology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsycho.2005.11.014","article-title":"Toward understanding respiratory sinus arrhythmia: Relations to cardiac vagal tone, evolution and biobehavioral functions","volume":"74","author":"Grossman","year":"2007","journal-title":"Biol. Psychol."},{"key":"ref_74","first-page":"356","article-title":"Heart Rate and Respiratory Rate Influence on Heart Rate Variability Repeatability: Effects of the Correction for the Prevailing Heart Rate","volume":"7","author":"Sacha","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"37212","DOI":"10.1038\/srep37212","article-title":"Resting-state high-frequency heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls","volume":"6","author":"Quintana","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/8\/2469\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:15:21Z","timestamp":1760195721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/18\/8\/2469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":75,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["s18082469"],"URL":"https:\/\/doi.org\/10.3390\/s18082469","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}