{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:51:25Z","timestamp":1778665885639,"version":"3.51.4"},"reference-count":55,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T00:00:00Z","timestamp":1538179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61572302"],"award-info":[{"award-number":["61572302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In this paper, a multifunctional biosensing platform for sensitively detecting Hg2+ and Ag+, based on ion-mediated base mismatch, fluorescent labeling, and strand displacement, is introduced. The sensor can also be used as an OR logic gate, the multifunctional design of sensors is realized. Firstly, orthogonal experiments with three factors and three levels were carried out on the designed sensor, and preliminary optimization of conditions was performed for subsequent experiments. Next, the designed sensor was tested the specificity and target selectivity under the optimized conditions, and the application to actual environmental samples further verified the feasibility. Generally, this is a convenient, fast, stable, and low-cost method that provides a variety of ideas and an experimental basis for subsequent research.<\/jats:p>","DOI":"10.3390\/s18103280","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T08:23:50Z","timestamp":1538468630000},"page":"3280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Multifunctional Molecular Probe for Detecting Hg2+ and Ag+ Based on Ion-Mediated Base Mismatch"],"prefix":"10.3390","volume":"18","author":[{"given":"Luhui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Life Science, Shaanxi Normal University, Xi\u2019an 710119, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Shaanxi Normal University, Xi\u2019an 710119, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Life Science, Shaanxi Normal University, Xi\u2019an 710119, China"},{"name":"Department of Computer Science, Shaanxi Normal University, Xi\u2019an 710119, China"},{"name":"National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, Xi\u2019an 710119, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,29]]},"reference":[{"key":"ref_1","first-page":"42","article-title":"The era of bio-computers is coming","volume":"29","author":"Xu","year":"2014","journal-title":"Chin. 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