{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:47:03Z","timestamp":1783504023692,"version":"3.55.0"},"reference-count":72,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1C1B1016088"],"award-info":[{"award-number":["2016R1C1B1016088"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20132014M3A7B4051907"],"award-info":[{"award-number":["NRF\u20132014M3A7B4051907"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002460","name":"Chung-Ang University","doi-asserted-by":"publisher","award":["Chung-Ang University Graduate Research Scholarship in 2016"],"award-info":[{"award-number":["Chung-Ang University Graduate Research Scholarship in 2016"]}],"id":[{"id":"10.13039\/501100002460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Breakthroughs in the biomedical and regenerative therapy fields have led to the influential ability of stem cells to differentiate into specific types of cells that enable the replacement of injured tissues\/organs in the human body. Non-destructive identification of stem cell differentiation is highly necessary to avoid losses of differentiated cells, because most of the techniques generally used as confirmation tools for the successful differentiation of stem cells can result in valuable cells becoming irrecoverable. Regarding this issue, recent studies reported that both Raman spectroscopy and electrochemical sensing possess excellent characteristics for monitoring the behavior of stem cells, including differentiation. In this review, we focus on numerous studies that have investigated the detection of stem cell pluripotency and differentiation in non-invasive and non-destructive manner, mainly by using the Raman and electrochemical methods. Through this review, we present information that could provide scientific or technical motivation to employ or further develop these two techniques for stem cell research and its application.<\/jats:p>","DOI":"10.3390\/s18092755","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T11:12:42Z","timestamp":1534849962000},"page":"2755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3268-6732","authenticated-orcid":false,"given":"Intan Rosalina","family":"Suhito","sequence":"first","affiliation":[{"name":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novi","family":"Angeline","sequence":"additional","affiliation":[{"name":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Sik","family":"Choo","sequence":"additional","affiliation":[{"name":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Young","family":"Woo","sequence":"additional","affiliation":[{"name":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taejong","family":"Paik","sequence":"additional","affiliation":[{"name":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taek","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-Gu, Seoul 0189, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea"},{"name":"Integrative Research Center for Two-Dimensional Functional Materials, Institute of Interdisciplinary Convergence Research, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"741416","DOI":"10.1155\/2012\/741416","article-title":"Development of New Technologies for Stem Cell Research","volume":"2012","author":"Ma","year":"2012","journal-title":"J. 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