{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:18:30Z","timestamp":1762431510664,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A novel \u201cturn-on\u201d fluorescent copper biosensor is developed successfully based on the graphene oxide (GO)-dsDNA-CdTe quantum dots (QDs) complex via chemical crosslink method. The optical and structure properties of GO-dsDNA-CdTe QDs complex are studied by fluorescence (FL) spectra and transmission electron microscopy (TEM) in detail. It is demonstrated that the fluorescence quenching of CdTe QDs is a process of fluorescence resonance energy transfer (FRET) due to the essential surface and quenching properties of two-dimensional GO. Copper ions induce the catalytic reaction of DNA chain and irreversibly break at the cleavage site, which will cause the G-quadruplex formation, moreover further result in the CdTe QDs separated from GO and restored its fluorescence. Therefore, a significant recovery effect on the fluorescence of the GO-dsDNA-CdTe QDs complex is observed in the presence of copper ions. The fluorescence responses are concentration-dependent and can be well described by a linear equation. Compared with other metal ions, the sensor performs good selectivity for copper ions.<\/jats:p>","DOI":"10.3390\/s18082605","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T10:36:31Z","timestamp":1533810991000},"page":"2605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A \u201cTurn-On\u201d Fluorescence Copper Biosensor Based on DNA Cleavage-Dependent Graphene Oxide-dsDNA-CdTe Quantum Dots Complex"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-6145","authenticated-orcid":false,"given":"Liyun","family":"Ding","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Fiber Optic Sensing Technology, Wuhan University of Technology, Wuhan 430070, China"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Fiber Optic Sensing Technology, Wuhan University of Technology, Wuhan 430070, China"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Fiber Optic Sensing Technology, Wuhan University of Technology, Wuhan 430070, China"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Fiber Optic Sensing Technology, Wuhan University of Technology, Wuhan 430070, China"}]},{"given":"Wei","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Hubei University of Chinese Medicine, Wuhan 430065, China"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1039\/b822613j","article-title":"Colorimetric sensing of Cu(ii) by 2-methyl-3-[(pyridin-2-ylmethyl)-amino]-1,4-naphthoquinone: Cu(ii) induced deprotonation of NH responsible for color changes","volume":"1164","author":"Wu","year":"2009","journal-title":"Dalton Trans."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ana.20047","article-title":"Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo","volume":"55","author":"Sheline","year":"2004","journal-title":"Ann. 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