{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:32:38Z","timestamp":1782523958882,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Simple and effective methods for the detection of the level of blood glucose are closely linked to the monitoring of people\u2019s health. In the study, MnO2 nanosheets with absorption range of 300 nm~500 nm and obvious yellow color were easily prepared and applied to detect glucose through their absorbance and color. The proposed method is based on the fact that a specific concentration of glucose can be quantitatively transformed into hydrogen peroxide (H2O2) under the catalytic effect of glucose oxidase. Based on the redox reaction of MnO2 with H2O2, yellow MnO2 can be converted into colorless Mn2+ to monitor the concentration of glucose. Under optimal conditions, a simple and effective visual assay for the sensitive and reliable detection of glucose was developed. The linear range was estimated to the range from 0 \u03bcM to 100 \u03bcM, with a detection limit of 12.8 \u03bcM. Furthermore, the proposed colorimetric assay based on MnO2 nanosheets can effectively detect blood glucose of clinical serum samples with accuracy and convenience.<\/jats:p>","DOI":"10.3390\/s18082525","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T03:03:15Z","timestamp":1533265395000},"page":"2525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A Simple and Effective Colorimetric Assay for Glucose Based on MnO2 Nanosheets"],"prefix":"10.3390","volume":"18","author":[{"given":"Zhengjun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohuang","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, the Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/acsnano.7b00905","article-title":"Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme-Mimicking Activities for Measuring Glucose and Lactate in Living Tissues","volume":"11","author":"Hu","year":"2017","journal-title":"ACS Nano"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.talanta.2015.06.059","article-title":"Iodophenol blue-enhanced luminol chemiluminescence and its application to hydrogen peroxide and glucose detection","volume":"146","author":"Yu","year":"2016","journal-title":"Talanta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/1521-4109(200005)12:9<666::AID-ELAN666>3.0.CO;2-C","article-title":"Electroanalysis of Glucose in Transcutaneously Extracted Samples","volume":"12","author":"Tierney","year":"2015","journal-title":"Electroanalysis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bios.2014.07.087","article-title":"A novel signal-off electrochemiluminescence biosensor for the determination of glucose based on double nanoparticles","volume":"63","author":"Liu","year":"2015","journal-title":"Biosens. 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