{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:18:03Z","timestamp":1774113483809,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61875102, 61675113, 61527808"],"award-info":[{"award-number":["61875102, 61675113, 61527808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Research Program of Shenzhen City","award":["JCYJ20160428182247170, JCYJ20170412170255060, JCYJ20160324163759208, JCYJ20170412171856582, JCYJ20170816161836562, JCYJ20170817111912585"],"award-info":[{"award-number":["JCYJ20160428182247170, JCYJ20170412170255060, JCYJ20160324163759208, JCYJ20170412171856582, JCYJ20170816161836562, JCYJ20170817111912585"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>We propose a self-referential fast detection scheme for a frequency domain weak measurement system for the detection of enantiomeric impurities in chiral molecules. In a transmissive weak measurement system, the optical rotation (OR) is used to modify the pre-selected polarization state and the post-selection polarization state. We obtained the sum and difference of the optical rotations produced by the sample and the standard by rotating the quarter wave plate in the system. Then, we estimate the ratio of chiral molecules to enantiomeric impurities using the ratio of the central wavelength shifts caused by the addition and subtraction states described above. In this paper, our system has an optical resolution of 1.88 \u00d7 10\u22125\u00b0. At the same time, we completed the detection of the ratio of the two substances in the mixture of L-proline and D-proline in different proportions, which proved that our system can quickly detect the content of enantiomeric impurities in chiral molecules.<\/jats:p>","DOI":"10.3390\/s18113788","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T03:45:22Z","timestamp":1541562322000},"page":"3788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System"],"prefix":"10.3390","volume":"18","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"}]},{"given":"Lixuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"Department of Physics, Tsinghua University, Beijing 100084, China"}]},{"given":"Tian","family":"Guan","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Suyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Xuesi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Optics &amp; Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China"}]},{"given":"Cuixia","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"Department of Physics, Tsinghua University, Beijing 100084, China"}]},{"given":"Yuxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Xiangnan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Zhangyan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"Department of Physics, Tsinghua University, Beijing 100084, China"}]},{"given":"Yonghong","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"Department of Physics, Tsinghua University, Beijing 100084, China"}]},{"given":"Luyuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China"},{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}]},{"given":"Zonghan","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of biomedical engineering, University of Glasgow, 89 Dumbarton Rd, Glasgow G12 8QQ, UK"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/chir.20372","article-title":"Chirality as a tool in nucleic acid recognition: Principles and relevance in biotechnology and in medicinal chemistry","volume":"19","author":"Corradini","year":"2007","journal-title":"Chirality"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199600525-00003","article-title":"Drug chirality and its clinical significance","volume":"52","author":"Hutt","year":"1996","journal-title":"Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1002\/chir.10270","article-title":"Determination of absolute configuration using ab initio calculation of optical rotation","volume":"15","author":"Stephens","year":"2003","journal-title":"Chirality"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1002\/chir.20109","article-title":"Determination of absolute configurations of chiral molecules using ab initio time-dependent density functional theory calculations of optical rotation: How reliable are absolute configurations obtained for molecules with small rotations?","volume":"17","author":"Stephens","year":"2005","journal-title":"Chirality"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"173002","DOI":"10.1103\/PhysRevLett.97.173002","article-title":"Chiral molecules split light: Reflection and refraction in a chiral liquid","volume":"97","author":"Ghosh","year":"2006","journal-title":"Phys. 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