{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:07:53Z","timestamp":1760425673019,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:00:00Z","timestamp":1541203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61875102","61675113","61527808"],"award-info":[{"award-number":["61875102","61675113","61527808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Research Program of Shenzhen City","award":["JCYJ20160428182247170","JCYJ20170412170255060","JCYJ20160324163759208","JCYJ20170412171856582","JCYJ20170816161836562","JCYJ20170817111912585"],"award-info":[{"award-number":["JCYJ20160428182247170","JCYJ20170412170255060","JCYJ20160324163759208","JCYJ20170412171856582","JCYJ20170816161836562","JCYJ20170817111912585"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A phase-sensitive fluidic biosensor based on a spectral-domain low-coherence interferometer is presented in this paper. With a fiber optic probe employing the common-path interferometric configuration, subnanometric changes in thickness of the molecular layers can be detected through phase analysis of the acquired interference signal from the sensor surface. Advantages of this biosensor include its picometer-scale thickness sensitivity, 13.9-ms time response, and tolerance to the fluctuation in concentration of the target solution. The capabilities of this biosensor in monitoring specific molecular binding and recognizing specific molecular was successfully demonstrated by using the reactions between the molecules of protein A and IgG. The calculated minimum detectable concentration of IgG is 0.11 \u00b5g\/mL.<\/jats:p>","DOI":"10.3390\/s18113757","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T10:43:45Z","timestamp":1541414625000},"page":"3757","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Fluidic Biosensor Based on a Phase-Sensitive Low-Coherence Spectral-Domain Interferometer"],"prefix":"10.3390","volume":"18","author":[{"given":"Cuixia","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Physics, Tsinghua University, Beijing 100084, China"},{"name":"Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0551-6252","authenticated-orcid":false,"given":"Xiaojie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China"}]},{"given":"Zhiyuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Orbbec Co., Ltd., 12\/F, No. 63 Xuefu Road, Nanshan District, Shenzhen 518055, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-2398","authenticated-orcid":false,"given":"Jian-Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China"},{"name":"Academy of Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China"}]},{"given":"Suyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Yonghong","family":"He","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"}]},{"given":"Tian","family":"Guan","sequence":"additional","affiliation":[{"name":"Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"}]},{"given":"Fangyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00216-006-0930-3","article-title":"A microfluidic system for evaluation of antioxidant capacity based on a peroxyoxalate chemiluminescence assay","volume":"387","author":"Amatatongchai","year":"2007","journal-title":"Anal. 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